Zobrazeno 1 - 10
of 685
pro vyhledávání: '"S Wicker"'
Autor:
Derek Long, Liam Eade, Matthew P. Sullivan, Katharina Dost, Samuel M. Meier-Menches, David C. Goldstone, Christian G. Hartinger, Jörg S. Wicker, Katerina Taškova
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Mass spectrometry (MS) is an analytical technique for molecule identification that can be used for investigating protein-metal complex interactions. Once the MS data is collected, the mass spectra are usually interpreted manually to identify
Externí odkaz:
https://doaj.org/article/4b0d56182a504a0c8b7b8f6d706ad956
Autor:
Jia-Yuan Zhang, Justin P. Whalley, Julian C. Knight, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in COVID-19 patients has been extensively investigated. However, much less is known about the long-term effects of infection in patients
Externí odkaz:
https://doaj.org/article/bac1a98740f949f6be9c6f638e0ecc48
Autor:
Katharina Dost, Zac Pullar-Strecker, Liam Brydon, Kunyang Zhang, Jasmin Hafner, Patricia J. Riddle, Jörg S. Wicker
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Predicting in advance the behavior of new chemical compounds can support the design process of new products by directing the research toward the most promising candidates and ruling out others. Such predictive models can be data-d
Externí odkaz:
https://doaj.org/article/ea1fac4c3e694c90bc74732f0bf436e3
Autor:
Jia-Yuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Leila Godfrey, Jennie H. M. Yang, Marcin L. Pekalski, Jane Kennet, Frank Waldron-Lynch, Mark L. Evans, Timothy I. M. Tree, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Low-dose interleukin-2 is showing promise in the treatment of several autoimmune inflammatory diseases. Here authors map the trajectory of cellular and transcriptional changes in type 1 diabetes patients receiving an interval dosing interleukin-2 reg
Externí odkaz:
https://doaj.org/article/1cbfc186befb4c289f8694e2f8ebe72c
Autor:
Lorna B. Jarvis, Daniel B. Rainbow, Valerie Coppard, Sarah K. Howlett, Zoya Georgieva, Jessica L. Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T. Grist, Alasdair J. Coles, Hani S. Mousa, Stefano Pluchino, Krishnaa T. Mahbubani, Julian L. Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S. Wicker, Joanne L. Jones
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, ena
Externí odkaz:
https://doaj.org/article/45140660645e4b33867eb3d5efef93f6
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract The prediction of metabolism and biotransformation pathways of xenobiotics is a highly desired tool in environmental sciences, drug discovery, and (eco)toxicology. Several systems predict single transformation steps or complete pathways as s
Externí odkaz:
https://doaj.org/article/2c3d76fd841945f9a20a869728010aa6
Autor:
Dominik Trzupek, Fiona Hamey, Mercede Lee, John A. Todd, Linda S. Wicker, Ricardo C. Ferreira
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
Background: The characterisation of the peripheral immune system in the autoimmune disease systemic lupus erythematosus (SLE) at the single-cell level has been limited by the reduced sensitivity of current whole-transcriptomic technologies. Here we e
Externí odkaz:
https://doaj.org/article/29511b154d4649cf9a3cca4542ee9c1f
Autor:
Dominik Trzupek, Melanie Dunstan, Antony J. Cutler, Mercede Lee, Leila Godfrey, Lorna Jarvis, Daniel B. Rainbow, Dominik Aschenbrenner, Joanne L. Jones, Holm H. Uhlig, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-22 (2020)
Abstract Background Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing (scRNA-seq) and antibody-based
Externí odkaz:
https://doaj.org/article/6eeadf402a094fd884bcd1203a87702a
Autor:
Dominik Trzupek, Fiona Hamey, Mercede Lee, John A. Todd, Linda S. Wicker, Ricardo C. Ferreira
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: The characterisation of the peripheral immune system in the autoimmune disease systemic lupus erythematosus (SLE) at the single-cell level has been limited by the reduced sensitivity of current whole-transcriptomic technologies. Here we e
Externí odkaz:
https://doaj.org/article/6f7b8027351748d68ec660fd13021b07
Autor:
Jennifer L. Asimit, Daniel B. Rainbow, Mary D. Fortune, Nastasiya F. Grinberg, Linda S. Wicker, Chris Wallace
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Statistical fine-mapping to pinpoint likely causal variants in a genomic region is complicated by linkage disequilibrium (LD). Here, Asimit et al. compare stepwise and stochastic approaches to fine-mapping and propose a Bayesian multinomial stochasti
Externí odkaz:
https://doaj.org/article/21925d81eaac4ea7a5a05ceb32998ec2