Zobrazeno 1 - 10
of 232
pro vyhledávání: '"S. A. Andronati"'
Publikováno v:
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 24, Iss 4(72), Pp 45-51 (2019)
It is known that 1,4-benzodiazepines have neurotropic properties. Relatively recently, we have shown that 2-arylidenesubstituted 1,4-benzodiazepines demonstrate pronounced analgesic properties. In this regard, the aim of this work is the synthesis of
Externí odkaz:
https://doaj.org/article/b9ba9e505d2448e78fabfda43441dc86
Autor:
E. A. Lukianova, L. N. Ognichenko, T. A. Yurpalova, N. A. Burenkova, S. P. Smulsky, V. I. Pavlovsky, S. A. Andronati, V. E. Kuz`min
Publikováno v:
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 23, Iss 1(65), Pp 48-57 (2018)
QSAR analysis of the structural infl uence of 3-substituted 1,2-dihydro-3Н-1,4-benzodiazepine derivatives on the thermodynamic characteristics (ΔН0, ΔS0 and ΔG0) of their complexation with compounds was the main problem of QSAR analysis in this
Externí odkaz:
https://doaj.org/article/d05149a9894f4168bb63935ce69c78ca
Publikováno v:
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 22, Iss 4(64), Pp 29-36 (2017)
The 2-amino-3H-quinazolin-4-one scaffold is found in a large number of molecules with physiological significance and pharmaceutical utility. Previously we synthesized a series of potent antagonists of fibrinogen receptor, derivatives of 2-(piperazin-
Externí odkaz:
https://doaj.org/article/33ae4f4c3be44807af017a3fcab4c233
Autor:
P. A. Virych, O. V. Shelyuk, T. A. Kabanova, O. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati
Publikováno v:
Regulatory Mechanisms in Biosystems, Vol 8, Iss 2, Pp 224-230 (2017)
The development of modern organic chemistry and molecular modeling technologies simplify the search for potential inhibitors of various receptor systems and biological processes. The one of the directions is the development of analgesics of broad spe
Externí odkaz:
https://doaj.org/article/6a1c3ef2dac84b43b041afe2947dedea
Autor:
P. A. Virych, O. V. Shelyuk, T. A. Kabanova, E. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati
Publikováno v:
The Ukrainian Biochemical Journal, Vol 89, Iss 1, Pp 31-37 (2017)
Biochemical properties of 3-substituted 1,4-benzodiazepine determined by the characteristics of their chemical structure. Influence of 3-substituted 1,4-benzodiazepin-2-ones on maximal normalized rate and amplitudes of isometric smooth muscle contrac
Externí odkaz:
https://doaj.org/article/8617cedaee4940c8ace92184ef49d726
Autor:
P. A. Virych, O. V. Shelyuk, T. A. Kabanova, O. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati
Publikováno v:
Regulatory Mechanisms in Biosystems, Vol 8, Iss 1, Pp 30-35 (2017)
Damage to tissue, inflammation and disruption of normal functioning of organs are often accompanied by pain. In pain perceptions, the kinin-kallikrein system with bradykinin as mediator is very important. Regulatory activity of the kinin-kallikrein s
Externí odkaz:
https://doaj.org/article/a80f4e671fd44c01b9e903583416e0e7
Autor:
S. A. Andronati, E. A. Shesterenko, O. V. Sevastyanov, I. I. Romanovskaya, E. A. Semenishina, V. I. Pavlovsky
Publikováno v:
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 13, Iss 11, Pp 37-45 (2016)
Вивчений гідроліз естерів 1,4-бенздіазепін-2-ону: 3-метилкарбонілокси-, 3-пе-нтилкарбонілокси-, З-гексилкарбонілокси- і 3-гептилкарбонілокс
Externí odkaz:
https://doaj.org/article/daae0611d02f4b2eb861391cd2b2e92e
Publikováno v:
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 13, Iss 12, Pp 73-78 (2016)
Cинтeзoвaнo новий оптично aктивний RGDF міметик — 4-(1,2,3,4-тeтpaгiдpoiзoxiнoлiн-7-iл)aмiнo-4-oкcoбyтиpил-D-ß-фeнiл-ß-aлaнiн. Bcтaнoвлeнo, що синтезoвaний пептидомі
Externí odkaz:
https://doaj.org/article/535d166717a04f34840145f2b3e7893e
Autor:
E. A. Semenishyna, V. I. Pavlovsky, S. A. Andronati, Yu. A. Simonov, I. G. Philippova, A. I. Sivko, I. A. Kravchenko, G. V. Malcev, M. Gdaniec, A. V. Mazepa
Publikováno v:
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 14, Iss 3, Pp 44-56 (2016)
3-Acyloxy-7-bromo-5-(2’-chloro)phenyl-1,2-dihydro-3.H-1,4-benzodiazepin-2-ones (2-8) were synthesized by the interaction of the 7-bromo-3-hydroxy-5-(2’-chloro)phenyl-1,2-dihydro-3.H-1,4-benzodiazepin-2-one (1) with chloroanhy-drides of correspond
Externí odkaz:
https://doaj.org/article/9825c1263cd3478984b792deaa70bb93
Publikováno v:
Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 15, Iss 2, Pp 60-68 (2015)
Ethyl ethers of N-[4-(isoindoline-5-yl)amino-4-oxobutyryl]-D,L-β-substituted-β-alanines were synthesized. Estimation of antiaggregatory activity of the compounds obtained has showed that the compounds possess an oral activity ex vivoin mice with th
Externí odkaz:
https://doaj.org/article/12332a27fd4942da8ea1ab480da25381