Zobrazeno 1 - 10
of 40
pro vyhledávání: '"S. Adriaan Nelemans"'
Publikováno v:
Mediators of Inflammation, Vol 2005, Iss 6, Pp 317-330 (2005)
Recently it has become possible to investigate expression of all human genes with microarray technique. The authors provide arguments to consider peripheral white blood cells and in particular lymphocytes as a model for the investigation of pathophys
Externí odkaz:
https://doaj.org/article/50a63eb95e70402e95451741ea9982d7
Autor:
Karen M. Ens, Jelte-Maarten Penninks, Hoeke A. Baarsma, S. Adriaan Nelemans, Dedmer Schaafsma, Reinoud Gosens, Gerald L. Stelmack, Bart G. J. Dekkers, Johan Zaagsma, Erin Frohwerk, Karol D. McNeill, Herman Meurs, Andrew J. Halayko, Pawan K. Sharma
Publikováno v:
American journal of physiology-Cell physiology, 293(1), C429-C439. AMER PHYSIOLOGICAL SOC
We have previously demonstrated that long-term exposure of bovine tracheal smooth muscle (BTSM) strips to insulin induces a functional hypercontractile phenotype. To elucidate molecular mechanisms by which insulin might induce maturation of contracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f47b05def7a7ef4adb486c27c33d61
https://doi.org/10.1152/ajpcell.00502.2006
https://doi.org/10.1152/ajpcell.00502.2006
Autor:
Herman Meurs, Iris B. Hovens, Mark Boterman, S. Adriaan Nelemans, Johan Zaagsma, Anne-Margreet De Jong, Jelte-Maarten Penninks, Dedmer Schaafsma
Publikováno v:
British Journal of Pharmacology. 147:737-743
In airway smooth muscle (ASM), full and partial muscarinic receptor agonists have been described to have large differences in their ability to induce signal transduction, including Ca2+-mobilization. Despite these differences, partial agonists are ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::920cd2184539fab5ee59090a7e0c7571
https://doi.org/10.1038/sj.bjp.0706665
https://doi.org/10.1038/sj.bjp.0706665
Autor:
Haukeline H. Volders, Jaap Oostendorp, Eugene R. Bleecker, Henk F. Kauffman, S. Adriaan Nelemans, Hajo Jongepier, Dirkje S. Postma, Johan Zaagsma, Deborah A. Meyers, Herman Meurs, H. Marike Boezen
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 172(3), 322-328. AMER THORACIC SOC
Single-nucleotide polymorphisms of the beta(2)-adrenergic receptor gene and its 5 ' promoter have been associated with differences in receptor function and desensitization. Linkage disequilibrium may account for inconsistencies in reported effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db5e72ebda3d4e6aba4a0f9dc21bd47
https://doi.org/10.1164/rccm.200409-1162oc
https://doi.org/10.1164/rccm.200409-1162oc
Publikováno v:
European Journal of Pharmacology, 495(1), 75-81. ELSEVIER SCIENCE BV
Although a prominent role for protein kinase C (PKC) in the cross-talk between the phosphoinositide pathway and beta(2)-adrenoceptor signalling has been indicated, modulation of beta(3)-adrenoceptor function by PKC has not been studied thus far. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f547dfe529921a94938126db8ffe136
https://research.rug.nl/en/publications/e06eaca0-b762-4b1a-b0bf-7e1fbe6b65a9
https://research.rug.nl/en/publications/e06eaca0-b762-4b1a-b0bf-7e1fbe6b65a9
Autor:
Mechteld M. Grootte Bromhaar, S. Adriaan Nelemans, Herman Meurs, Bart Vrugt, Johan Zaagsma, Dedmer Schaafsma, Reinoud Gosens
Publikováno v:
European Journal of Pharmacology, 494(1), 73-76. ELSEVIER SCIENCE BV
Growth factors have been implicated in the pathophysiology of asthma. However, the putative effects of these growth factors on human airway smooth muscle tone are still largely unknown. We performed contraction experiments using human bronchial smoot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5c4808fdc2f623cac1116389383c90
https://doi.org/10.1016/j.ejphar.2004.04.035
https://doi.org/10.1016/j.ejphar.2004.04.035
Autor:
Annet Tonkes, Herman Meurs, S. Adriaan Nelemans, Johan Zaagsma, Mechteld M. Grootte Bromhaar, Dedmer Schaafsma, Reinoud Gosens
Publikováno v:
British Journal of Pharmacology. 141:943-950
1. Airway smooth muscle (ASM) cells are known to switch from a contractile to a proliferative and synthetic phenotype in culture in response to serum and growth factors. Phenotype switching in response to contractile agonists, however, is poorly char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::935977c33d2d6b8e6843c7b946e9540d
https://doi.org/10.1038/sj.bjp.0705709
https://doi.org/10.1038/sj.bjp.0705709
Publikováno v:
European Journal of Pharmacology, 483(1), 71-78. ELSEVIER SCIENCE BV
This study aims to investigate the role of Rho-kinase in phenotype switching and proliferation of bovine tracheal smooth muscle. To induce different phenotypic states, bovine tracheal smooth muscle strips were cultured (8 days) in 10% foetal bovine s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1972c986057679bf771e851a2238092
https://doi.org/10.1016/j.ejphar.2003.10.027
https://doi.org/10.1016/j.ejphar.2003.10.027
Autor:
Mechteld M. Grootte Bromhaar, S. Adriaan Nelemans, Herman Meurs, Reinoud Gosens, Johan Zaagsma, Maartje Hiemstra
Publikováno v:
European Journal of Pharmacology, 481(1), 125-131. ELSEVIER SCIENCE BV
This study aims to investigate the effects of insulin on bovine tracheal smooth muscle phenotype in vitro. Contractility of muscle strips and DNA-synthesis ([3 H]thymidine incorporation) of isolated cells were used as parameters for smooth muscle phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc6e1f024c7777fa0ea02f40de3d77a
https://research.rug.nl/en/publications/8f609d1a-20ec-48eb-94ed-cb4e41b2ec15
https://research.rug.nl/en/publications/8f609d1a-20ec-48eb-94ed-cb4e41b2ec15
Autor:
Sue McKay, Johan Zaagsma, Herman Meurs, S. Adriaan Nelemans, Reinoud Gosens, Mechteld M. Grootte Bromhaar
Publikováno v:
British Journal of Pharmacology. 137:459-466
1. The present study aims to investigate whether phenotypic changes, reported to occur in cultured isolated airway smooth muscle (ASM) cells, are of relevance to intact ASM. Moreover, we aimed to gain insight into the signalling pathways involved. 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c6dd2d9f3e35c3a6f43ff0f2e939297
https://doi.org/10.1038/sj.bjp.0704889
https://doi.org/10.1038/sj.bjp.0704889