A phase I study of the safety and pharmacokinetics of the histone deacetylase inhibitor belinostat administered in combination with carboplatin and/or paclitaxel in patients with solid tumours

Autor: Poul Knoblauch, Elizabeth Crowley, J.S. de Bono, J. Tjornelund, Rajesh Sinha, Laura Vidal, Richard T. Penson, Morten Dræby Sørensen, P. Buhl-Jensen, L. R. Molife, Ulrik Lassen, S-A Engelholm

Publikováno v: British Journal of Cancer

Background: This phase I study assessed the maximum tolerated dose, dose-limiting toxicity (DLT) and pharmacokinetics of belinostat with carboplatin and paclitaxel and the anti-tumour activity of the combination in solid tumours. Methods: Cohorts of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7de1324b869064e3acccbbf74ef36c6
https://doi.org/10.1038/sj.bjc.6605726

RADIATION THERAPY

Autor: M. Anwar, J. Lupo, A. Molinaro, J. Clarke, N. Butowski, M. Prados, S. Chang, D. HaasKogan, S. Nelson, J. Ashman, J. Drazkowski, R. Zimmerman, T. Lidner, C. Giannini, A. Porter, N. Patel, I. Atean, N. Shin, A. Toltz, C. Laude, C. Freeman, J. Seuntjens, D. Roberge, M. Back, M. Kastelan, L. Guo, H. Wheeler, P. Beauchesne, G. Faure, G. Noel, T. Schmitt, L. Martin, E. Jadaud, C. Carnin, J. Bowers, N. Bennion, H. Lomas, K. Spencer, M. Richardson, W. McAllister, J. Sheehan, D. Schlesinger, R. Kersh, J. Brower, S. Gans, W. Hartsell, S. Goldman, J. H.-C. Chang, N. Mohammed, M. Siddiqui, V. Gondi, E. Christensen, S. Klawikowski, A. Garg, M. McAleer, L. Rhines, J. Yang, P. Brown, E. Chang, S. Settle, A. Ghia, M. Edson, G. N. Fuller, P. Allen, J. Li, A. Garsa, S. Badiyan, J. Simpson, J. Dowling, K. Rich, M. Chicoine, E. Leuthardt, A. Kim, C. Robinson, B. Gill, D. Peskorski, R. Lalonde, M. S. Huq, J. Flickinger, A. Graff, P. Clerkin, H. Smith, R. Isaak, J. Dinh, D. Grosshans, J. de Groot, S. McGovern, M. Gilbert, A. Mahajan, T. Gupta, S. Mohanty, S. Kannan, R. Jalali, J. Hardie, N. Laack, S. Kizilbash, J. Buckner, J. Uhm, I. Parney, R. Jenkins, P. Decker, J. Voss, R. Hiramatsu, S. Kawabata, M. Furuse, S.-I. Niyatake, T. Kuroiwa, M. Suzuki, K. Ono, C. Hobbs, L. Vallow, J. Peterson, K. Jaeckle, M. Heckman, R. Bhupendra, D. Horowitz, C.-S. Wuu, W. Feng, D. Drassinower, A. Lasala, A. Lassman, T. Wang, D. Indelicato, R. Rotondo, J. Bradley, E. Sandler, P. Aldana, N. Mendenhall, R. Marcus, R. Kabarriti, W. F. Mourad, D. M. Mejia, J. Glanzman, S. Patel, R. Young, M. Bernstein, L. Hong, J. Fox, P. LaSala, S. Kalnicki, M. Garg, S. Khatua, P. Hou, J. Wolff, J. Hamilton, W. Zaky, L. Ketonen, S.-H. Kim, S. R. Lee, null Ji, Y. Oh, U. Krishna, N. Shah, R. Pathak, A. Lila, P. Menon, A. Goel, R. Lall, T. Smith, A. Schumacher, A. McCaslin, J. Kalapurakal, J. Chandler, W. Magnuson, H. I. Robins, P. Mohindra, S. Howard, D. Manfredi, C. L. Rogers, M. Palmer, E. Hillebrandt, S. Bilton, G. Robinson, K. Velasco, M. Mehta, J. McGregor, J. Grecula, M. Ammirati, C. Pelloski, L. Lu, N. Gupta, S. Bell, S. Moller, I. Law, P. M. a. Rosenschold, J. Costa, H. S. Poulsen, S. A. Engelholm, A. Morrison, B. Cuglievan, Z. Khatib, T. Santiago, D. M. Blakaj, M. Welch, J. Graber, L. X. Hong, A. Patel, A. Tandon, M. B. Bernstein, R. A. Shourbaji, M. D. Kinon, J. L. Fox, P. Lasala, M. K. Garg, S. Nicholas, R. Salvatori, M. Lim, K. Redmond, A. Quinones, G. Gallia, D. Rigamonti, L. Kleinberg, W. Mourad, R. Yaparpalvi, O. Mian, M. Degaonkar, H. Sair, S. Terezakis, T. McNutt, M. Wharam, M. Mahone, A. Horska, U. Rezvi, E. Melian, M. Surucu, I. Mescioglu, V. Prabhu, J. Clark, D. Anderson, J. Robbins, R. Yechieli, S. Ryu, M. I. Ruge, B. Suchorska, C. Hamisch, K. Mahnkopf, R. Lehrke, H. Treuer, V. Sturm, J. Voges, A. Sahgal, A. Al-Omair, L. Masucci, L. Masson-Cote, E. Atenafu, D. Letourneau, E. Yu, R. Rampersaud, S. Lewis, A. Yee, I. Thibault, M. Fehlings, W. Shi, J. Palmer, L. Kenyon, J. Glass, L. Kim, M. Werner-wasik, D. Andrews, S. Susheela, S. Revannasiddaiah, S. Muzumder, G. Mallarajapatna, A. Basavalingaiah, M. Gupta, K. Kallur, M. Hassan, R. Bilimagga, K. Tamura, M. Aoyagi, N. Ando, T. Ogishima, M. Yamamoto, K. Ohno, T. Maehara, Z. Xu, M. L. Vance, D. Blakaj, P. A. LaSala, J. J. Graber, A. L. Zimmerman, M. A. Vogelbaum, G. H. Barnett, E. S. Murphy, J. H. Suh, L. Angelov, C. A. Reddy, S. T. Chao

