Arsenal of Nanobodies for Broad-Spectrum Countermeasures against Current and Future SARS-CoV-2 Variants of Concerns

Autor: M. A. Rossotti, H. van Faassen, A. Tran, J. Sheff, J. K. Sandhu, D. Duque, M. Hewitt, S. Wen, R. Bavananthasivam, S. Beitari, K. Matte, G. Laroche, P. M. Giguère, C. Gervais, M. Stuible, J. Guimond, S. Perret, G. Hussack, M.-A. Langlois, Y. Durocher, J. Tanha

Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2. Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern (VoCs) and feasibility to engineer modular, multimeric designs, make these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f85116ef8e5a30a2f01a5348f0604352
https://doi.org/10.1101/2021.12.20.473401

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Assessment of Single-Cycle M-Protein Mutated Vesicular Stomatitis Virus as a Safe and Immunogenic Mucosal Vaccine Platform for SARS-CoV-2 Immunogen Delivery.

Autor: Zhang E; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.; Shanghai Municipal Veterinary Key Laboratory, Shanghai, 200240, China., Ke Y; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road, Minhang District, Shanghai, 200240, China., Ran W; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.; Shanghai Municipal Veterinary Key Laboratory, Shanghai, 200240, China., Zhang Y; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.; Shanghai Municipal Veterinary Key Laboratory, Shanghai, 200240, China., Li R; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.; Shanghai Municipal Veterinary Key Laboratory, Shanghai, 200240, China., Fang X; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China., Wang L; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road, Minhang District, Shanghai, 200240, China., Zhang B; Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road, Minhang District, Shanghai, 200240, China., Sun T; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.; Shanghai Municipal Veterinary Key Laboratory, Shanghai, 200240, China.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Dec; Vol. 11 (47), pp. e2404197. Date of Electronic Publication: 2024 Nov 11.

Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2.

Autor: Lázaro‐Gorines, Rodrigo^1,2,3 (AUTHOR), Pérez, Patricia^4,5 (AUTHOR), Heras‐Murillo, Ignacio⁶ (AUTHOR), Adán‐Barrientos, Irene⁶ (AUTHOR), Albericio, Guillermo⁴ (AUTHOR), Astorgano, David⁴ (AUTHOR), Flores, Sara⁴ (AUTHOR), Luczkowiak, Joanna⁷ (AUTHOR), Labiod, Nuria⁷ (AUTHOR), Harwood, Seandean L.⁸ (AUTHOR), Segura‐Tudela, Alejandro^1,2,3 (AUTHOR), Rubio‐Pérez, Laura^1,2,3,9 (AUTHOR), Nugraha, Yudhi¹⁰ (AUTHOR), Shang, Xiaoran^11,12 (AUTHOR), Li, Yuxing^11,12,13 (AUTHOR), Alfonso, Carlos¹⁴ (AUTHOR), Adipietro, Kaylin A.^13,15 (AUTHOR), Abeyawardhane, Dinendra L.^11,13,15 (AUTHOR), Navarro, Rocío¹⁶ (AUTHOR), Compte, Marta¹⁶ (AUTHOR)

Publikováno v: Advanced Science. Dec2023, Vol. 10 Issue 34, p1-17. 17p.

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