Diffusion-weighted MRI for detecting prostate tumour in men at increased genetic risk

Autor: Nandita M. deSouza, Veronica A. Morgan, Elizabeth Bancroft, S. Aslam Sohaib, Sharon L. Giles, Zsofia Kote-Jarai, Elena Castro, Steven Hazell, Maysam Jafar, Rosalind Eeles

Publikováno v: European Journal of Radiology Open, Vol 1, Iss C, Pp 22-27 (2014)

Background: Diffusion-weighted (DW)-MRI is invaluable in detecting prostate cancer. We determined its sensitivity and specificity and established interobserver agreement for detecting tumour in men with a family history of prostate cancer stratified

Externí odkaz: https://doaj.org/article/f2d7f12ccf634c44afb1c42b39c20658

Psychosocial effects of whole-body MRI screening in adult high-risk pathogenic TP53 mutation carriers: A case-controlled study (SIGNIFY)

Autor: Lucy Side, Emma Brown, Alexander Dias, Lauren Limb, Helen Hanson, Anthony Chamberlain, Sarah Benafif, Jeanette Rothwell, D. Gareth Evans, S. Aslam Sohaib, Rosalind A. Eeles, Jennifer Pope, Sibel Saya, Lisa Walker, Natalie Taylor, Richard W. Whitehouse, Diana Eccles, Christos Mikropoulos, Julian Barwell, Elizabeth Page, Martin O. Leach, Elizabeth Bancroft, Sarah Thomas, Balashanmugam Rajashanker, Dow-Mu Koh, Alan Donaldson, Susan Shanley, Jackie Cook, David J. Gallagher, Fiona J. Gilbert, Louise Izatt, Leslie G. Walker, Vicki Wiles

Publikováno v: Journal of Medical Genetics
Bancroft, E K, Saya, S, Brown, E, Thomas, S, Taylor, N, Rothwell, J, Pope, J, Chamberlain, A, Page, E, Benafif, S, Hanson, H, Dias, A, Mikropoulos, C, Izatt, L, Side, L, Walker, L, Donaldson, A, Cook, J A, Barwell, J, Wiles, V, Limb, L, Eccles, D M, Leach, M O, Shanley, S, Gilbert, F J, Gallagher, D, Rajashanker, B, Whitehouse, R W, Koh, D-M, Sohaib, S A, Evans, D G, Eeles, R A & Walker, L G 2019, ' Psychosocial effects of whole-body MRI screening in adult high-risk pathogenic TP53 mutation carriers : a case-controlled study (SIGNIFY) ', Journal of Medical Genetics . https://doi.org/10.1136/jmedgenet-2019-106407

BackgroundGermline TP53 gene pathogenic variants (pv) cause a very high lifetime risk of developing cancer, almost 100% for women and 75% for men. In the UK, annual MRI breast screening is recommended for female TP53 pv carriers. The SIGNIFY study (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0c1323590d229ac1e784c7a7c0fdaa
https://eprints.soton.ac.uk/434755/

Diffusion-weighted MRI for detecting prostate tumour in men at increased genetic risk

Autor: Rosalind A. Eeles, Sharon L. Giles, Veronica A. Morgan, Nandita M. deSouza, S. Aslam Sohaib, Maysam Jafar, Elizabeth Bancroft, Elena Castro, Steven Hazell, Zsofia Kote-Jarai

Publikováno v: European Journal of Radiology Open
European Journal of Radiology Open, Vol 1, Iss C, Pp 22-27 (2014)

Highlights • Endorectal T2W + DW-MRI is potentially useful for prostate cancer screening. • MRI is specific for detecting prostate cancer in men with increased genetic risk. • Detection of prostate cancer in men at genetically low risk with MRI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7f19598340d0c649920cf1edd313f4
http://europepmc.org/articles/PMC4687444

The Role of Imaging in the Diagnosis, Staging, and Management of Testicular Cancer

Autor: Janet E. Husband, S. Aslam Sohaib, Dow-Mu Koh

Publikováno v: American Journal of Roentgenology. 191:387-395

OBJECTIVE. The objective of this article is to describe recent developments in imaging patients with testicular germ cell tumors (GCTs). CONCLUSION. Most patients with testicular GCTs can now be expected to be cured, so the focus on management moves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477b8506f9cd9576b73a10127ac59e96
https://doi.org/10.2214/ajr.07.2758

Outcome of early detection and radiotherapy for occult spinal cord compression

Autor: Robert Huddart, S. Aslam Sohaib, Vincent Khoo, Alan Horwich, Rosalind A. Eeles, Yolanda Barbachano, David P. Dearnaley, Ramachandran Venkitaraman, Chris Parker

Publikováno v: Radiotherapy and Oncology. 85:469-472

Retrospective analysis in 150 patients with metastatic prostate cancer was conducted to determine whether early detection with MRI spine and treatment of clinically occult spinal cord compromise (SCC) facilitate preservation of neurologic function. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1c9ff5e207e8a2e5cf1c667543f16a
https://doi.org/10.1016/j.radonc.2007.10.043