Zobrazeno 1 - 10
of 23
pro vyhledávání: '"S Y Amy Cheung"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Oncology drug discovery and development has always been an area facing many challenges. Phase 1 oncology studies are typically small, open-label, sequential studies enrolling a small sample of adult patients (i.e., 3-6 patients/cohort) in dose escala
Externí odkaz:
https://doaj.org/article/a33f9e0c7f654f328f3461dab95da55b
Autor:
Jinxin Zhao, Xiao Zhu, Songwen Tan, Chuanpin Chen, Amal Kaddoumi, Xiu-Li Guo, Yu-Wei Lin, S. Y. Amy Cheung
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/b239b3f23b9a449db7f94255aa1e9517
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1092-1106 (2021)
Abstract Pharmacometric models can enhance clinical decision making, with covariates exposing potential contributions to variability of subpopulation characteristics, for example, demographics or disease status. Intuitive visualization of models with
Externí odkaz:
https://doaj.org/article/c21fd9582c8f4d6bb77d5556f2d45d1d
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
In a rapidly growing and aging population, heart failure (HF) has become recognised as a public health concern that imposes high economic and societal costs worldwide. HF management stems from the use of highly cost-effective angiotensin converting e
Externí odkaz:
https://doaj.org/article/42b3e538736c42118b1e80d34dace342
Autor:
Soumya P. Kania, Juliana M. F. Silva, Oscar J. Charles, John Booth, S. Y. Amy Cheung, James W. T. Yates, Austen Worth, Judith Breuer, Nigel Klein, Persis J. Amrolia, Paul Veys, Joseph F. Standing
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Epstein-Barr virus (EBV) establishes a lifelong latent infection in healthy humans, kept under immune control by cytotoxic T cells (CTLs). Following paediatric haematopoetic stem cell transplantation (HSCT), a loss of immune surveillance leads to opp
Externí odkaz:
https://doaj.org/article/3ef49753c2d3482aac57ff4f625d570d
Autor:
Lourdes Cucurull‐Sanchez, Michael J. Chappell, Vijayalakshmi Chelliah, S. Y. Amy Cheung, Gianne Derks, Mark Penney, Alex Phipps, Rahuman S. Malik‐Sheriff, Jon Timmis, Marcus J. Tindall, Piet H. van derGraaf, Paolo Vicini, James W. T. Yates
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 259-272 (2019)
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermin
Externí odkaz:
https://doaj.org/article/293fdfa59097477883b9efaa13afb99e
Autor:
Zuzanna Angehrn, Liina Haldna, Anthe S. Zandvliet, Eva Gil Berglund, Joost Zeeuw, Billy Amzal, S. Y. Amy Cheung, Thomas M. Polasek, Marc Pfister, Thomas Kerbusch, Niedre M. Heckman
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
IntroductionThe increasing availability of healthcare data and rapid development of big data analytic methods has opened new avenues for use of Artificial Intelligence (AI)- and Machine Learning (ML)-based technology in medical practice. However, app
Externí odkaz:
https://doaj.org/article/fe965e9d158d4fb2b56dc40b4bf3f94b
Autor:
Bernard Sebastien, S. Y. Amy Cheung, Solange Corriol-Rohou, Margaret Gamalo-Siebers, Rana Jreich, Rajesh Krishna, Jing Liu
Publikováno v:
Journal of biopharmaceutical statistics.
The use of Bayesian methodology to design and analyze pediatric efficacy trials is one of the possible options to reduce their sample size. This reduction of the sample size results from the use of an informative prior for the parameters of interest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597ccf6ce99a8ebe471c628c10caf731
https://pubmed.ncbi.nlm.nih.gov/36524777
https://pubmed.ncbi.nlm.nih.gov/36524777
Autor:
Veronika Voronova, Corina Dota, S. Y. Amy Cheung, Gaia Schiavon, Joanna Parkinson, Brijesh Maroj, Philip Delff, Marie Cullberg, Dinko Rekić
Publikováno v:
British Journal of Clinical Pharmacology. 88:858-864
Pharmacokinetics-matched digital electrocardiogram data (n = 503 measurements from 180 patients) collected in a first-in-human, multi-part, dose-escalation (from 80 to 800 mg) and dose expansion (at 480 mg) phase 1 study in patients with advanced sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e215f8b5d116e504290ffedef3efbde9
https://doi.org/10.1111/bcp.15006
https://doi.org/10.1111/bcp.15006
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Pharmacometric models can enhance clinical decision making, with covariates exposing potential contributions to variability of subpopulation characteristics, for example, demographics or disease status. Intuitive visualization of models with multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e381a9e21bdc106caee5a83829646a9
https://pubmed.ncbi.nlm.nih.gov/34242494
https://pubmed.ncbi.nlm.nih.gov/34242494