Zobrazeno 1 - 10 of 34 pro vyhledávání: '"S. A. Podzorova"'
1
New approaches to the design of analgesic medicinal substances
Autor: I. V. Rogachevskii, S. A. Podzorova, Boris V. Krylov, S. G. Terekhin, V. B. Plakhova, V. A. Penniyaynen
Publikováno v: Canadian Journal of Physiology and Pharmacology. 100:43-52
A gamma-pyrone derivative, comenic acid, activates the opioid-like receptor-mediated signaling pathway that modulates the NaV1.8 channels in the primary sensory neuron membrane. These channels are responsible for the generation of the nociceptive sig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa187591776cab2866d0be7d85cd58a0
https://doi.org/10.1139/cjpp-2021-0286
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3
A Possible Mechanism of Modulation of Slow Sodium Channels in the Sensory Neuron Membrane by Short Peptides
Autor: V. A. Penniyaynen, S. A. Podzorova, S. G. Terekhin, A. D. Kalinina, I. V. Rogachevsky, Boris V. Krylov, V. B. Plakhova
Publikováno v: Biophysics. 66:579-588
The possible mechanisms of ligand–receptor binding of arginine-containing tetrapeptides with the NaV1.8 channels in the primary sensory neuron were investigated. Ac-RERR-NH2 tetrapeptide, acting outside the neuronal membrane, was found to decrease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67341ff3bea72d7d2ee22a83136d3469
https://doi.org/10.1134/s0006350921040205
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4
The Role of Slow Sodium Channels in GABAergic and NOergic Modulation of Nociceptive Neuron Excitability
Autor: S. A. Podzorova, S. G. Terekhin, V. A. Penniyaynen, A. D. Kalinina, V. B. Plakhova, Boris V. Krylov
Publikováno v: Neuroscience and Behavioral Physiology. 51:831-836
Local voltage clamping and organotypic cultures of nervous tissue were used to study the actions of a series of agents whose activity is associated with the functioning of the GABAergic and NOergic systems on slow sodium channels. GABA was found not
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fa54a72f73ea5bea89dd31ce863ef6c
https://doi.org/10.1007/s11055-021-01140-z
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5
Possible Antinociceptive Mechanisms Triggered by Nanomolar Ouabain Concentrations in Primary Sensory Neurons
Autor: V. A. Penniyaynen, S. A. Podzorova, A. V. Ankudinov, M. M. Khalisov, Boris V. Krylov, V. B. Plakhova
Publikováno v: Neuroscience and Behavioral Physiology. 51:687-693
The responses of primary sensory neurons to subnanomolar and nanomolar ouabain concentrations, corresponding to the endogenous ouabain (EO) concentration, were studied. Atomic force microscopy (AFM) studies showed that exposure to EO led to an increa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42e2bbc942f16f14935efdce77080c80
https://doi.org/10.1007/s11055-021-01122-1
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7
An Investigation of the Effect of Colchicine on Living Fibroblasts by Atomic Force and Confocal Microscopy
Autor: K. I. Timoshchuk, M. M. Khalisov, Boris V. Krylov, V. A. Penniyaynen, A. V. Ankudinov, S. A. Podzorova
Publikováno v: Technical Physics. 65:1853-1858
Using atomic force and confocal laser scanning microscopy, the effect of colchicine (1 μg/mL) on primary culture of rat fibroblasts, causing depolymerization of tubulin microtubules, was studied. When analyzing the atomic force microscopy data, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12b4d8b7395b9456955346c0190f8139
https://doi.org/10.1134/s106378422011016x
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8
Dual mechanism of modulation of NaV1.8 sodium channels by ouabain
Autor: Ilia V. Rogachevskii, M. M. Khalisov, Boris V. Krylov, S. A. Podzorova, Alexander V. Ankudinov, V. B. Plakhova, V. A. Penniyaynen
Publikováno v: Canadian Journal of Physiology and Pharmacology. 98:785-802
In the primary sensory neuron, ouabain activates the dual mechanism that modulates the functional activity of NaV1.8 channels. Ouabain at endogenous concentrations (EO) triggers two different signaling cascades, in which the Na,K-ATPase/Src complex i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56b84bec49afa02b17ffd5648c352db8
https://doi.org/10.1139/cjpp-2020-0197
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9
PROBABLE ANALGESIC EFFECT OF SYNTHETIC TETRAPEPTIDE
Autor: S. A. Podzorova, V. A. Penniyaynen, E A Merculova, Boris V. Krylov, V. B. Plakhova, I. V. Rogachevskii
Publikováno v: Medical academic journal. 19:172-174
The aim of the study was to elucidate the molecular mechanisms of modulation of the NaV1.8 channels with a synthetic tetrapeptide (Ac-RERR-NH2). Our data suggest that this substance specifically modulates the activation gating device of these channel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b84c73208d78eaf51f2b7485929f344
https://doi.org/10.17816/maj191s1172-174
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10
Molecular mechanisms and signaling by comenic acid in nociceptive neurons influence the pathophysiology of neuropathic pain
Autor: I. V. Rogachevskii, S. A. Podzorova, V. A. Penniyaynen, Boris V. Krylov, V. B. Plakhova, S. G. Terekhin
Publikováno v: Pathophysiology. 26:245-252
Comenic acid (CA), a specific agonist of opioid-like receptors, effectively and safely relieves neuropathic pain by decreasing the NaV1.8 channel voltage sensitivity in the primary sensory neuron membrane. CA triggers downstream signaling cascades, i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2eaba0aed55d36918d944f5a475117d
https://doi.org/10.1016/j.pathophys.2019.06.003
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