Zobrazeno 1 - 10
of 401
pro vyhledávání: '"S. Bair"'
Autor:
David A. Boothman, Paul J. Hergenrother, Jinming Gao, Noelle S. Williams, Yiguang Wang, Elizabeth I. Parkinson, Malina Patel, Long-Shan Li, Joseph S. Bair, Jessica A. Kilgore, Erik A. Bey, Ying Dong, Xiumei Huang
PDF file - 7.1MB, Pharmacokinetics and metabolic stability of DNQ and �-lap in liver extracts. Supplemental Table 4. Table summarizing data in Supplemental Figure 8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070cf9fbc5df9d1020697363c8309125
https://doi.org/10.1158/0008-5472.22391739
https://doi.org/10.1158/0008-5472.22391739
Autor:
David A. Boothman, Paul J. Hergenrother, Jinming Gao, Noelle S. Williams, Yiguang Wang, Elizabeth I. Parkinson, Malina Patel, Long-Shan Li, Joseph S. Bair, Jessica A. Kilgore, Erik A. Bey, Ying Dong, Xiumei Huang
Agents, such as β-lapachone, that target the redox enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), to induce programmed necrosis in solid tumors have shown great promise, but more potent tumor-selective compounds are needed. Here, we report that de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228e9ede97ccd06c01396fc71f0aa782
https://doi.org/10.1158/0008-5472.c.6503331.v1
https://doi.org/10.1158/0008-5472.c.6503331.v1
Autor:
David A. Boothman, Paul J. Hergenrother, Jinming Gao, Noelle S. Williams, Yiguang Wang, Elizabeth I. Parkinson, Malina Patel, Long-Shan Li, Joseph S. Bair, Jessica A. Kilgore, Erik A. Bey, Ying Dong, Xiumei Huang
PDF file - 668K, LD50 values for DNQ versus �-lap in various cancer cell types. Supplemental Figure 3. NQO1-dependent oxygen consumption rates (OCRs) in NSCLC cells after various doses of DNQ.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d714223bc0839d0adfc7cf1d5c4c69
https://doi.org/10.1158/0008-5472.22391742.v1
https://doi.org/10.1158/0008-5472.22391742.v1
Autor:
David A. Boothman, Paul J. Hergenrother, Jinming Gao, Noelle S. Williams, Yiguang Wang, Elizabeth I. Parkinson, Malina Patel, Long-Shan Li, Joseph S. Bair, Jessica A. Kilgore, Erik A. Bey, Ying Dong, Xiumei Huang
PDF file - 990K, Structures of quinones used in the study, including DNQ and �-lap. Supplemental Figure 2. Minimum time determination for DNQ lethality and demonstration of NQO1-mediated DNA lesion formation by alkaline comet assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a7ae614aab299a147e4268d0403201
https://doi.org/10.1158/0008-5472.22391754
https://doi.org/10.1158/0008-5472.22391754
Autor:
David A. Boothman, Paul J. Hergenrother, Jinming Gao, Noelle S. Williams, Yiguang Wang, Elizabeth I. Parkinson, Malina Patel, Long-Shan Li, Joseph S. Bair, Jessica A. Kilgore, Erik A. Bey, Ying Dong, Xiumei Huang
PDF file - 514K, NQO1-dependent nucleotide depletion in response to DNQ. Supplemental Figure 5. PARP1 hyperactivation is essential for NQO1-dependent ATP loss.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8555aee53af7fe2998a271500a09e0c
https://doi.org/10.1158/0008-5472.22391751.v1
https://doi.org/10.1158/0008-5472.22391751.v1
Autor:
David A. Boothman, Paul J. Hergenrother, Jinming Gao, Noelle S. Williams, Yiguang Wang, Elizabeth I. Parkinson, Malina Patel, Long-Shan Li, Joseph S. Bair, Jessica A. Kilgore, Erik A. Bey, Ying Dong, Xiumei Huang
PDF file - 585K, NQO1 activity determinations using various quinone substrates used throughout this study. Supplemental Table 2. Relationship of NQO1 activities and doses required for equitoxicities, LD99 values.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e5f222a7ebecd352415cf19497e8e6
https://doi.org/10.1158/0008-5472.22391736
https://doi.org/10.1158/0008-5472.22391736
Autor:
David A. Boothman, Paul J. Hergenrother, Jinming Gao, Noelle S. Williams, Yiguang Wang, Elizabeth I. Parkinson, Malina Patel, Long-Shan Li, Joseph S. Bair, Jessica A. Kilgore, Erik A. Bey, Ying Dong, Xiumei Huang
PDF file - 133K, A detailed description of all Materials and Methods used in the Supplemental Figures and Tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b9ed86d7b4b03dc0ff84f1677ca3b3
https://doi.org/10.1158/0008-5472.22391745
https://doi.org/10.1158/0008-5472.22391745
Autor:
David A. Boothman, Paul J. Hergenrother, Jinming Gao, Noelle S. Williams, Yiguang Wang, Elizabeth I. Parkinson, Malina Patel, Long-Shan Li, Joseph S. Bair, Jessica A. Kilgore, Erik A. Bey, Ying Dong, Xiumei Huang
PDF file - 533K, Intracellular ER Calcium release is required for NQO1-dependent lethality after DNQ. Supplemental Figure 7. NQO1-dependent therapeutic window in vitro of DNQ in NSCLC cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bc0c67eeb8e875a52ea6a36dedd5e2
https://doi.org/10.1158/0008-5472.22391748
https://doi.org/10.1158/0008-5472.22391748
Publikováno v:
Environmental Science & Policy. 120:53-62
Reservoirs in arid regions often provide critical water storage but little is known about their greenhouse gas (GHG) footprint. While there is growing appreciation of the role reservoirs play as GHG sources, there is a lack of understanding of GHG em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d8599cbbbf7067f33e1bbb847259327
https://doi.org/10.1016/j.envsci.2021.02.006
https://doi.org/10.1016/j.envsci.2021.02.006
Autor:
Kristin Hoelting, Joshua M. Morse, Rachelle Gould, Doreen E. Martinez, Rina S. Hauptfeld, Amanda E. Cravens, Sara Breslow, Lucas S. Bair, Rudy M. Schuster, Michael C. Gavin
Many cultural benefits of ecosystems are difficult to capture in standard ecosystem services (ES) assessments. Scholars and practitioners often respond to this gap by seeking to develop new scientific methods to capture and integrate the plural value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9a91e6abfbdfcd2e79027cc4e22d5d9
https://doi.org/10.31235/osf.io/dpbe3
https://doi.org/10.31235/osf.io/dpbe3