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b78bac3ac19827bc5cbf455c9b49d0
https://europepmc.org/articles/PMC3823902/

Three-dimensional endoluminal ultrasound-guided interstitial brachytherapy in patients with anal cancer

Autor: Bachmann M. Nielsen, Anders F. Christensen, S. A. Engelholm

Publikováno v: Acta radiologica (Stockholm, Sweden : 1987). 49(2)

Background: New techniques using image guidance other than computed tomography (CT) and traditional two-dimensional (2D) endosonography might improve interstitial brachytherapy in patients with anal cancer. Purpose: To investigate a new technique gui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6668025b99e718951493c4e7053b272
https://pubmed.ncbi.nlm.nih.gov/18300134

[Mortality of cervix cancer can be halved]

Autor: S A, Engelholm, B, Ottesen

Publikováno v: Ugeskrift for laeger. 161(33)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::801c9ca8de940e17368789ce2ef79973
https://pubmed.ncbi.nlm.nih.gov/10464467

Paclitaxel (175 mg/m2 over 3 hours) with cisplatin or carboplatin in previously untreated ovarian cancer: an interim analysis

Autor: J P, Neijt, S A, Engelholm, P O, Witteveen, M K, Tuxen, P G, Sørensen, M, Hansen, F, Hirsch, C, Sessa, C, de Swart, H C, van Houwelingen, B, Lund, S W, Hansen

Publikováno v: Seminars in oncology. 24(5 Suppl 15)

The side effects of cisplatin (75 mg/m2) in combination with paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) (175 mg/m2 over 3 hours) are expected to be more severe and frequent than those of carboplatin (area under the concentration-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a337e5ca33d80147da8ab86cf40529a
https://pubmed.ncbi.nlm.nih.gov/9346220