Zobrazeno 1 - 10
of 57
pro vyhledávání: '"S. A. Hoare"'
Autor:
S. Herd-Hoare, C. M. Shackleton
Publikováno v:
Ecosystems and People, Vol 18, Iss 1, Pp 616-629 (2022)
Provisioning ecosystem services (PES) are typically crucial to rural livelihoods, especially in developing countries. However, the links between PES and local biodiversity or landscape heterogeneity are poorly explored. Here, we examined the extent o
Externí odkaz:
https://doaj.org/article/e2af9d526efa466fb28cc5f16313a071
Autor:
S. Herd-Hoare, Charlie M. Shackleton
Publikováno v:
Ecosystem Services. 46:101201
The contribution of ecosystem services to smallholder agriculture is widely recognised. However, they are seldom analysed in tandem with the ecosystem disservices, such as crop weeds and pests, which the same systems produce. We do so by quantifying
Autor:
W. Heung Chong, Richard Marais, David M. Kallenberg, S F Hoare, J. W. M. Chow, Dorothy C. Bennett, Rebecca S. Collinson, Carla Milagre, Lucy Hill, Julia K. Soo, Alastair D. MacKenzie Ross, W. Nicol Keith, Mehnaz Hossain
Publikováno v:
Pigment Cell & Melanoma Research. 24:490-503
Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers. H
Autor:
Claire J. Cairney, Alan Bilsland, Sharon Burns, Kyle Lafferty-Whyte, S F Hoare, William Nicol Keith, Nadia Zaffaroni
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 5, Pp 405-414 (2010)
Replicative senescence forms a major barrier to tumor progression. Cancer cells bypass this by using one of the two known telomere maintenance mechanisms: telomerase or the recombination-based alternative lengthening of telomeres (ALT) mechanism. The
Autor:
Chunbo Yang, Lyle Armstrong, Irina Neganova, Philip W. Hinds, W. Nicol Keith, Michael J. Cooke, Xin Zhang, Tom Strachan, Miodrag Stojkovic, Majlinda Lako, Owen Hughes, Stefan Przyborski, George Anyfantis, Stefan Fenyk, Stuart P. Atkinson, S F Hoare
Publikováno v:
The Journal of Cell Biology
In this study, we show that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components. Chromatin immunoprecipitation combined with reporter-b
Autor:
U. Prabhakar, R. Vora, M. Nakada, M. DeWitte, R. E. Corringham, C. Sturgeon, Duncan I. Jodrell, S. A. Hoare, Ewan Brown, John F. Smyth, David Propper, Frances R. Balkwill, Rhona Aird, Kellie A. Charles, R. L. Rye
Publikováno v:
Annals of Oncology. 19:1340-1346
Background Tumour necrosis factor-α (TNF-α) is an important regulator of the chronic inflammation contributing to tumour progression. Infliximab, an anti-TNF-α monoclonal antibody was investigated in this trial of patients with advanced cancer. Th
Publikováno v:
British Journal of Cancer
Telomere length is maintained by two known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT). The ALT pathway is more commonly activated in tumours of mesenchymal origin, although the mechanisms involved in the decisi
Publikováno v:
Day 3 Thu, October 29, 2015.
This paper provides a background on remotely operated seafloor drill technology and its benefits to the offshore industry. It also presents a bearing capacity and breakout force analysis for Fugro's Seafloor Drill I at a deepwater location. Both Seaf
Publikováno v:
Serakinci, N, Hoare, S F, Kassem, M, Atkinson, S P & Keith, W N 2006, ' Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell ', Regenerative Medicine, vol. 1, no. 1, pp. 125-131 . https://doi.org/10.2217/17460751.1.1.125
Udgivelsesdato: Jan The human adult mesenchymal stem cell (hMSC) does not express telomerase and has been shown to be the target for neoplastic transformation after transduction with hTERT. These findings lend support to the stem cell hypothesis of c
Publikováno v:
Oncogene. 25:61-69
Basal telomerase activity is dependent on expression of the hTERT and hTR genes and upregulation of telomerase gene expression is associated with tumour development. It is therefore possible that signal transduction pathways involved in tumour develo