Zobrazeno 1 - 10
of 365
pro vyhledávání: '"S. Bonifacino"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract ARL5 is a member of the ARF family of small GTPases that is recruited to the trans-Golgi network (TGN) by another ARF-family member, ARFRP1, in complex with the transmembrane protein SYS1. ARL5 recruits its effector, the multisubunit tetheri
Externí odkaz:
https://doaj.org/article/734790d8b84f43e6a504954e8de0af63
Autor:
Salimata Diarra, Saikat Ghosh, Lassana Cissé, Thomas Coulibaly, Abdoulaye Yalcouyé, George Harmison, Salimata Diallo, Seybou H. Diallo, Oumar Coulibaly, Alice Schindler, Cheick A.K. Cissé, Alassane B. Maiga, Salia Bamba, Oumar Samassekou, Mustafa K. Khokha, Emily K. Mis, Saquib A. Lakhani, Frank X. Donovan, Steve Jacobson, Craig Blackstone, Cheick O. Guinto, Guida Landouré, Juan S. Bonifacino, Kenneth H. Fischbeck, Christopher Grunseich
Publikováno v:
Neurobiology of Disease, Vol 198, Iss , Pp 106537- (2024)
Hereditary spastic paraplegia (HSP) comprises a large group of neurogenetic disorders characterized by progressive lower extremity spasticity. Neurological evaluation and genetic testing were completed in a Malian family with early-onset HSP. Three c
Externí odkaz:
https://doaj.org/article/ae7527cfc144494db6ca02e0b1ec3625
Autor:
Xin Chen, Thomas Dong, Yuhui Hu, Raffaella De Pace, Rafael Mattera, Kathrin Eberhardt, Marvin Ziegler, Terry Pirovolakis, Mustafa Sahin, Juan S. Bonifacino, Darius Ebrahimi-Fakhari, Steven J. Gray
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Spastic paraplegia 50 (SPG50) is an ultrarare childhood-onset neurological disorder caused by biallelic loss-of-function variants in the AP4M1 gene. SPG50 is characterized by progressive spastic paraplegia, global developmental delay, and subsequent
Externí odkaz:
https://doaj.org/article/2bba6f1c88c84947824d953a3f8dcd7e
Autor:
Tal Keren-Kaplan, Amra Sarić, Saikat Ghosh, Chad D. Williamson, Rui Jia, Yan Li, Juan S. Bonifacino
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Organellar transport is carefully regulated, and endolysosome localized ARL8 is important for kinesin recruitment and anterograde movement. Here, the authors show that RUFY3 and RUFY4 promote retrograde transport of endolysosomes by mediating interac
Externí odkaz:
https://doaj.org/article/de5673f787304fe384e3b17410c143de
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes
Autor:
Ariane Schleinitz, Lara-Alina Pöttgen, Tal Keren-Kaplan, Jing Pu, Paul Saftig, Juan S. Bonifacino, Albert Haas, Andreas Jeschke
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111969- (2023)
Summary: The transfer of endocytosed cargoes to lysosomes (LYSs) requires HOPS, a multiprotein complex that tethers late endosomes (LEs) to LYSs before fusion. Many proteins interact with HOPS on LEs/LYSs. However, it is not clear whether these HOPS
Externí odkaz:
https://doaj.org/article/e4be13848ad041cbb5e8397c89a65ade
Autor:
Elodie Mailler, Carlos M. Guardia, Xiaofei Bai, Michal Jarnik, Chad D. Williamson, Yan Li, Nunziata Maio, Andy Golden, Juan S. Bonifacino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
ATG9A is transmembrane autophagic machinery protein that delivers phospholipids to expanding autophagosomes. Mailler et al. show that ATG9A is required to mobilize lipids from lipid droplets for autophagosome expansion as well as mitochondrial fatty
Externí odkaz:
https://doaj.org/article/bc3b482686c54ef6a34fb727e681922d
Autor:
Anika V. Prabhu, Insung Kang, Raffaella De Pace, Christopher A. Wassif, Hideji Fujiwara, Pamela Kell, Xuntian Jiang, Daniel S. Ory, Juan S. Bonifacino, Michael E. Ward, Forbes D. Porter
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Niemann-Pick disease, type C (NPC) is a childhood-onset, lethal, neurodegenerative disorder caused by autosomal recessive mutations in the genes NPC1 or NPC2 and characterized by impaired cholesterol homeostasis, a lipid essential
Externí odkaz:
https://doaj.org/article/fbf727df91264aa1910bff5cd9a48708
Autor:
Amra Saric, Spencer A. Freeman, Chad D. Williamson, Michal Jarnik, Carlos M. Guardia, Michael S. Fernandopulle, David C. Gershlick, Juan S. Bonifacino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Endoplasmic reticulum (ER)-interorganelle membrane contact sites have emerged as key regulators of organelle dynamics. Here, the authors report that the ER-resident protein SNX19 mediates ER-endolysosome membrane contacts to maintain the perinuclear
Externí odkaz:
https://doaj.org/article/31d67507b07347d8ba1e4e2dbd2246c1
Autor:
Aysegul Dilsizoglu Senol, Maura Samarani, Sylvie Syan, Carlos M Guardia, Takashi Nonaka, Nalan Liv, Patricia Latour-Lambert, Masato Hasegawa, Judith Klumperman, Juan S Bonifacino, Chiara Zurzolo
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001287 (2021)
The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a "prion-like" manner and can be transferred inside lysosomes to recipi
Externí odkaz:
https://doaj.org/article/8d3afd767fd24d5ca05e43b7ded91e8a
Autor:
Elodie Mailler, Abdul A. Waheed, Sang-Yoon Park, David C. Gershlick, Eric O. Freed, Juan S. Bonifacino
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-20 (2019)
Abstract Background Nef is a multifunctional accessory protein encoded by HIV-1, HIV-2 and SIV that plays critical roles in viral pathogenesis, contributing to viral replication, assembly, budding, infectivity and immune evasion, through engagement o
Externí odkaz:
https://doaj.org/article/15f486e3b7c54ad2811b555746324431