Výsledky vyhledávání - "S. Brian Wilson"

Isolation and Functional Use of Human NKT Cells

Autor: Mark A. Exley, S. Brian Wilson, Steven P. Balk

Publikováno v: Current protocols in immunologyLiterature Cited. 119

This unit details methods for the isolation, in vitro expansion, and functional characterization of human iNKT cells. The term 'iNKT' derives from the fact that a large fraction of murine and some human NK marker+ T cells ('NKT') recognize the MHC cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b60175246813e4f627be4eda36843b3
https://pubmed.ncbi.nlm.nih.gov/29091262

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Use of Nonobese Diabetic Mice to Understand Human Type 1 Diabetes

Autor: Terri C. Thayer, S. Brian Wilson, Clayton E. Mathews

Publikováno v: Endocrinology and Metabolism Clinics of North America. 39:541-561

In 1922, Leonard Thompson received the first injections of insulin prepared from the pancreas of canine test subjects. From pancreatectomized dogs to the more recent development of animal models that spontaneously develop autoimmune syndromes, animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ca143ec77b14f19f90430c8e92527a1
https://doi.org/10.1016/j.ecl.2010.05.001

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A CD1d-Dependent Antagonist Inhibits the Activation of Invariant NKT Cells and Prevents Development of Allergen-Induced Airway Hyperreactivity

Autor: S. Brian Wilson, Xiangming Li, Steven A. Porcelli, Karl O.A. Yu, Mitchell Kronenberg, Vincent Lombardi, Takayuki Shiratsuchi, Jerome Kerzerho, Abinav K. Singh, Moriya Tsuji, Omid Akbari, Philippe Stock, Wen Yang, Barbara A. Sullivan, Nathan E. Hnatiuk, Amy R. Howell

Publikováno v: The Journal of Immunology. 184:2107-2115

The prevalence of asthma continues to increase in westernized countries, and optimal treatment remains a significant therapeutic challenge. Recently, CD1d-restricted invariant NKT (iNKT) cells were found to play a critical role in the induction of ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20736234467005ac6c1136f83c4f6e55
https://doi.org/10.4049/jimmunol.0901208

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Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR α-chain CDR3 loop

Autor: Mark A. Exley, Jonathan E. Boyson, Giulia Casorati, Angela Shaulov, Steven P. Balk, Jenny E. Gumperz, Runhua Hou, Omid Akbari, H. Orhan Akman, Paolo Dellabona, Edward A. Greenfield, S. Brian Wilson, Elena Tonti

Publikováno v: European Journal of Immunology. 38:1756-1766

A significant fraction of CD1d-restricted T cells express an invariant T cell receptor (TCR) alpha-chain. These highly conserved invariant NKT (iNKT) populations are important regulators of a wide spectrum of immune responses. The ability to directly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4c179f49db6a344d3a3bade2bd8974
https://doi.org/10.1002/eji.200737389

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Activation of Plasmacytoid Dendritic Cells with TLR9 Agonists Initiates Invariant NKT Cell-Mediated Cross-Talk with Myeloid Dendritic Cells

Autor: Lena Al-Harthi, Candice B Mulder, Carlos J. Montoya, María Teresa Rugeles, Hyun-Bae Jie, S. Brian Wilson, Arthur M. Krieg, Alan L. Landay, Pablo J. Patiño

Publikováno v: The Journal of Immunology. 177:1028-1039

CD1d-restricted invariant NK T (iNKT) cells and dendritic cells (DCs) have been shown to play crucial roles in various types of immune responses, including TLR9-dependent antiviral responses initiated by plasmacytoid DCs (pDCs). However, the mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1d7e00fa83d783fba606e457a937d0
https://doi.org/10.4049/jimmunol.177.2.1028

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CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity

Autor: Rik J. Scheper, Richard S. Blumberg, Steven P. Balk, Masaru Taniguchi, Silke Gillessen, S. Brian Wilson, Mark A. Exley, Edward E. S. Nieuwenhuis, Glenn Dranoff, Jack L. Strominger

Publikováno v: Experimental Dermatology, 14(4), 250-258. Wiley-Blackwell Publishing Ltd
Experimental Dermatology, 14(4), 250-258. Wiley-Blackwell
Nieuwenhuis, E E, Gillessen, S, Scheper, R J, Exley, M A, Taniguchi, M, Balk, S P, Strominger, J L, Dranoff, G, Blumberg, R S & Wilson, S B 2005, ' CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity ', Experimental Dermatology, vol. 14, no. 4, pp. 250-258 . https://doi.org/10.1111/j.0906-6705.2005.00289.x

CD1d-restricted T-cells are activated by glycolipids presented by the major histocompatibility complex class-Ib molecule CD1d, found on the surface of antigen-presenting cells (APC). This interaction between APC, most notably dendritic cells (DC), an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c55120318cb6489630cfb61c1e60396
https://doi.org/10.1111/j.0906-6705.2005.00289.x

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Natural Killer T Cells Infiltrate Neuroblastomas Expressing the Chemokine CCL2

Autor: Yujun Yang, Leonid S. Metelitsa, Hong-Wei Wu, Susan Groshen, Robert C. Seeger, Shahab Asgharzadeh, Zamir Warsi, Hong Wang, S. Brian Wilson

Publikováno v: The Journal of Experimental Medicine

CD1d-restricted Vα24-Jα18–invariant natural killer T cells (iNKTs) are potentially important in tumor immunity. However, little is known about their localization to tumors. We analyzed 98 untreated primary neuroblastomas from patients with metast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37113bc89c71d0fd32305fd787dc1500
https://doi.org/10.1084/jem.20031462

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Disseminated Varicella Infection Due to the Vaccine Strain of Varicella‐Zoster Virus, in a Patient with a Novel Deficiency in Natural Killer T Cells

Autor: Gary R. Fleisher, Angela Shaulov, Mark A. Exley, Raif S. Geha, Jordan S. Orange, Adriana Weinberg, Patricia L. Hibberd, P. LaRussa, Sharon Steinberg, Ofer Levy, Francisco A. Bonilla, S. Brian Wilson

Publikováno v: The Journal of Infectious Diseases. 188:948-953

An 11-year-old girl presented with a papulovesicular rash and severe respiratory distress 5 weeks after receiving varicella vaccine. Restriction fragment length-polymorphism analysis of virus isolated from an endotracheal-tube aspirate and from bronc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e9abb915727010ed50694a9e2a431b
https://doi.org/10.1086/378503

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Regulation of dendritic cell subsets by NKT cells

Autor: S. Brian Wilson, Jack L. Strominger, Michael C. Byrne

Publikováno v: Comptes Rendus Biologies. 326:1045-1048

NKT cells expressing both invariant TCRs and NK cell receptors are an important regulatory cell subset active during initiation of innate immune responses. They are involved in a wide variety of immune responses, but the molecular details of their re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2adbe0e1ffd485a5967efed4155f641
https://doi.org/10.1016/j.crvi.2003.09.023

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