Microcirculation dysfunction in endotoxic shock rabbits is associated with impaired S-nitrosohemoglobin-mediated nitric oxide release from red blood cells: a preliminary study

Autor: Bo Yao, Da-Wei Liu, Wen-Zhao Chai, Xiao-Ting Wang, Hong-Min Zhang

Publikováno v: Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-9 (2019)

Abstract Background Microcirculation dysfunction with blood flow heterogeneity is an important characteristic in sepsis shock. We hypothesized that impaired ability of red blood cells to release nitric oxide resulted in microcirculation dysfunction i

Externí odkaz: https://doaj.org/article/395a67932533469a9bc4adca8adc57ad

Hemoglobin βCys93 is essential for cardiovascular function and integrated response to hypoxia

Autor: Zhang, Rongli, Hess, Douglas T., Qian, Zhaoxia, Hausladen, Alfred, Fonseca, Fabio, Chaube, Ruchi, Reynolds, James D., Stamler, Jonathan S.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2015 May . 112(20), 6425-6430.

Externí odkaz: https://www.jstor.org/stable/26462832

Protein disulfide isomerase may facilitate the efflux of nitrite derived S-nitrosothiols from red blood cells

Autor: Vasantha Madhuri Kallakunta, Anny Slama-Schwok, Bulent Mutus

Publikováno v: Redox Biology, Vol 1, Iss 1, Pp 373-380 (2013)

Protein disulfide isomerase (PDI) is an abundant protein primarily found in the endoplasmic reticulum and also secreted into the blood by a variety of vascular cells. The evidence obtained here, suggests that PDI could directly participate in the eff

Externí odkaz: https://doaj.org/article/51efa67a6f8046a88f35080cec1bf853

A Novel Possible Role for Met Hemoglobin as Carrier of Hydrogen Sulfide in the Blood

Autor: Angela Fago, Birgitte Geert Jensen

Publikováno v: Jensen, B & Fago, A 2020, ' A Novel Possible Role for Met Hemoglobin as Carrier of Hydrogen Sulfide in the Blood ', Antioxidants & Redox Signaling, vol. 32, no. 4, pp. 258-265 . https://doi.org/10.1089/ars.2019.7877

Significance: Along with other gasotransmitters nitric oxide (NO) and carbon monoxide, hydrogen sulfide (H2S) has recently emerged as an important signaling molecule with a particularly complex metabolism. Endogenous H2S reacts with multiple cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34825167e38607afeddd978582a0e8d6
https://doi.org/10.1089/ars.2019.7877

An S-Nitrosothiol (SNO) Synthase Function of Hemoglobin That Utilizes Nitrite as a Substrate

Autor: Angelo, Michael, Singel, David J., Stamler, Jonathan S.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2006 May . 103(22), 8366-8371.

Externí odkaz: https://www.jstor.org/stable/30049248