Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE ε4 allele, in relation to cognitive function and cerebral glucose metabolism

Autor: T. Darreh-Shori, S. Brimijoin, A. Kadir, O. Almkvist, A. Nordberg

Publikováno v: Neurobiology of Disease, Vol 24, Iss 2, Pp 326-333 (2006)

Butyrylcholinesterase (BuChE) is increased in the cerebral cortex of Alzheimer's disease (AD) patients, particularly those carrying ε4 allele of the apolipoprotein E gene (ApoE) and certain BuChE variants that predict increased AD risk and poor resp

Externí odkaz: https://doaj.org/article/f4639436b3b64dc28477255d2a5155ea

List of Contributors

Autor: C.J. Alves, P. Anglard, K. Anier, R.A. Armstrong, R.K. Bachtell, K. Bakshi, P. Barbanti, P. Barrio, A. Batalla, J.B. Becker, A. Bekker, C. Benkelfat, J. Bergman, P. Bhattacharya, Veronica Bisagno, S. Brimijoin, Z.J. Brown, D. Buffalari, K.-M. Bühler, L. Caffino, G. Cafforio, R. Camarini, V.M. Carvalho, L.C.S. Cepko, C.-C. Chen, X.-P. Chu, L.H. Corbit, E.J. Crofton, C.L. Crunelle, P.J. Cunha, T. Cunha-Oliveira, P.J. Currie, M. D’Ascenzo, L.H.J. Dieckmann, L. von Diemen, E.C. Dumont, A.L. Eagle, B.A. Eipper, J.E. Eipper-Mains, M. Engeln, S. Erb, A. Farré, M. Farré, A.S. Felts, L. Fofi, J.D. Foster, H.C. Fox, M. Frankfurt, M. Freissmuth, R.A. Fuchs, F. Fumagalli, P.A. Gajewski, E. Galaj, J.C.F. Galduróz, E.E. Garling, T.A. Gentile, G. Giannotti, J.-A. Girault, J.D. Glass, P.D. Goncalves, A. González-Duarte, V. Gonzalez-Nunez, R.W. Gould, C. Grassi, T.A. Green, T. Green-Sadan, H.H. Gu, Xiaowei Guan, B. Halbout, D.D. Han, L.K. Henry, J.L. Pérez de Heredia, J.A. Higginbotham, T. Hofmaier, M. Holy, K.-S. Hsu, C.-C. Huang, J. James, A.W. Jones, C.K. Jones, A. Kalda, D.N. Kearns, H.N. Kerver, F. Kessler, S.J. Kohut, K. Krnjević, P. Kucab, O. Kudlacek, D.A. Kupferschmidt, E.V. Kuzhikandathil, M.R. Lee, L. Leggio, J.R. Lever, S.Z. Lever, M. Leyton, J.-X. Li, D.R. Lima, M.K. Lobo, J.A. López-Moreno, H. López-Pelayo, D.A. Lovejoy, A. Luf, M.D.M.V. Lugon, C.E. Lyons, A. Magalhães, P.V.S. Magalhães, M. Mainardi, R.E. Mains, J.R. Mantsch, T. Marcourakis, R. Marhe, F. Matthys, S. El Mestikawy, V. Milivojevic, D.K. Miller, M.O. Min, S. Minnes, M.R. Mitchell, P.R. Monteiro, V. Murthy, J.W. Muschamp, C. Nagy, E.M. Nakamura-Palacios, J.C.M. Narvaez, C.P. Normandeau, F. Ornell, C.A. Orsini, S.B. Ostlund, J. Otkins, V.B. Patel, F.S. Pelição, S.P. Pereira, M.D. Peres, M.N. Potenza, V.R. Preedy, R.A. Prosser, B.B. Quednow, R. Rajendram, A.C. Ramos, R. Ranaldi, C. Rangel-Barajas, G.V. Rebec, A.J. Robison, R.E. Rodríguez, M.C.H. Rohn, I. Roth-Deri, S.G. Scala, C. Scavone, A. Schellekens, J. Scherer, R. Schmid, R.D. Scurlock, B. Setlow, S.J. Simmons, L.T. Singer, R. Sinha, H.H. Sitte, K. Smart, T. Stockner, T. Summavielle, K.K. Szumlinski, G. Tanda, M. Torrens, B.J. Tunstall, F.J. Urbano, R.A. Vaughan, M. Verhaeghe, M. Vonmoos, J.J. Wagner, Y. Wang, Z.-X. Xi, Y. Xu, G. Yadid, J.-H. Ye, S. Yoon, L.J. Zallar, Chang-Guo Zhan, H.-Y. Zhang, Y. Zhang, Fang Zheng, W. Zuo, J. Zwiller

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d02bdbc4a23e14ca18c8f4820ead3f26
https://doi.org/10.1016/b978-0-12-803750-8.00078-6

Novel Transcription Start Site for Murine AChE

Autor: S. Brimijoin, E. Atanasova

Publikováno v: Structure and Function of Cholinesterases and Related Proteins ISBN: 9781489915429

Evidence is accumulating to suggest more than one functional promoter in the gene for murine acetylcholinesterase (Ache). Previously, we detected moderately strong activity (12.5 times background) when a DNA sequence upstream of the established promo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c444704083fedc50a2350191a152e259
https://doi.org/10.1007/978-1-4899-1540-5_17

Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease

Autor: Y P, Pang, P, Quiram, T, Jelacic, F, Hong, S, Brimijoin

Publikováno v: The Journal of biological chemistry. 271(39)

We report highly potent, selective, and low cost bifunctional acetylcholinesterase (AChE) inhibitors developed by our two-step prototype optimization strategy utilizing computer modeling of ligand docking with target proteins: 1) identify low affinit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08b9cbc626451f85f6df4dd95cf4dc1f
https://pubmed.ncbi.nlm.nih.gov/8798583

Emulsifier for intravenous cyclosporin inhibits neurite outgrowth, causes deficits in rapid axonal transport and leads to structural abnormalities in differentiating N1E.115 neuroblastoma

Autor: D J, Brat, A J, Windebank, S, Brimijoin

Publikováno v: The Journal of pharmacology and experimental therapeutics. 261(2)

The emulsifier for cyclosporin in clinical i.v. formulations, Cremophor EL, has recently come into question as a possible source of neurotoxic side effects in immunosuppressant therapy. To address this issue we tested Cremophor EL and cyclosporin on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::456225598fe5d4b2e11e022463fdb650
https://pubmed.ncbi.nlm.nih.gov/1578386