Zobrazeno 1 - 10 of 923 pro vyhledávání: '"S.‐L. Cheng"'
1
Akademický článek
Integrative analysis reveals associations between oral microbiota dysbiosis and host genetic and epigenetic aberrations in oral cavity squamous cell carcinoma
Autor: Liuyang Cai, Hengyan Zhu, Qianqian Mou, Po Yee Wong, Linlin Lan, Cherrie W. K. Ng, Pu Lei, Man Kit Cheung, Daijuanru Wang, Eddy W. Y. Wong, Eric H. L. Lau, Zenon W. C. Yeung, Ronald Lai, Katie Meehan, Sherwood Fung, Kwan Chee A. Chan, Vivian W. Y. Lui, Alfred S. L. Cheng, Jun Yu, Paul K. S. Chan, Jason Y. K. Chan, Zigui Chen
Publikováno v: npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Dysbiosis of the human oral microbiota has been reported to be associated with oral cavity squamous cell carcinoma (OSCC) while the host-microbiota interactions with respect to the potential impact of pathogenic bacteria on host genomic and
Externí odkaz: https://doaj.org/article/6d1d6f4104b84fe4850c86de36df8238
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2
Akademický článek
The molecular classification of cancer‐associated fibroblasts on a pan‐cancer single‐cell transcriptional atlas
Autor: Bonan Chen, Wai Nok Chan, Fuda Xie, Chun Wai Mui, Xiaoli Liu, Alvin H. K. Cheung, Raymond W. M. Lung, Chit Chow, Zhenhua Zhang, Canbin Fang, Peiyao Yu, Shihua Shi, Shikun Zhou, Guoming Chen, Zhangding Wang, Shouyu Wang, Xiaofan Ding, Bing Huang, Li Liang, Yujuan Dong, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Nathalie Wong, Jun Yu, Kwok Wai Lo, Gary M. K. Tse, Wei Kang, Ka Fai To
Publikováno v: Clinical and Translational Medicine, Vol 13, Iss 12, Pp n/a-n/a (2023)
Abstract Background Cancer‐associated fibroblasts (CAFs), integral to the tumour microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic or anti‐tumourigenic functions. Their inherent phenotypic and functional di
Externí odkaz: https://doaj.org/article/9cd923a1d35b477fa1d0c64190bf7e15
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3
Akademický článek
Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models
Autor: Stanley K. K. Cheung, Jacinda Kwok, Penelope M. Y. Or, Chi Wai Wong, Bo Feng, Kwong Wai Choy, Raymond C. C. Chang, J. Peter H. Burbach, Alfred S. L. Cheng, Andrew M. Chan
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract PTEN hamartoma tumour syndrome is characterised by mutations in the human PTEN gene. We performed transcriptomic and proteomic analyses of neural tissues and primary cultures from heterozygous and homozygous Pten-knockout mice. The somatosen
Externí odkaz: https://doaj.org/article/fd7b9f61c0644cdfa99aa303d784c7ff
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5
Akademický článek
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
Autor: Yuan Tian, Bin Yang, Weinan Qiu, Yajing Hao, Zhenxing Zhang, Bo Yang, Nan Li, Shuqun Cheng, Zhangjun Lin, Yao-cheng Rui, Otto K. W. Cheung, Weiqin Yang, William K. K. Wu, Yue-Sun Cheung, Paul B. S. Lai, Jianjun Luo, Joseph J. Y. Sung, Runsheng Chen, Hong-Yang Wang, Alfred S. L. Cheng, Pengyuan Yang
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Non alcoholic fatty liver disease (NAFLD) associates with an elevated risk of developing hepatocellular carcinoma (HCC). Here, the authors find that Nogo-B, an endoplasmic reticulum resident protein, is upregulated by lipid uptake and acts as an onco
Externí odkaz: https://doaj.org/article/a8d1c1e18c374e28bc9f4c1c7dd4b98d
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6
Akademický článek
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
Autor: Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T. S. Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W. H. Chan, Joanna H. Tong, Yue-Sun Cheung, Paul B. S. Lai, Hector K. S. Wang, Shun-Wa Tsang, King-Lau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, Ka-Fai To, Joseph J. Y. Sung, Grace L. H. Wong, Vincent W. S. Wong, Alfred S. L. Cheng
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC path
Externí odkaz: https://doaj.org/article/6dd5d597aab145d5bf368e0227da0aaf
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7
Akademický článek
The physiological role of Motin family and its dysregulation in tumorigenesis
Autor: Tingting Huang, Yuhang Zhou, Jinglin Zhang, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Publikováno v: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018)
Abstract Members in Motin family, or Angiomotins (AMOTs), are adaptor proteins that localize in the membranous, cytoplasmic or nuclear fraction in a cell context-dependent manner. They control the bioprocesses such as migration, tight junction format
Externí odkaz: https://doaj.org/article/994ffc1ce2674fb5868526de74e68ca0
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8
Akademický článek
IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis
Autor: Yuhang Zhou, Tingting Huang, Ho Lam Siu, Chi Chun Wong, Yujuan Dong, Feng Wu, Bin Zhang, William K. K. Wu, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Publikováno v: Molecular Cancer, Vol 16, Iss 1, Pp 1-14 (2017)
Abstract Background Gastric cancer (GC) is one of the frequent causes of cancer-related death in eastern Asian population. IGF2BP2 lists in the top rank up-regulated genes in GC, but its functional role is unclear. Method The expression of IGF2BP3 in
Externí odkaz: https://doaj.org/article/dcf7843bdfdf41f6af7ad31756057e57
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