Zobrazeno 1 - 10
of 19
pro vyhledávání: '"S. C. Gad"'
Publikováno v:
Humanexperimental toxicology. 36(7)
Pyridorin®, a naturally occurring metabolite of vitamin B6 that inhibits and scavenges reactive oxygen species, is being developed as a potential therapeutic for acute kidney injury. An investigational new drug application (IND) was opened for Pyrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43e5f575f51ab10dd18e691c193503c
https://pubmed.ncbi.nlm.nih.gov/27507076
https://pubmed.ncbi.nlm.nih.gov/27507076
Publikováno v:
International Journal of Toxicology. 22:415-422
The most commonly used nonrodent species in regulatory toxicity and safety assessment studies has been and remains the dog, with the beagle being the standard breed employed. Although a standard functional observational battery (FOB) or neurobehavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af5edcecbb0b84e5d4c499d86bdb74d
https://doi.org/10.1177/109158180302200602
https://doi.org/10.1177/109158180302200602
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 35(1)
The brief of the Organotypic Models Working Group was to review data submitted to the Interagency Regulatory Alternatives Group on the use of isolated eyes and components of the eye used to predict eye irritation potential. Data submissions were rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2039d4291ca732397b992848ce00be0e
https://pubmed.ncbi.nlm.nih.gov/9100813
https://pubmed.ncbi.nlm.nih.gov/9100813
Autor:
Myles Clancy, S. C. Gad, M.H. Silverman, M.A. Wolf, E. Choy, Geoffrey I. Shapiro, S. Mani, L.C. Cuasay, J.M. Cleary, B.J. Dezube
Publikováno v:
European Journal of Cancer Supplements. 8:181
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::281c6d802f69b010b895296ea20a966e
https://doi.org/10.1016/s1359-6349(10)72282-5
https://doi.org/10.1016/s1359-6349(10)72282-5
Autor:
Myles Clancy, James M. Cleary, E. Choy, S. C. Gad, Geoffrey I. Shapiro, M. H. Parkman, Michael H. Silverman, M.A. Wolf, Bruce J. Dezube, S. Mani
Publikováno v:
Journal of Clinical Oncology. 28:e13119-e13119
e13119 Background: ALB 109564(a) [ALB] is a vinca alkaloid, which functions as a tubulin inhibitor, interfering with microtubule polymerization resulting in metaphase arrest. In preclinical studies...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee55afffbab5c9e863e8bd7314c01a7b
https://doi.org/10.1200/jco.2010.28.15_suppl.e13119
https://doi.org/10.1200/jco.2010.28.15_suppl.e13119
Autor:
S C, Gad
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 15(1)
Significant progress has been made in replacing animals in toxicology/safety assessment with in vitro systems, in reducing the number of animals used, and in refining how they are used. Review of annual reports of the numbers of animals used in testi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1c0c8b3e6a3ecc0b7aef3acc1e9638c
https://pubmed.ncbi.nlm.nih.gov/2197147
https://pubmed.ncbi.nlm.nih.gov/2197147
Publikováno v:
Toxicological Sciences. 8:583-594
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30b4a2886ea574645e1a0c4365a5a2e8
https://doi.org/10.1093/toxsci/8.4.583
https://doi.org/10.1093/toxsci/8.4.583
Publikováno v:
Drug and Chemical Toxicology. 8:451-468
Thirteen cationic ionophores (12-Crown-4, 15-Crown-5, 18-Crown-6, Dibenzo 18-Crown-6, Dicyclohexano 18-Crown-6, 24-Crown-8, Dicyclohexano 24-Crown-8, Lasalocid, Hexacyclen trisulfate, Chiral binapthol, Valinomycin, Monensin, and A-23187) were evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3690e91ce9e1272b3b185d6bf1503ac
https://doi.org/10.3109/01480548509041069
https://doi.org/10.3109/01480548509041069
Publikováno v:
Drug and chemical toxicology. 1(4)
18-CROWN-6 was assessed for neurologic effects in rats, mice, and rabbits by intravenous (IV) and intraperitoneal (IP) routes of administration. Male rats and mice exhibited no effects with IV doses to 20 mg/kg. Given IP doses of 20 to 160 mg/kg/day,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc008575788ee0dbd0ba9bccf91716f
https://pubmed.ncbi.nlm.nih.gov/755674
https://pubmed.ncbi.nlm.nih.gov/755674
Autor:
S C, Gad
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 11(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68e28c027c38f40d89500d29ed80f213
https://pubmed.ncbi.nlm.nih.gov/3147921
https://pubmed.ncbi.nlm.nih.gov/3147921