Výsledky vyhledávání - "S., ATHANASOPOULOS"

Akademický článek

PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation

Autor: Lucia Iannotta, Marco Emanuele, Giulia Favetta, Giulia Tombesi, Laurine Vandewynckel, Antonio Jesús Lara Ordóñez, Jean-Michel Saliou, Matthieu Drouyer, William Sibran, Laura Civiero, R. Jeremy Nichols, Panagiotis S. Athanasopoulos, Arjan Kortholt, Marie-Christine Chartier-Harlin, Elisa Greggio, Jean-Marc Taymans

Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson’s disease (PD) and previous work suggests that dephosphorylation of LRRK2 at a cluster of heterologous phosphosites is associated to disease. W

Externí odkaz: https://doaj.org/article/5c7b59f9a8734bce82374910d2ad476b

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Akademický článek

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

Autor: Antoine Marchand, Alessia Sarchione, Panagiotis S. Athanasopoulos, Hélène Bauderlique-Le Roy, Liesel Goveas, Romain Magnez, Matthieu Drouyer, Marco Emanuele, Franz Y. Ho, Maxime Liberelle, Patricia Melnyk, Nicolas Lebègue, Xavier Thuru, R. Jeremy Nichols, Elisa Greggio, Arjan Kortholt, Thierry Galli, Marie-Christine Chartier-Harlin, Jean-Marc Taymans

Publikováno v: Cells, Vol 11, Iss 6, p 1018 (2022)

The Leucine Rich Repeat Kinase 2 (LRRK2) gene is a major genetic determinant of Parkinson’s disease (PD), encoding a homonymous multi-domain protein with two catalytic activities, GTPase and Kinase, involved in intracellular signaling and trafficki

Externí odkaz: https://doaj.org/article/18bf45a023c0403281af9f78d80acdf0

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Akademický článek

A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

Autor: Egon Deyaert, Lina Wauters, Giambattista Guaitoli, Albert Konijnenberg, Margaux Leemans, Susanne Terheyden, Arsen Petrovic, Rodrigo Gallardo, Laura M. Nederveen-Schippers, Panagiotis S. Athanasopoulos, Henderikus Pots, Peter J. M. Van Haastert, Frank Sobott, Christian Johannes Gloeckner, Rouslan Efremov, Arjan Kortholt, Wim Versées

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

The Parkinson’s disease‐associated LRRK2 protein is a multidomain Roco protein with GTPase activity. Here the authors use a multidisciplinary approach to characterize the GTPase mechanism of a homologous bacterial Roco protein and give mechanisti

Externí odkaz: https://doaj.org/article/c26addf391a34197a5007b5002985a38

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Akademický článek

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Protective effect of N-acetyl cysteine on vascular function of young individuals after a bout of resistance exercise: a randomized placebo-controlled study

Autor: G Mavraganis, G Georgiopoulos, A Sakelliou, D Delialis, R Patras, A Sianis, A M Dimopoulou, E Oikonomou, S Athanasopoulos, I Kanakakis, I Fatouros, A Mitrakou, K Stamatelopoulos

Publikováno v: European Heart Journal. 43

Background High intensity resistance exercise may temporarily induce vascular dysfunction mediated by pro-oxidant and pro-inflammatory pathways. Whether antioxidant supplements ameliorate this dysfunction has not been clarified. Purpose In the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11558796b1f28c652b04ef3ce0e2e7fd
https://doi.org/10.1093/eurheartj/ehac544.2450

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Akademický článek

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Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides

Autor: Leah G. Helton, Panagiotis S Athanasopoulos, Bernd K Gilsbach, Scotty Hall, Ranjan Kumar Singh, Ahmed Soliman, Hardy J. Rideout, Felix von Zweydorf, Christian Johannes Gloeckner, Francesco Raimondi, Franz Y. Ho, Eileen J. Kennedy, Arjan Kortholt, Jascha Tobias Manschwetus, Timothy J LeClair, Friedrich W. Herberg, Wim Versées, Michalis Kentros

Publikováno v: ACS chemical biology 16(11), 2326-2338 (2021). doi:10.1021/acschembio.1c00487
ACS chemical biology, 16(11). AMER CHEMICAL SOC

Leucine-Rich Repeat Kinase 2 (LRRK2) is a large, multidomain protein with dual kinase and GTPase function that is commonly mutated in both familial and idiopathic Parkinson's Disease (PD). While dimerization of LRRK2 is commonly detected in PD models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37fc033b725a6992a27c05c3fcd9f95
https://doi.org/10.1021/acschembio.1c00487

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CoBiToM project - I. Contact binaries towards merging

Autor: Gazeas, K.D. Loukaidou, G.A. Niarchos, P.G. Palafouta, S. Athanasopoulos, D. Liakos, A. Zola, S. Essam, A. Hakala, P.

Binary and multiple stellar systems are numerous in our solar neighbourhood with 80 per cent of the solar-type stars being members of systems with high order multiplicity. The Contact Binaries Towards Merging (CoBiToM) Project is a programme that foc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::2568eba17ff19fd2d975936157c2ffd7
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3068551

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