Zobrazeno 1 - 10
of 543
pro vyhledávání: '"S., Thom"'
Publikováno v:
Frontiers in Education, Vol 9 (2024)
Projective geometry is a prominent area in many fields including art, design, architecture, and mathematics, but how it can contribute to children’s spatial reasoning as well as a supplementary geometry to that of Euclid’s in school mathematics c
Externí odkaz:
https://doaj.org/article/6b71867517e1420cb334d0476c43c3a2
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0309608 (2024)
Genome wide association studies (GWAS) have associated thousands of loci with quantitative human blood trait variation. Loci and related genes that impact blood trait variation may regulate blood cell-intrinsic biological processes, or alternatively
Externí odkaz:
https://doaj.org/article/5c08c42ba19e4ab4949a6f3da0cb8dc7
Autor:
Daniel Hui, Eric Sanford, Kimberly Lorenz, Scott M Damrauer, Themistocles L Assimes, Christopher S Thom, Benjamin F Voight
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0298786 (2024)
An inverse correlation between stature and risk of coronary artery disease (CAD) has been observed in several epidemiologic studies, and recent Mendelian randomization (MR) experiments have suggested causal association. However, the extent to which t
Externí odkaz:
https://doaj.org/article/4c820088beb54a40ba027cdde983d34e
Autor:
Madison B. Wilken, Jean Ann Maguire, Lea V. Dungan, Alyssa Gagne, Catherine Osorio-Quintero, Elisa A Waxman, Stella T. Chou, Paul Gadue, Deborah L. French, Christopher S. Thom
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103161- (2023)
The CHOPWT17_TPM1KOc28 iPSC line was generated to interrogate the functions of Tropomyosin 1 (TPM1) in primary human cell development. This line was reprogrammed from a previously published wild type control iPSC line.
Externí odkaz:
https://doaj.org/article/e8645c9d5bba40dc98d876e215e79737
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background The majority of Genome Wide Associate Study (GWAS) loci fall in the non-coding genome, making causal variants difficult to identify and study. We hypothesized that the regulatory features underlying causal variants are biologicall
Externí odkaz:
https://doaj.org/article/f4a22e728c53438792268211d1c8e9f8
Publikováno v:
Platelets, Vol 33, Iss 5, Pp 787-789 (2022)
Pediatric extreme thrombocytosis (EXT, platelet count > 1000 x 103/µL) is rare. In a single center retrospective analysis of hospitalized children with EXT, infants with congenital diaphragmatic hernia (CDH) were overrepresented. In general pediatri
Externí odkaz:
https://doaj.org/article/09aa0b99586b45d79d83804ca1fd4ac7
Autor:
Jennifer S. Thom
To understand a living system, such as a tree, in an ecologically systemic way involves more than simply reducing the tree down to its parts or by analyzing the tree from part to whole. Not only does one need to study the tree's leaves, stems, branch
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract Background Genetic associations link hematopoietic traits and disease end-points, but most causal variants and genes underlying these relationships are unknown. Here, we used genetic colocalization to nominate loci and genes related to share
Externí odkaz:
https://doaj.org/article/b87a2c9496794d06864d85ce1161cf72
Publikováno v:
eLife, Vol 11 (2022)
Body mass index (BMI), hyperlipidemia, and truncal adipose distribution concordantly elevate cardiovascular disease risks, but have unknown genetic effects on blood trait variation. Using Mendelian randomization, we define unexpectedly opposing roles
Externí odkaz:
https://doaj.org/article/6b317144bff24069ad946a66ee748970