Zobrazeno 1 - 10
of 85
pro vyhledávání: '"S Y, Tam"'
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Entamoeba histolytica is the cause of amoebiasis. The trophozoite (amoeba) form of this parasite is capable of invading the intestine and can disseminate through the bloodstream to other organs. The mechanisms that allow amoebae to evade com
Externí odkaz:
https://doaj.org/article/a0341ab335544a08ba7b3276234594f9
Autor:
Akhila Bettadapur, Samuel S Hunter, Rene L Suleiman, Maura C Ruyechan, Wesley Huang, Charles G Barbieri, Hannah W Miller, Tammie S Y Tam, Matthew L Settles, Katherine S Ralston
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010088 (2021)
While Entamoeba histolytica remains a globally important pathogen, it is dramatically understudied. The tractability of E. histolytica has historically been limited, which is largely due to challenging features of its genome. To enable forward geneti
Externí odkaz:
https://doaj.org/article/35506d785cd04428b109dd5265320e89
Autor:
Janine S. Y. Tam, Elise E. Crame, Aurelia S. Elz, Janet K. Coller, Anthony Wignall, Clive A. Prestidge, Joanne M. Bowen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 90:267-278
Introduction Gastrointestinal mucositis (GIM) is a side effect of high-dose irinotecan (CPT-11), causing debilitating symptoms that are often poorly managed. The role of TLR4 in the development of GIM has been clearly demonstrated. We, therefore, aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b69587261d5c5e0202d2e2179732af
https://doi.org/10.1007/s00280-022-04463-x
https://doi.org/10.1007/s00280-022-04463-x
Publikováno v:
Inflammation. 46:103-114
Activation of toll-like receptor 4 (TLR4) has been shown to be a major influence on the inflammatory signalling pathways in intestinal mucositis (IM), as demonstrated by TLR4 knock-out mice. Pharmacological TLR4 inhibition has thus been postulated as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812df298c284329f05dac6cc558f8159
https://doi.org/10.1007/s10753-022-01714-0
https://doi.org/10.1007/s10753-022-01714-0
Publikováno v:
Creativity Research Journal. 35:211-226
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af88ac0d4b89500f690d2905a70e08dd
https://doi.org/10.1080/10400419.2022.2057688
https://doi.org/10.1080/10400419.2022.2057688
Autor:
Rachel J. Gibson, Elise E. Crame, Janine S. Y. Tam, Kate R. Secombe, Janet K. Coller, Hannah R. Wardill, Joanne M. Bowen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 89:275-281
PURPOSE Irinotecan can cause high levels of diarrhea caused by toxic injury to the gastrointestinal microenvironment. Toll-like receptor 4 (TLR4) and the gut microbiome have previously been implicated in gastrointestinal toxicity and diarrhea; howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703af78b13d9a8b79aaf4083ecf41b3a
https://doi.org/10.1007/s00280-021-04382-3
https://doi.org/10.1007/s00280-021-04382-3
Publikováno v:
In Silico Pharmacology. 11
Toll-like receptor 4 (TLR4) has attracted interest due to its role in chemotherapy-induced gastrointestinal inflammation. This structural study aimed to provide in silico rational of the recognition and potential binding of TLR4 ligands IAXO-102, TAK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ab3d23c88abbbb0fe4a08be10afc2d
https://doi.org/10.1007/s40203-022-00137-x
https://doi.org/10.1007/s40203-022-00137-x
Akademický článek
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Akademický článek
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Autor:
Tammie S. Y. Tam, Hannah W. Miller, Rene L. Suleiman, Samuel S. Hunter, Wesley Huang, Maura C. Ruyechan, Akhila Bettadapur, Matthew L. Settles, Charles G. Barbieri, Katherine S. Ralston
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010088 (2021)
PLoS Pathogens
PLoS pathogens, vol 17, iss 11
PLoS Pathogens
PLoS pathogens, vol 17, iss 11
While Entamoeba histolytica remains a globally important pathogen, it is dramatically understudied. The tractability of E. histolytica has historically been limited, which is largely due to challenging features of its genome. To enable forward geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adc2262c4f898a71f6cb9ffae17ae6f
https://doaj.org/article/35506d785cd04428b109dd5265320e89
https://doaj.org/article/35506d785cd04428b109dd5265320e89