Zobrazeno 1 - 3
of 3
pro vyhledávání: '"S. A. Shahnavaz"'
Publikováno v:
The Journal of Pathology. 190:417-422
Previous studies of oral cancer have suggested that alterations of the p53 tumour suppressor gene occur early in the precancerous stage of development. However, these observations have been based on cross-sectional assessment of abnormal p53 protein
Publikováno v:
Cancer research. 61(6)
The CDKN2A gene locus encodes two different proteins derived from alternative splicing. p16 (exons 1alpha, 2, and 3) acts as a G1 cell cycle regulator, and p14ARF (exons 1beta, 2, and 3) acts to modulate MDM2-mediated degradation of p53. Inactivation
Publikováno v:
The Journal of pathology. 190(4)
Previous studies of oral cancer have suggested that alterations of the p53 tumour suppressor gene occur early in the precancerous stage of development. However, these observations have been based on cross-sectional assessment of abnormal p53 protein