Zobrazeno 1 - 10
of 645
pro vyhledávání: '"S. Besra"'
Autor:
Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mycobacterial glycolipids are important cell envelope structures that drive host-pathogen interactions. Arguably, the most important are lipoarabinomannan (LAM) and its precursor, lipomannan (LM), which are trafficked from the bacterium to t
Externí odkaz:
https://doaj.org/article/6d93ff76e3f4412dafd8078e53d92041
Autor:
Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily P. S. Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M. Denham, Giulia Masi, Phyllis Tea Qing Yun, Colin Moore, Selsabil Dhaouadi, Gurdyal S. Besra, Natacha Veerapen, Patricia T. Illing, Julian P. Vivian, Jeremy M. Raynes, Jérôme Le Nours, Anthony W. Purcell, Samit Kundu, Jonathan D. Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Duncan Howie, Joseph Dukes
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection.
Externí odkaz:
https://doaj.org/article/8f539e9eaf5e40e19fbc3e2c06f07574
Autor:
Manisha Singh, Sarah M. Batt, Christian S. C. Canales, Fernando R. Pavan, Sethu Arun Kumar, Handattu S. Akshatha, Meduri Bhagyalalitha, Karthik G. Pujar, Durgesh Bidye, Gurubasavaraj V. Pujar, Gurdyal S. Besra
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Decaprenylphosphoryl-β-D-ribose-oxidase (DprE1), a subunit of the essential decaprenylphosphoribose-2′-epimerase, plays a crucial role in the synthesis of cell wall arabinan components in mycobacteria, including the pathogen responsible for tuberc
Externí odkaz:
https://doaj.org/article/4124a2b93e134bebba90041ad4810e15
Publikováno v:
The Cell Surface, Vol 11, Iss , Pp 100122- (2024)
Externí odkaz:
https://doaj.org/article/6f06df23223b4f97a50cfd5ef2d34014
Autor:
Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/788b328ee3d0461e94235c15cafbf14f
DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid
Autor:
Katherine A. Abrahams, Sarah M. Batt, Sudagar S. Gurcha, Natacha Veerapen, Ghader Bashiri, Gurdyal S. Besra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Mycobacterium tuberculosis is one of the global leading causes of death due to a single infectious agent. Pretomanid and delamanid are new antitubercular agents that have progressed through the drug discovery pipeline. These compounds are bi
Externí odkaz:
https://doaj.org/article/40bdd0a34d744b8786bc6a3db7dc1740
Autor:
Sophie Papa, Luke Williams, Joseph Dukes, Jamie Rossjohn, Jonathan D Silk, Suzanne Cole, Emily Lam, Samit Kundu, Katarzyna Ward, Duncan Howie, Terri V Cornforth, Nathifa Moyo, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Eleanor M Denham, Gurdyal S Besra, Patricia Illing, Bruce MacLachlan, Julian Vivian, Jeremy Raynes, Jerome Le Nours, Anthony Purcell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/d7d61dd8f23b40c19240771e3414c4c9
Autor:
Suzanne E. Engelen, Francesca A. Ververs, Angela Markovska, B. Christoffer Lagerholm, Jordan M. Kraaijenhof, Laura I.E. Yousif, Yasemin-Xiomara Zurke, Can M.C. Gulersonmez, Sander Kooijman, Michael Goddard, Robert J. van Eijkeren, Peter J. Jervis, Gurdyal S. Besra, Saskia Haitjema, Folkert W. Asselbergs, Eric Kalkhoven, Hidde L. Ploegh, Marianne Boes, Vincenzo Cerundolo, G.K. Hovingh, Mariolina Salio, Edwin C.A. Stigter, Patrick C.N. Rensen, Claudia Monaco, Henk S. Schipper
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Invariant natural killer T (iNKT) cells act at the interface between lipid metabolism and immunity because of their restriction to lipid antigens presented on CD1d by antigen-presenting cells (APCs). How foreign lipid antigens are delivered to APCs r
Externí odkaz:
https://doaj.org/article/8fb8c477cbe54ae48780c91ea0abd92d
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Mycobacterium tuberculosis is a deadly pathogen, currently the leading cause of death worldwide from a single infectious agent through tuberculosis infections. If the End TB 2030 strategy is to be achieved, additional drugs need to be identified and
Externí odkaz:
https://doaj.org/article/d80a54427b044338ab7f002518711d80
Autor:
Padam Singh, Srishti Rawat, Ashish Kumar Agrahari, Manisha Singh, Saurabh Chugh, Sudagar Gurcha, Albel Singh, Katherine Abrahams, Gurdyal S. Besra, Shailendra Asthana, Diwan S. Rawat, Ramandeep Singh
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The complexity and duration of tuberculosis (TB) treatment contributes to the emergence of drug resistant tuberculosis (DR-TB) and drug-associated side effects. Alternate chemotherapeutic agents are needed to shorten the time and improve eff
Externí odkaz:
https://doaj.org/article/4c455146b10e4a6782f523375f037d3a