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Cloning and Expression of Rat Prostaglandin Endoperoxide Synthase (Cyclooxygenase)-2 cDNA

Autor: S. A. Culp, Wanda Cromlish, Chi-Chung Chan, Brian P. Kennedy

Publikováno v: Biochemical and Biophysical Research Communications. 197:494-500

Rat prostaglandin endoperoxidase synthase-2 (PGHS-2) cDNA was cloned from rat calvarial osteoblasts total RNA by RT-PCR. The primary sequence of rat PGHS-2 had 98% and 92% identity to the mouse and human enzymes, respectively. Transfection of the rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a591afbc5dc5258491b9dcf2899acf35
https://doi.org/10.1006/bbrc.1993.2506

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Replication of acetylaminofluorene-adducted plasmids in human cells: spectrum of base substitutions and evidence of excision repair

Autor: J. Justin McCormick, S J Culp, J Boldt, M. C.-M. Mah, Veronica M. Maher

Publikováno v: Proceedings of the National Academy of Sciences. 88:10193-10197

In rats fed the liver carcinogen 2-acetylaminofluorene (AAF), the two most abundant types of DNA adduct are N-(deoxyguanosin-8-yl)-2-acetylaminofluorene and its deacetylated derivative. When plasmids carrying AAF adducts replicate in bacteria, the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a3f86339a1612d4aa87f117c2a876f
https://doi.org/10.1073/pnas.88.22.10193

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Photoreaction, phototoxicity, and photocarcinogenicity of retinoids

Autor: Qingsu Xia, S. J. Culp, P. P. Fu, William H. Tolleson, S.-H. Cheng, L. Coop, P. C. Howard, Wayne G. Wamer

Publikováno v: Journal of environmental science and health. Part C, Environmental carcinogenesisecotoxicology reviews. 21(2)

Sunlight is a human carcinogen. Many retinoid-containing cosmetics are used to protect damages caused by sunlight irradiation. Since retinol is thermally unstable and retinyl palmitate (RP) s relatively more stable, RP is also widely used as an ingre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb51338636dd87ec544ca71245b375ea
https://pubmed.ncbi.nlm.nih.gov/15845224

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DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene

Autor: S J, Culp, A R, Warbritton, B A, Smith, E E, Li, F A, Beland

Publikováno v: Carcinogenesis. 21(7)

Coal tar is a complex mixture containing hundreds of compounds, at least 30 of which are polycyclic aromatic hydrocarbons, including the carcinogen benzo[a]pyrene (BaP). Although humans are exposed to complex mixtures on a daily basis, the synergisti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06cdd46cb8abdc55338c773642777dfa
https://pubmed.ncbi.nlm.nih.gov/10874023

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Selective Inhibitors of Cox-2

Autor: G. P. O’neill, B. P. Kennedy, J. A. Mancini, S. Kargman, M. Ouellet, J. Yergey, J.-P. Falgueyret, W. A. Cromlish, P. Payette, C.-C. Chan, S. A. Culp, C. Vincent, C. Boily, M. Abramovitz, J. F. Evans, A. W. Ford-Hutchinson, P. J. Vickers, M. D. Percival

Publikováno v: Novel Molecular Approaches to Anti-Inflammatory Therapy ISBN: 9783034872782

The main target of non-steroidal anti-inflammatory drugs (NSAIDs) is prostaglandin G/H synthase (PGHS), also known as cyclooxygenase (COX), which exists as two isoforms. In order to evaluate the contributions of PGHS isoforms to physiological and pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08a561faab377b4e0222a8bf132d0d0b
https://doi.org/10.1007/978-3-0348-7276-8_16

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High-level expression of active human cyclooxygenase-2 in insect cells

Autor: Paul Payette, S. A. Culp, Wanda Cromlish, M.D. Percival, Marc Ouellet, Brian P. Kennedy

Publikováno v: Archives of biochemistry and biophysics. 314(1)

Active human cyclooxygenase-2 (Cox-2) was expressed at high levels in insect cells using a recombinant baculovirus. The specific activity of Cox-2 in the microsomes of infected cells was 0.51 mumol O2/min/mg and was comparable to that obtained for pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0447d0505e49ab18e494f8f8ffde569c
https://pubmed.ncbi.nlm.nih.gov/7944394

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[3H]DuP 734 [1-(cyclopropylmethyl)-4-(2'-(4'-fluorophenyl)-2'- oxoethyl)-piperidine HBr]: a receptor binding profile of a high-affinity novel sigma receptor ligand in guinea pig brain

Autor: S G, Culp, D, Rominger, S W, Tam, E B, De Souza

Publikováno v: The Journal of pharmacology and experimental therapeutics. 263(3)

The in vitro binding properties of 1-(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'-oxoethyl)pipe ridi ne HBr, [3H]DuP 734, a novel sigma receptor ligand, were examined in homogenates of guinea pig brain. Specific [3H]DuP 734 binding (10 microM halo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a3653d2dda477f521e7a0ace8cec2c4
https://pubmed.ncbi.nlm.nih.gov/1361573

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Gene transfer into coronary arteries of intact animals with a percutaneous balloon catheter

Autor: Roger Gammon, J S Desper, Robert P. Bauman, Judith L. Swain, S. C. Culp, Chang S. Lim, Richard S. Stack, Gregory D. Chapman

Publikováno v: Circulation research. 71(1)

Genetic manipulation of the vasculature may offer insights into the pathogenesis of coronary artery disease and may lead to gene therapy for disorders such as restenosis after percutaneous coronary angioplasty. The goal of this study was to develop a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddf9be290f7a513043411c2f9a576c4
https://pubmed.ncbi.nlm.nih.gov/1606665

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