Zobrazeno 1 - 10
of 453
pro vyhledávání: '"S. A. Hasnain"'
Autor:
Seiji Watanabe, Kangsa Amporndanai, Raheela Awais, Caroline Latham, Muhammad Awais, Paul M. O’Neill, Koji Yamanaka, S. Samar Hasnain
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) selectively affects motor neurons. SOD1 is the first causative gene to be identified for ALS and accounts for at least 20% of the familial (fALS) and up to 4% of sporadic (sALS) cases globally with some ge
Externí odkaz:
https://doaj.org/article/5cce70c881dc4718bdc19c5c4fdd5fa7
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Quinol-dependent nitric oxide reductases (qNORs) are considered members of the respiratory heme-copper oxidase superfamily, are unique to bacteria, and are commonly found in pathogenic bacteria where they play a role in combating the host im
Externí odkaz:
https://doaj.org/article/1afe9520cdcc4df4bab359b25a8721a7
Autor:
Md Amin Hossain, Richa Sarin, Daniel P Donnelly, Brandon C Miller, Alexandra Weiss, Luke McAlary, Svetlana V Antonyuk, Joseph P Salisbury, Jakal Amin, Jeremy B Conway, Samantha S Watson, Jenifer N Winters, Yu Xu, Novera Alam, Rutali R Brahme, Haneyeh Shahbazian, Durgalakshmi Sivasankar, Swathi Padmakumar, Aziza Sattarova, Aparna C Ponmudiyan, Tanvi Gawde, David E Verrill, Wensheng Yang, Sunanda Kannapadi, Leigh D Plant, Jared R Auclair, Lee Makowski, Gregory A Petsko, Dagmar Ringe, Nathalie Y R Agar, David J Greenblatt, Mary Jo Ondrechen, Yunqiu Chen, Justin J Yerbury, Roman Manetsch, S Samar Hasnain, Robert H Brown, Jeffrey N Agar
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002462 (2024)
Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that SOD1, which is normally a stable dimer, dissociates into toxic monome
Externí odkaz:
https://doaj.org/article/ae0b075acaa84b09a950667731983ac1
Autor:
S. Samar Hasnain
Publikováno v:
Journal of Synchrotron Radiation, Vol 30, Iss 1, Pp 273-275 (2023)
Externí odkaz:
https://doaj.org/article/e773efb507fe413a89f75859e20dabcf
Publikováno v:
IUCrJ, Vol 8, Iss 5, Pp 705-708 (2021)
Externí odkaz:
https://doaj.org/article/3cbf4a4035e14e3ab01454621ef706d4
Autor:
Kangsa Amporndanai, Xiaoli Meng, Weijuan Shang, Zhenmig Jin, Michael Rogers, Yao Zhao, Zihe Rao, Zhi-Jie Liu, Haitao Yang, Leike Zhang, Paul M. O’Neill, S. Samar Hasnain
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Ebselen is an organoselenium drug that inhibits the SARS-CoV-2 main protease (Mpro). Here, the authors co-crystallised Mpro with ebselen and an ebselen derivative and observed an enzyme bound organoselenium covalent adduct in the crystal structures,
Externí odkaz:
https://doaj.org/article/8cf917f0f0d94c58998c45d6d9518f5b
Autor:
Daisuke Sasaki, Tatiana F. Watanabe, Robert R. Eady, Richard C. Garratt, Svetlana V. Antonyuk, S. Samar Hasnain
Publikováno v:
IUCrJ, Vol 7, Iss 3, Pp 557-565 (2020)
Copper-containing nitrite reductases (CuNiRs) are found in all three kingdoms of life and play a major role in the denitrification branch of the global nitrogen cycle where nitrate is used in place of dioxygen as an electron acceptor in respiratory e
Externí odkaz:
https://doaj.org/article/b1d7021082c14458bbf1e939a9e3911c
Autor:
Juliana O. de Souza, Suzete M. Almeida, Guilherme E. Souza, Camila L. Zanini, Everton M. da Silva, Juliana Calit, Daniel Y. Bargieri, Kangsa Amporndanai, Svetlana Antonyuk, S. Samar Hasnain, Fabio C. Cruz, Dhelio B. Pereira, Glaucius Oliva, Arlene G. Corrêa, Anna C.C. Aguiar, Rafael V.C. Guido
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 3, Iss , Pp 100012- (2021)
4(1H)-quinolone is an attractive template for antimalarial drug discovery campaigns. Given the current global increase in drug and insecticide resistance, the discovery of new antimalarial drugs is an urgent goal for the fight against malaria. Here,
Externí odkaz:
https://doaj.org/article/b11554c5e99a45dc984cc104c0a6f405
Autor:
Thomas P. Halsted, Keitaro Yamashita, Chai C. Gopalasingam, Rajesh T. Shenoy, Kunio Hirata, Hideo Ago, Go Ueno, Matthew P. Blakeley, Robert R. Eady, Svetlana V. Antonyuk, Masaki Yamamoto, S. Samar Hasnain
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 761-772 (2019)
Copper-containing nitrite reductases (CuNiRs) that convert NO2− to NO via a CuCAT–His–Cys–CuET proton-coupled redox system are of central importance in nitrogen-based energy metabolism. These metalloenzymes, like all redox enzymes, are very s
Externí odkaz:
https://doaj.org/article/75b697a700aa49f6a796474d45d8a635
Publikováno v:
IUCrJ, Vol 6, Iss 2, Pp 167-177 (2019)
Structural biology continues to benefit from an expanding toolkit, which is helping to gain unprecedented insight into the assembly and organization of multi-protein machineries, enzyme mechanisms and ligand/inhibitor binding. The combination of resu
Externí odkaz:
https://doaj.org/article/da98243db34a4467985b9d3047825d78