CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

Autor: Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguière, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker S. Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, Ann M. Graybiel

Publikováno v: Neurobiology of Disease, Vol 158, Iss , Pp 105473- (2021)

CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington's disease and l

Externí odkaz: https://doaj.org/article/dcb665d27eb248cbbbad7e35d7e418a7

Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats

Autor: S. Stevens Negus, S. Barak Caine, E. Andrew Townsend, Morgane Thomsen, Matthew L. Banks

Publikováno v: Neuropsychopharmacology. 44:2022-2029

Clinical evidence suggest that men are more sensitive than women to the abuse-related effects of mu-opioid agonists. In contrast, preclinical studies suggest the opposite sex difference. The aim of the present study was to clarify this discrepancy us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8ad36c9458ba207c96d2f04e5dd094c
https://doi.org/10.1038/s41386-019-0356-1

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

Autor: Magdalena Sauvage, Jill R. Crittenden, Shenyu Zhai, Cinzia Costa, Walker S. Jackson, Anne C. Smith, Veronica Ghiglieri, David E. Housman, David Sulzer, Ann M. Graybiel, Giuseppina Martella, D. James Surmeier, Takashi Kitsukawa, Eric Burguière, Karen A. Pescatore, Ellen M. Unterwald, Barbara Picconi, Hui Zhang, Morgane Thomsen, Paolo Calabresi, S. Barak Caine

Publikováno v: Neurobiology of disease
Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2021, 158, pp.105473. ⟨10.1016/j.nbd.2021.105473⟩
Neurobiology of Disease, Vol 158, Iss, Pp 105473-(2021)
Neurobiology of disease, 158:105473
Elsevier
Neurobiology of Disease, 2021, 158, pp.105473. ⟨10.1016/j.nbd.2021.105473⟩

CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntingtons disease and le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9d40a8e94ed843df213514512c582c
http://europepmc.org/articles/PMC8486000

The Mesocorticolimbic Circuit in Drug Dependence and Reward — a Role for the Extended Amygdala?

Autor: Patricia Robledo, S. Barak Caine, George F. Koob, Athina Markou

Publikováno v: Limbic Motor Circuits and Neuropsychiatry ISBN: 9780429274411

The mesocorticolimbic dopamine (DA) system innervates the region of the nucleus accumbens in the anterior part of the basal forebrain and appears to play a critical role in mediating not only the acute reinforcing effects of the drugs but also the mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1aab5bb6b62716d8804afbbec1abdb2e
https://doi.org/10.1201/9780429274411-9

Effects of the GLP-1 Agonist Exendin-4 on Intravenous Ethanol Self-Administration in Mice

Autor: S. Barak Caine, Morgane Thomsen, Gunnar Sørensen

Publikováno v: Alcoholism: Clinical and Experimental Research. 40:2247-2252

Background Glucagon-like peptide 1 (GLP-1) receptor agonists have been shown to decrease ethanol (EtOH) drinking in rodent assays. The GLP-1 system also powerfully modulates food and fluid intake, gastrointestinal functions, and metabolism. To begin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5226ed95a5d6ce069e27b8c45610f9c
https://doi.org/10.1111/acer.13199