Zobrazeno 1 - 10
of 1 331
pro vyhledávání: '"S. BANU"'
Previous studies of the flexibilities of ancestral proteins suggests that proteins evolve their function by altering their native state ensemble. Here we propose a more direct method of visualizing this by measuring the changes in the vibrational den
Externí odkaz:
http://arxiv.org/abs/2109.07004
Publikováno v:
Phys. Rev. Research 2, 023367 (2020)
Naively, one expects the information communicated by an enzyme downstream within a signaling network, in which the enzyme is embedded, to grow monotonically with the enzyme's rate of product formation. However, here we observe that this does not nece
Externí odkaz:
http://arxiv.org/abs/1907.13238
Publikováno v:
In Biophysical Journal 25 July 2023 122(14):2938-2947
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Open House International, 2021, Vol. 46, Issue 4, pp. 636-650.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/OHI-02-2021-0053
Autor:
I Can Kazan, Prerna Sharma, Mohammad Imtiazur Rahman, Andrey Bobkov, Raimund Fromme, Giovanna Ghirlanda, S Banu Ozkan
Publikováno v:
eLife, Vol 11 (2022)
We develop integrated co-evolution and dynamic coupling (ICDC) approach to identify, mutate, and assess distal sites to modulate function. We validate the approach first by analyzing the existing mutational fitness data of TEM-1 β-lactamase and show
Externí odkaz:
https://doaj.org/article/10f06b29d61c4ec18c13b76110549cdb
Publikováno v:
Clinical and Experimental Obstetrics & Gynecology, Vol 48, Iss 5, Pp 1071-1074 (2021)
Background: Polyhydramnios is a common cause of adverse pregnancy outcomes. The prediction of polyhydramnios in early pregnancy may lead to improved treatments and will diminish these adverse outcomes. Objective: This study aims to investigate the ro
Externí odkaz:
https://doaj.org/article/735dee3d1e844b0d95dbac2f27ff0e6f
Autor:
Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
TEM-1 β-lactamase evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency and degrades β-lactam antibiotics with a strong preference for penicillins. Here authors developed a computational approach t
Externí odkaz:
https://doaj.org/article/9f68b130500b474887f6a03663bb2f12
Publikováno v:
İşletme Araştırmaları Dergisi / Journal of Business Research. 12(4):4205-4219
Externí odkaz:
https://www.ceeol.com/search/article-detail?id=969536
Autor:
Nicholas J Ose, Brandon M Butler, Avishek Kumar, I Can Kazan, Maxwell Sanderford, Sudhir Kumar, S Banu Ozkan
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1010006 (2022)
Many pathogenic missense mutations are found in protein positions that are neither well-conserved nor fall in any known functional domains. Consequently, we lack any mechanistic underpinning of dysfunction caused by such mutations. We explored the di
Externí odkaz:
https://doaj.org/article/6e2ba546c14d47ba9f054f2d9606ca48