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Supplementary Table 4, Figure 8 from An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

Autor: David A. Boothman, Paul J. Hergenrother, Jinming Gao, Noelle S. Williams, Yiguang Wang, Elizabeth I. Parkinson, Malina Patel, Long-Shan Li, Joseph S. Bair, Jessica A. Kilgore, Erik A. Bey, Ying Dong, Xiumei Huang

PDF file - 7.1MB, Pharmacokinetics and metabolic stability of DNQ and �-lap in liver extracts. Supplemental Table 4. Table summarizing data in Supplemental Figure 8.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070cf9fbc5df9d1020697363c8309125
https://doi.org/10.1158/0008-5472.22391739

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Data from An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

Agents, such as β-lapachone, that target the redox enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), to induce programmed necrosis in solid tumors have shown great promise, but more potent tumor-selective compounds are needed. Here, we report that de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::228e9ede97ccd06c01396fc71f0aa782
https://doi.org/10.1158/0008-5472.c.6503331.v1

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Supplementary Table 3, Figure 3 from An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

PDF file - 668K, LD50 values for DNQ versus �-lap in various cancer cell types. Supplemental Figure 3. NQO1-dependent oxygen consumption rates (OCRs) in NSCLC cells after various doses of DNQ.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d714223bc0839d0adfc7cf1d5c4c69
https://doi.org/10.1158/0008-5472.22391742.v1

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Supplementary Figures 1-2 from An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

PDF file - 990K, Structures of quinones used in the study, including DNQ and �-lap. Supplemental Figure 2. Minimum time determination for DNQ lethality and demonstration of NQO1-mediated DNA lesion formation by alkaline comet assays.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a7ae614aab299a147e4268d0403201
https://doi.org/10.1158/0008-5472.22391754

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