Zobrazeno 1 - 10
of 27
pro vyhledávání: '"S. Bosan"'
Publikováno v:
Bulletin of Mathematical Biology. 56:225-247
We have developed a new model describing the relationship between plasma and red cell tracers flowing through the lung. The model is the result of an analysis of the transport of radiolabeled plasma albumin between two flowing phases and shows that d
Autor:
S. Bosan, T.R. Harris
Publikováno v:
Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ.
Publikováno v:
Bulletin of Mathematical Biology. 57:931-933
Publikováno v:
Carcinogenesis. 7:413-418
Administration of the hepatotoxin and carcinogen, inorganic hydrazine, to rodents results in the formation of 7-methylguanine and O6-methylguanine in liver DNA; co-administration of [methyl-14C]methionine or [14C]formate with the hydrazine labels the
Publikováno v:
Carcinogenesis. 8:439-444
Hydrazine is carcinogenic to the mouse and rat, but three earlier studies have reported no carcinogenicity of hydrazine in the hamster. Administration of hydrazine to mice, rats and hamsters results in rapid methylation of liver DNA guanine for which
Autor:
William S. Bosan, Ronald C. Shank
Earlier studies demonstrated that hydrazine administration to rodents results in the methylation of liver DNA guanine and that S-adenosylmethionine was the apparent methyl donor in this response. The present study characterized the hamster as an anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10f94185637c7a7acccfc697cec277db
https://doi.org/10.21236/ada132944
https://doi.org/10.21236/ada132944
Autor:
William S. Bosan, Ronald C. Shank
Publikováno v:
Toxicology and applied pharmacology. 70(2)
Formation of 7-methylguanine and O6-methylguanine in liver DNA was measured 24 hr after administration of various single oral doses of 15 to 120 mg hydrazine/kg body wt to Syrian golden hamsters, and at various times up to 96 hr after a single oral d
Oral administration of the inorganic hepatotoxin, hydrazine, to male Fischer 344 or Sprague Dawley rats results in the endogenous methylation of liver DNA at the 7- and O6-positions of guanine. At doses below the LD50 (45, 60 or 75 mg hydrazine/kg bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3b968640aaa6887a711b2fd206b664
https://doi.org/10.21236/ada119124
https://doi.org/10.21236/ada119124
Publikováno v:
Carcinogenesis. 7(3)
Hydrazine induces methylation of target-organ DNA guanine; the methylation mechanism was proposed to involve reaction of hydrazine with endogenous formaldehyde. One possible condensation product of hydrazine and formaldehyde is tetraformyltrisazine (
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