Výsledky vyhledávání - "S. A. Strugnell"

1α,24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidism

Autor: S. A. Strugnell, Omar Akhouayri, J. C. Knutson, Alice Arabian, René St-Arnaud, Vionnie W.C. Yu

Publikováno v: Journal of endocrinological investigation. 31(8)

Background: Vitamin D compounds are effective in managing elevated PTH levels in secondary hyperparathyroidism (SHPT) of renal failure. However, undesired increases in serum calcium and phosphorus associated with compounds such as calcitriol [1,25(OH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6e30a8806072910a253c0bd917caad
https://pubmed.ncbi.nlm.nih.gov/18852532

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Growth inhibition of cancer cells by an active metabolite of a novel vitamin D prodrug

Autor: Y R, Wang, D P, Wigington, S A, Strugnell, J C, Knutson

Publikováno v: Anticancer research. 25(6B)

Active vitamin D compounds have been developed that maintain antiproliferative properties with low calcemic activity. BCI-210, a novel vitamin D pro-drug developed in our laboratory, is activated through side chain hydroxylation and possesses lower c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8ceaea8312005a10278ff0871c0cb80
https://pubmed.ncbi.nlm.nih.gov/16309237

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Pamidronate and 1,24(S)-dihydroxyvitamin D2 synergistically inhibit the growth of myeloma, breast and prostate cancer cells

Autor: D P, Wigington, S A, Strugnell, J C, Knutson

Publikováno v: Anticancer research. 25(3B)

Bisphosphonates have proven to be effective in the management of multiple myeloma and bone metastases secondary to breast and prostate carcinoma. Vitamin D compounds are important modulators of cellular proliferation and differentiation. 1,24(S)-dihy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c64a59e9c35c9a6a06e31092e677ab26
https://pubmed.ncbi.nlm.nih.gov/16158925

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Combination study of 1,24(S)-dihydroxyvitamin D2 and chemotherapeutic agents on human breast and prostate cancer cell lines

Autor: D P, Wigington, C M, Urben, S A, Strugnell, J C, Knutson

Publikováno v: Anticancer research. 24(5A)

Vitamin D compounds are important modulators of cellular proliferation and differentiation, with potential utility as anticancer drugs. 1,24(S)-Dihydroxyvitamin D2 [1,24(OH)2D2] is a naturally occurring active vitamin D compound with low calcemic act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc2e39882f4613dec689c9d1f2b1358a
https://pubmed.ncbi.nlm.nih.gov/15517895

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DNA bending is induced by binding of vitamin D receptor-retinoid X receptor heterodimers to vitamin D response elements

Autor: C, Kimmel-Jehan, H M, Darwish, S A, Strugnell, F, Jehan, B, Wiefling, H F, DeLuca

Publikováno v: Journal of cellular biochemistry. 74(2)

The ability of vitamin D receptor-retinoid X receptor (VDR-RXR) heterodimers to induce a DNA bend upon binding to various vitamin D response elements (VDRE) has been investigated by circular permutation and phasing analysis. Recombinant rat VDR expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abe5d4f61e7587e757dbb0938ba0c701
https://pubmed.ncbi.nlm.nih.gov/10404392

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