Zobrazeno 1 - 10
of 32
pro vyhledávání: '"S. B. Marley"'
Publikováno v:
Leukemialymphoma. 2(5)
In long-term culture (LTBMC) of marrow from patients with myelodysplastic syndromes (MDS) abnormal patterns of growth, dysplastic cell morphology and cytogenetic changes present at initiation of culture persisted, providing a model in which to invest
Autor:
Joanna Nicholls, J. F. Apperley, Paul Tait, Long R. Jiao, Nataša Levičar, C. Smadja, John C. Davis, Francesco Dazzi, Nagy A. Habib, S. B. Marley, Madhava Pai, Myrtle Y. Gordon, Steen Lindkaer Jensen
Publikováno v:
Cell Proliferation. 41:115-125
Evidence is growing in support of the role of stem cells as an attractive alternative in treatment of liver diseases. Recently, we have demonstrated the feasibility and safety of infusing CD34(+) adult stem cells; this was performed on five patients
Publikováno v:
British Journal of Haematology. 125:500-511
We investigated the role of the phosphatidylinositol-3 kinase (PI-3K) pathway in regulating the proliferation of primary chronic myeloid leukaemia (CML) progenitor cells by using imatinib to inhibit the activity of p210(Bcr-Abl). The effect of imatin
Autor:
S Lloyd, D. X. Nguyen, J.L. Lewis, Francis H. Grand, Myrtle Y. Gordon, R. J. Davidson, S. B. Marley, John M. Goldman
Publikováno v:
The Hematology Journal. 1:77-86
Introduction: The function of CD34, a transmembrane sialomucin expressed by human haematopoietic progenitor cells, is poorly understood. Its structure suggests it may act as a cell adhesion and signalling molecule. Materials and methods: KGIa cells a
Autor:
Inderjeet Dokal, I. A. G. Roberts, Myrtle Y. Gordon, J. M. Goldman, S. B. Marley, R. J. Davidson, J. L. Lewis
Publikováno v:
British Journal of Haematology. 106:162-166
There are considerable differences in haemopoietic activity between young children and adults on the one hand, and between adults and the elderly on the other. A fundamental unanswered question is whether these differences relate to discrete stages o
Autor:
Abdul Shlebak, I. A. G. Roberts, J. M. Goldman, Myrtle Y. Gordon, R. J. Davidson, S. B. Marley
Publikováno v:
Bone Marrow Transplantation. 23:131-136
Some of the factors that may influence the number and quality of cord blood haematopoietic progenitor cells available for transplantation have been investigated including site of collection, delayed processing after collection and cryopreservation pr
Autor:
S. B. Marley, J. L. Lewis, Myrtle Y. Gordon, R. J. Davidson, S. Iqbal, D. X. Nguyen, Andrew Chase, Francis H. Grand, J. M. Goldman
Publikováno v:
Genes, Chromosomes and Cancer. 23:109-115
The t(9;22) translocation resulting in the fusion of BCR and ABL genes is pathognomonic in chronic myeloid leukemia (CML) and may be investigated at the molecular level using fluorescence in situ hybridization (FISH). Two-color BCR-ABL probes visuali
Autor:
R. J. Davidson, John M. Goldman, J. L. Lewis, S. B. Marley, Francis H. Grand, D. X. Nguyen, Myrtle Y. Gordon, T. A. S. Amos
Publikováno v:
Journal of Clinical Investigation. 102:710-715
The biological target for interferon (IFN)-alpha in chronic myeloid leukemia (CML) is unknown, but one possibility is that amplification of granulocyte-macrophage colony-forming cells (CFU-GM) is reduced. Replating CFU-GM colonies and observing secon
Publikováno v:
Cytokine. 10:49-54
Interleukin 3 (IL-3) and stem cell factor (SCF) are both important regulators of early haemopoietic cell development. Here, we have compared their effects or the kinetics of erythroid burst formation by BFU-E in normal adult bone marrow. We grew the
Publikováno v:
Bone Marrow Transplantation. 20:409-413
CD34 positive (CD34+) cell selection is increasingly used for a number of important applications including gene therapy studies, ex vivo expansion and purging. However there are no data regarding the use of different technologies for CD34+ cell selec