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Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca2+ elevation associated with age-dependent excitotoxicity

Autor: Olivier Thibault, J. Staton, S. Attucci, Philip W. Landfield, F. Moroni, G. V. Clodfelter, Nada M. Porter

Publikováno v: Neuroscience. 112:183-194

It has been recognized for some years that a prolonged Ca 2+ elevation that is predictive of impending cell death develops in cultured neurons following excitotoxic insult. In addition, neurons exhibit enhanced sensitivity to excitotoxic insult with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ee46d3c051f13c68230d7fd0b70532
https://doi.org/10.1016/s0306-4522(02)00002-7

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Preliminary studies for the establishment of a model of CFTR-deficient piglets

Publikováno v: 8. Journées de Recherche Respiratoire
8. Journées de Recherche Respiratoire, Oct 2013, Montpellier, France. 2013
Revue des Maladies Respiratoires
Revue des Maladies Respiratoires, Elsevier Masson, 2014, 31 (7), pp.672
18. Congrès de Pneumologie de Langue Française
Revue des Maladies Respiratoires, Elsevier Masson, 2014, 18ème Congrès de Pneumologie de Langue Française, 31 (7), pp.672. ⟨10.1016/j.rmr.2014.04.064⟩

National audience; Introduction.– Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the Cystic Fibrosis Trans membrane conductance Regulator (CFTR) gene. The lack of an animal model with lung abnormalities similar to those ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5438ab343fde148fe41d69be1f56ddf2
https://hal.inrae.fr/hal-02810478

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Farnesyl Pyrophosphate Synthase from White Lupin: Molecular Cloning, Expression, and Purification of the Expressed Protein

Autor: Patrick J. Gulick, Ragai K. Ibrahim, S.M. Aitken, S. Attucci

Publikováno v: Archives of Biochemistry and Biophysics. 321:493-500

Plants produce a variety of sesquiterpenoid compounds with diverse biological functions, whose synthesis is initiated by farnesyl pyrophosphate synthase [EC 2.5.1.1, EC 2.5.1.10]. The lack of availability of molecular tools to analyze this enzyme has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba5e269df24e1577c020c85725be399
https://doi.org/10.1006/abbi.1995.1422

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Antimicrobial potential of egg Yolk ovoinhibitor, a multidomain Kazal-like inhibitor of chicken egg

Autor: Valérie Labas, Yves Nys, Gwenaelle Le Blay, S. Attucci, Joël Gautron, Magali Berges, Marie-Christine Bourin, Sophie Réhault-Godbert

Publikováno v: Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry, American Chemical Society, 2011, 59 (23), pp.12368-12374. ⟨10.1021/jf203339t⟩

Chicken egg ovoinhibitor is a multidomain Kazal-type serine protease inhibitor with unknown function. Comparison of expression between different tissues indicated that ovoinhibitor is highly expressed in the magnum and liver followed by the uterus, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad0374d46e54886dc0827457812c25f
https://hal.archives-ouvertes.fr/hal-01129593

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Metabotropic glutamate receptors stimulate phospholipase D via different pathways in the adult and neonate rat hippocampus

Autor: S, Attucci, S, Albani-Torregrossa, F, Moroni, D E, Pellegrini-Giampietro

Publikováno v: Neurochemical research. 26(10)

In order to characterize the ontogenetic profile of metabotropic glutamate (mGlu) receptors coupled to phospholipase D (PLD) we examined the effects of selected mGlu agents on PLD activity in immature and adult rat hippocampus. The group I mGlu recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20ec468357e76a0f0d8be027e8d97b48
https://pubmed.ncbi.nlm.nih.gov/11700958

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Presynaptic kynurenate-sensitive receptors inhibit glutamate release

Autor: R, Carpenedo, A, Pittaluga, A, Cozzi, S, Attucci, A, Galli, M, Raiteri, F, Moroni

Publikováno v: The European journal of neuroscience. 13(11)

Kynurenic acid is a tryptophan metabolite provided with antagonist activity on ionotropic glutamate and alpha7 nicotinic acetylcholine receptors. We noticed that in rats with a dialysis probe placed in the head of their caudate nuclei, local administ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d63bad6dae183d5d6a8077f09829eec
https://pubmed.ncbi.nlm.nih.gov/11422455

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Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges

Autor: S, Attucci, V, Carlà, G, Mannaioni, F, Moroni

Publikováno v: British journal of pharmacology. 132(4)

1. We measured the effects of agonists and antagonists of metabotropic glutamate (mGlu) receptors (types 1 and 5) on NMDA-induced depolarization of mouse cortical wedges in order to characterize the mGlu receptor type responsible for modulating NMDA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4bbc381ee0a93d63da040415078d5de5
https://pubmed.ncbi.nlm.nih.gov/11181420

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Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: focus on (2R,1'S,2'R,3'S)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine versus 3, 5-dihydroxyphenylglycine

Autor: S, Albani-Torregrossa, S, Attucci, M, Marinozzi, R, Pellicciari, F, Moroni, D E, Pellegrini-Giampietro

Publikováno v: Molecular pharmacology. 55(4)

Metabotropic glutamate (mGlu) receptors coupled to phospholipase D (PLD) appear to be distinct from any known mGlu receptor subtype linked to phospholipase C or adenylyl cyclase. The availability of antagonists is necessary for understanding the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f5a9b976223653e3264336ace7700ee
https://pubmed.ncbi.nlm.nih.gov/10101028

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