Zobrazeno 1 - 10
of 107
pro vyhledávání: '"S. Apparsundaram"'
Publikováno v:
Biochemical Society Transactions. 29:711-716
In cholinergic neurons, a specific requirement for precursor choline in the biosynthesis of acetylcholine (ACh) is thought to be sustained by a presynaptic, hemicholinium-3 (HC-3)-sensitive choline transporter (CHT). This transporter exhibits micromo
Akademický článek
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Autor:
Richard A. Bond, S Apparsundaram, Terry P. Kenakin, M F Hyek, Carmelo A. Milano, Lee F. Allen, T. D. Johnson, T. R. McMinn, P. Leff, Howard A. Rockman
Publikováno v:
Nature. 374:272-276
G-PROTEIN-COUPLED receptors are thought to have an inactive conformation (R), requiring an agonist-induced conformational change for receptor/G-protein coupling1–3. But new evidence suggests a two-state model4–19 in which receptors are in equilib
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
Presynaptic, cocaine- and antidepressant-sensitive norepinephrine (NE) transporters (NETs) dictate levels of extracellular NE after vesicular release. Recent studies suggest that G protein-coupled receptors linked to protein kinase C (PKC) down-regul
Publikováno v:
The Journal of comparative neurology. 420(2)
Norepinephrine (NE) transporters (NETs) constitute the primary mechanism for inactivation of synaptically released NE, are targets for multiple antidepressants and psychostimulants, and have been reported to be deficient in affective and autonomic di
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(2)
Using SK-N-SH cells, we observe that muscarinic acetylcholine receptor activation by methacholine (MCh) rapidly and selectively diminishes l-NE transport capacity (Vmax) with little or no change in norepinephrine (NE) Km and without apparent effects
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(2)
Norepinephrine (NE) transporters (NETs) found in the neuronal plasma membrane mediate the removal of NE from the extracellular space, limiting the activation of adrenoceptors at noradrenergic synapses. Our previous studies with the noradrenergic neur
Publikováno v:
Molecular pharmacology. 54(4)
A small subset of neurons in the nematode Caenorhabditis elegans utilizes the catecholamine dopamine (DA) as a neurotransmitter to control or modulate movement and egg-laying. Disruption of DA-mediated behaviors represents a potentially powerful stra
Autor:
R D, Blakely, S, Apparsundaram
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 42
Autor:
S, Apparsundaram, D C, Eikenburg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(2)
This study examines the effects of acute incorporation of epinephrine (EPI) into cardiac catecholamine stores and chronic elevation of plasma EPI concentrations on sympathetic neurotransmission and adrenoceptor modulation in the rat heart. Chronic el