Výsledky vyhledávání - "S. A. Shams El-Dine"

Synthesis and biological evaluation of purine-pyrazole hybrids incorporating thiazole, thiazolidinone or rhodanine moiety as 15-LOX inhibitors endowed with anticancer and antioxidant potential

Autor: Marwa M. Abu-Serie, Alaa A. El-Tombary, S. A. Shams El-Dine, Heba A. Abd El Razik, Omaima G. Shaaban, Fawzia A. Ashour, Ola S. Afifi

Publikováno v: Bioorganic Chemistry. 87:821-837

Novel purine-pyrazole hybrids combining thiazoles, thiazolidinones and rhodanines, were designed and tested as 15-LOX inhibitors, potential anticancer and antioxidant agents. All tested compounds were found to be potent 15-LOX inhibitors with IC50 ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e2df419b8a437356b1d9e81ef25ed1
https://doi.org/10.1016/j.bioorg.2019.03.076

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Purines and triazolo[4,3-e]purines containing pyrazole moiety as potential anticancer and antioxidant agents

Autor: S. A. Shams El-Dine, Fawzia A. Ashour, Ola S. Afifi, Omaima G. Shaaban, Alaa A. El-Tombary, Marwa M. Abu-Serie, Heba A. Abd El Razik

Publikováno v: Future medicinal chemistry. 10(12)

Aim: Targeting apoptosis regulators such as caspases aiming at inducing apoptosis is an attractive strategy in cancer therapy. Materials & methods: 8-substituted purine incorporating pyrazole moiety were designed, synthesized and evaluated for their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c4897dea2832a5172d40e6a3a2e827
https://pubmed.ncbi.nlm.nih.gov/29788781

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Synthesis of some substituted furan-2(5H)-ones and derived quinoxalinones as potential anti-microbial and anti-cancer agents

Autor: Yasser S. Abdel-Ghany, Alaa A. El-Tombary, Farid S. G. Soliman, S. A. Shams El-Dine, Ahmad S. F. Belal

Publikováno v: Medicinal Chemistry Research. 20:865-876

In search for novel anti-cancer and anti-microbial agents with promising pharmacotoxicological profile, the synthesis of some substituted 4-halofuran-2(5H)-ones (8a–l, 9, 11) and derived halogenated quinoxalin-2(1H)-ones (12a–d) is described. Som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8502e68e6845476148c7b7bc58a06dff
https://doi.org/10.1007/s00044-010-9394-2

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Synthesis of Some New Antimicrobial Thiadiazolyl and Oxadiazolyl Quinoline Derivatives

Autor: Ola H. Rizk, Mona A. Mahran, El-Sebai A. Ibrahim, S. A. Shams El-Dine, S. M. El-Khawass

Publikováno v: Medicinal Chemistry Research. 14:260-273

Two series of substituted thiadiazolyl and oxadiazolylquinolines (3a-h, 4a-h, 7a-f, 8a-f and 9) were synthesized and screened for their antimicrobila activity. Some of the tested compounds showed promising activity. Compound 4b exhibited bactericidal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34a843c76a454d7f523f7ea8f37a3231
https://doi.org/10.1007/s00044-005-0138-7

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ChemInform Abstract: Reactions with Pyrrolidine-2,4-diones. Part 4. Synthesis of Some 3-Substituted 1,5-Diphenylpyrrolidine-2,4-diones as Potential Antimicrobial, Anti-HIV-1 and Antineoplastic Agents

Autor: Manal N. S. Saudi, S. A. Shams El-Dine, Fawzia A. Ashour, Farid S. G. Soliman

Publikováno v: ChemInform. 33

The condensation of 1,5-diphenylpyrrolidine-2,4-dione (1) with ethyl orthoformate yielded 3-ethoxymethylene-1,5-diphenylpyrrolidine-2,4-dione (2). Reaction of the latter with hydrazine hydrate, secondary amines 7a-c or urea afforded the corresponding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::015f7e1bbf42cc15aaf129ab29722e6b
https://doi.org/10.1002/chin.200214116

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Reactions with pyrrolidine-2,4-diones, II: New approaches to the synthesis of substituted 5,6-dihydropyrrolo[3,4-d][1,2,3]triazol-4(2H,4H)ones

Autor: Manal N. S. Saudi, M. G. Kassem, Farid S. G. Soliman, S. A. Shams El-Dine

Publikováno v: Monatshefte f�r Chemie Chemical Monthly. 121:671-675

Approaches leading to 5,6-dihydro-5,6-diphenyl-2-substituted-pyrrolo[3,4-d][1,2,3]-triazol-4(2H,4H)-ones (10) are described. The first approach consists of cyclodehydrating 3(or 4)-hydroxyimino-1,5-diphenyl-4(or 3)-(4-substituted phenylhydrazono)pyrr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58093bb1efba129192406e78936531dd
https://doi.org/10.1007/bf00809771

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Reactions with pyrrolidine-2,4-diones, Part 4: Synthesis of some 3-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial, anti-HIV-1 and antineoplastic agents

Autor: S A, Shams el-Dine, F S, Soliman, F A, Ashour, M N, Saudi

Publikováno v: Die Pharmazie. 56(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e6a22b62c73eced16572a075e58e7d1
https://pubmed.ncbi.nlm.nih.gov/11802654

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Synthesis of 5,6-Diaryl-1,2,4-triazines

Autor: Farid S. G. Soliman, A. Ibrahim El Sebai, S. A. Shams El Dine, Ibrahim M. Labouta

Publikováno v: Zeitschrift für Naturforschung B. 33:1503-1507

The synthesis of 6-(4-methoxyphenyl)-5-phenyl-3-oxo-2,3-dihydro-1,2,4-triazine (5a) from 4-methoxybenzoin, 4-methoxybenzil, or 4-methoxybenzoin semicarbazone and semi-carbazide hydrochloride is reported. The condensation of 4-methoxybenzil with thios

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4992bf13998fa9c220c3265838abb88
https://doi.org/10.1515/znb-1978-1228

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