The common marmoset (Callithrix jacchus): a relevant preclinical model of human (auto)immune-mediated inflammatory disease of the brain

Autor: B. A. 't Hart, J. Dunham, S. A. Jagessar, Y. S. Kap

Publikováno v: Primate Biology, Vol 3, Iss 1, Pp 9-22 (2016)

The increasing prevalence of chronic autoimmune-mediated inflammatory disorders (AIMIDs) in aging human populations creates a high unmet need for safe and effective medications. However, thus far the translation of pathogenic concepts developed in an

Externí odkaz: https://doaj.org/article/c85dcd1fdff24696bc2ec6a9dc6e4e4b

The common marmoset as an indispensable animal model for immunotherapy development in multiple sclerosis

Autor: Bert A. 't Hart, Jordon Dunham, Yolanda S. Kap, S. Anwar Jagessar

Publikováno v: Drug Discovery Today. 21(8):1200-1205

New drugs often fail in the translation from the rodent experimental autoimmune encephalomyelitis (EAE) model to human multiple sclerosis (MS). Here, we present the marmoset EAE model as an indispensable model for translational research into MS. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f4bf34b3e75b9377d3a349eab25dfe
https://doi.org/10.1016/j.drudis.2016.03.014

Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein

Autor: S. Anwar Jagessar, Bruno Gran, Bert A. 't Hart, Nicole Heijmans, Inge R. Holtman, Jon D. Laman, Bart J. L. Eggen, Elena Morandi, Sam O. Hofman, Sander I. van Kasteren, Bart W. Faber

Publikováno v: Journal of Immunology, 197(4), 1074-1088. American Association of Immunologists
Journal of Immunology, 197(4), 1074-1088. AMER ASSOC IMMUNOLOGISTS
Journal of immunology (Baltimore, Md. : 1950), 197(4), 1074-1088
Journal of immunology (Baltimore, Md. : 1950)
The Journal of Immunology

EBV is the major infectious environmental risk factor for multiple sclerosis (MS), but the underlying mechanisms remain obscure. Patient studies do not allow manipulation in vivo. We used the experimental autoimmune encephalomyelitis (EAE) models in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb8aabb29b969d758624f8bf4c4628f
https://doi.org/10.4049/jimmunol.1600124

An Overview of Models, Methods, and Reagents Developed for Translational Autoimmunity Research in the Common Marmoset (Callithrix jacchus)

Autor: S. Anwar Jagessar, Erwin L. A. Blezer, Jan Bauer, Bert A. 't Hart, Yolanda S. Kap, Michel P.M. Vierboom

Publikováno v: Experimental Animals. 62:159-171

The common marmoset (Callithrix jacchus) is a small-bodied Neotropical primate and a useful preclinical animal model for translational research into autoimmune-mediated inflammatory diseases (AIMID), such as rheumatoid arthritis (RA) and multiple scl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbb06e4e36f5234899ae06a2ffd8ccd6
https://doi.org/10.1538/expanim.62.159

Unravelling the T-cell-mediated autoimmune attack on CNS myelin in a new primate EAE model induced with MOG34-56peptide in incomplete adjuvant

Autor: S. Anwar Jagessar, Jon D. Laman, Jan W. Drijfhout, Jeroen H. Blokhuis, Jan Bauer, Bert A. 't Hart, Erwin L. A. Blezer, Peter J. van den Elsen, Jacqueline Wubben, Nicole Heijmans

Publikováno v: European Journal of Immunology. 42:217-227

Induction of experimental autoimmune encephalomyelitis (EAE) has been documented in common marmosets using peptide 34–56 from human myelin/oligodendrocyte glycoprotein (MOG34-56) in incomplete Freund's adjuvant (IFA). Here, we report that this EAE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e52a8be2dd1cbb063d30452044b4bd71
https://doi.org/10.1002/eji.201141863