Výsledky vyhledávání - "S. Afshinjavid"

Expanding the Chemical Space of Withaferin A by Incorporating Silicon To Improve Its Clinical Potential on Human Ovarian Carcinoma Cells

Autor: Carolina P. Reyes, Farideh A. Javid, Isabel L. Bazzocchi, Ignacio A. Jiménez, Nayra R. Perestelo, Gabriel G. Llanos, Kartheek Sooda, Ángel Amesty, S. Afshinjavid

Publikováno v: Journal of Medicinal Chemistry. 62:4571-4585

Ovarian cancer represents the seventh most commonly diagnosed cancer worldwide. Herein, we report on the development of a withaferin A (WA)-silyl ether library with 30 analogues reported for the first time. Cytotoxicity assays on human epithelial ova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7966454cc2270ea49cff6c01dd911962
https://doi.org/10.1021/acs.jmedchem.9b00146

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Aryne-Mediated Arylation of Hantzsch Esters: Access to Highly Substituted Aryl-dihydropyridines, Aryl-tetrahydropyridines and Spiro[benzocyclobutene-1,1′-(3′,4′-dihydropyridines)]

Autor: Christopher R. Jones, S. Afshinjavid, David Palomas, Weitao Sun, Farideh A. Javid, Piera Trinchera, Rachel Crespo-Otero, Nada Kurdi

Publikováno v: Synthesis. 50:4591-4605

This is a full account of our studies into the generation of highly functionalised 2-aryl-1,2-dihydropyridines and 2-methylene-3-aryl-1,2,3,4-tetrahydropyridines via intermolecular aryne ene reactions of Hantzsch esters. Furthermore, exposure to exce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fa719db7dce96aad2659e2d931e7641
https://doi.org/10.1055/s-0037-1611065

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Further investigation of the effects of 5-hydroxytryptamine, 8-OH-DPAT and DOI to mediate contraction and relaxation responses in the intestine and emesis in Suncus murinus

Autor: Farideh A. Javid, S. Afshinjavid, Charles C. Horn

Publikováno v: European Journal of Pharmacology. 821:79-87

5-HT receptors are implicated in many gastrointestinal disorders. However, the precise role of 5-HT in mediating GI responses in Suncus murnius is still unclear. Therefore in this study, the effects of 5-HT and its agonists were investigated in Suncu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b3b03e225afbf7ab4051b4d2a80cee
https://doi.org/10.1016/j.ejphar.2017.12.051

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Fluoxetine selectively induces p53-independent apoptosis in human colorectal cancer cells

Autor: Monika Marcinkute, Amos A. Fatokun, S. Afshinjavid, Farideh A. Javid

Publikováno v: European Journal of Pharmacology. 857:172441

Fluoxetine has been shown to induce anti-tumour activity. The aim of this study was to determine the effect of fluoxetine on HCT116+/+ and p53 gene-depleted HCT116-/- human colorectal cancer cells and the mechanisms, including potential p53-dependenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dced48d2c19d56fd9777df597638d9a4
https://doi.org/10.1016/j.ejphar.2019.172441

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ChemInform Abstract: Synthesis, Conformation and Antiproliferative Activity of Isothiazoloisoxazole 1,1-Dioxides

Autor: Simon J. Coles, Farideh A. Javid, S. Afshinjavid, Craig R. Rice, Peter N. Horton, Joanna Blackburn, Arnaud Pitard, Karl Hemming, G. Molyneux, Michael I. Page

Publikováno v: ChemInform. 47

Sixteen new isothiazoloisoxazole 1,1-dioxides, one new isothiazolotriazole and one new isothiazolopyrazole have been synthesised by using 1,3-dipolar cycloadditions to isothiazole 1,1-dioxides. One sub-set of these isothiazoloisoxazoles showed low μ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95cd928bac86c56bbfb751a6e28a8d84
https://doi.org/10.1002/chin.201625140

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Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

Autor: Farideh A. Javid, Alessia Ligresti, Roberta Verde, S. Afshinjavid, Roger M. Phillips

Publikováno v: European journal of pharmacology 775 (2016): 1–14. doi:10.1016/j.ejphar.2016.02.010
info:cnr-pdr/source/autori:Javid F.A.; Phillips R.M.; Afshinjavid S.; Verde R.; Ligresti A./titolo:Cannabinoid pharmacology in cancer research: A new hope for cancer patients?/doi:10.1016%2Fj.ejphar.2016.02.010/rivista:European journal of pharmacology/anno:2016/pagina_da:1/pagina_a:14/intervallo_pagine:1–14/volume:775

Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and anxiety disorders, movement disorders such as Parkinson'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e019972b7b9026e31dca91c9dd707538
https://pubmed.ncbi.nlm.nih.gov/26852955

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The effect of CBD, CBG and a combination of CBD plus CBG on Haccat human skin carcinoma cells (1048.19)

Autor: S. Afshinjavid, Farideh A. Javid

Publikováno v: The FASEB Journal. 28

The effect of CBD, CBG and a combination of CBD plus CBG on Haccat human skin carcinoma cells Cannabinoid pharmacology has received attention in cancer research for their potential in combating can...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49b0c6af0d6ae6bf393d65a6844ccf1a
https://doi.org/10.1096/fasebj.28.1_supplement.1048.19

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The effect of clearance upon friction of large diameter hip resurfacing prostheses using blood, clotted blood and bovine serum as lubricants

Autor: Mansour Youseffi, S. Afshinjavid

Publikováno v: IFMBE Proceedings ISBN: 9783642038884

Total hip joint implantation is an effective solution for reducing pain and ailing induced by arthritis or other diseases at the hip joint. Hence, a conventional metal on polyethylene (PE) bearing device has been introduced since late 1950’s for im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7fdc3d15e894ebdaa065c453092d869
https://doi.org/10.1007/978-3-642-03889-1_112

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