Zobrazeno 1 - 10
of 1 081
pro vyhledávání: '"S Waxman"'
Publikováno v:
PLoS Genetics, Vol 20, Iss 11, p e1011222 (2024)
Nr2f transcription factors (TFs) are conserved regulators of vertebrate atrial cardiomyocyte (AC) differentiation. However, little is known about the mechanisms directing Nr2f expression in ACs. Here, we identified a conserved enhancer 3' to the nr2f
Externí odkaz:
https://doaj.org/article/90ea3797a6a548718a8eb2c725072d6c
Autor:
Jacob T. Gafranek, Enrico D’Aniello, Padmapriyadarshini Ravisankar, Kairavee Thakkar, Ronald J. Vagnozzi, Hee-Woong Lim, Nathan Salomonis, Joshua S. Waxman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract How two-chambered hearts in basal vertebrates have evolved from single-chamber hearts found in ancestral chordates remains unclear. Here, we show that the teleost sinus venosus (SV) is a chamber-like vessel comprised of an outer layer of smo
Externí odkaz:
https://doaj.org/article/b0650cc63eed4e918d41e22172078a89
Autor:
Kendall E Martin, Padmapriyadarshini Ravisankar, Manu Beerens, Calum A MacRae, Joshua S Waxman
Publikováno v:
eLife, Vol 12 (2023)
Maintenance of cardiomyocyte identity is vital for normal heart development and function. However, our understanding of cardiomyocyte plasticity remains incomplete. Here, we show that sustained expression of the zebrafish transcription factor Nr2f1a
Externí odkaz:
https://doaj.org/article/f836804f17944076be9c284e9dd8ddfc
Autor:
Eliyahu Perl, Padmapriyadarshini Ravisankar, Manu E. Beerens, Lejla Mulahasanovic, Kelly Smallwood, Marion Bermúdez Sasso, Carina Wenzel, Thomas D. Ryan, Matej Komár, Kevin E. Bove, Calum A. MacRae, K. Nicole Weaver, Carlos E. Prada, Joshua S. Waxman
Publikováno v:
HGG Advances, Vol 3, Iss 3, Pp 100115- (2022)
Summary: Requirements for vesicle fusion within the heart remain poorly understood, despite the multitude of processes that necessitate proper intracellular trafficking within cardiomyocytes. Here, we show that Syntaxin 4 (STX4), a target-Soluble N-e
Externí odkaz:
https://doaj.org/article/69a4013e43b2410292ce66f8fe329a35
Publikováno v:
eLife, Vol 11 (2022)
Angioblasts that form the major axial blood vessels of the dorsal aorta and cardinal vein migrate toward the embryonic midline from distant lateral positions. Little is known about what controls the precise timing of angioblast migration and their fi
Externí odkaz:
https://doaj.org/article/cb2927aa28a64deaba323e8a39683bbd
Elevated Hoxb5b Expands Vagal Neural Crest Pool and Blocks Enteric Neuronal Development in Zebrafish
Autor:
Aubrey G. A. Howard, Aaron C. Nguyen, Joshua Tworig, Priya Ravisankar, Eileen W. Singleton, Can Li, Grayson Kotzur, Joshua S. Waxman, Rosa A. Uribe
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Neural crest cells (NCCs) are a migratory, transient, and multipotent stem cell population essential to vertebrate embryonic development, contributing to numerous cell lineages in the adult organism. While great strides have been made in elucidating
Externí odkaz:
https://doaj.org/article/b94467df91844b8aa82d5d3a380a1927
Autor:
Lauren G. Falkenberg, Sarah A. Beckman, Padmapriyadarshini Ravisankar, Tracy E. Dohn, Joshua S. Waxman
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 5 (2021)
The pathology of primary ciliary dyskinesia (PCD) is predominantly attributed to impairment of motile cilia. However, PCD patients also have perplexing functional defects in myeloid cells, which lack motile cilia. Here, we show that coiled-coil domai
Externí odkaz:
https://doaj.org/article/7e110db04ec54ef3a3666fc983f4b923
Autor:
Ugo Coppola, Joshua S Waxman
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0254282 (2021)
BackgroundNuclear Receptor Subfamily 2 Group F (Nr2f) orphan nuclear hormone transcription factors (TFs) are fundamental regulators of many developmental processes in invertebrates and vertebrates. Despite the importance of these TFs throughout metaz
Externí odkaz:
https://doaj.org/article/f1903d5cfa3e4cdfa7843e573b915aa9
Publikováno v:
Journal of the Advanced Practitioner in Oncology. 13:579-585
Elizabeth S. Waxman, RN, MSN, AOCN®, ANP-BC, of MD Anderson Cancer Center, reviews research in thoracic cancers presented at the 2022 ASCO Annual Meeting, including neoadjuvant immunotherapy for resectable stage IIIA non–small cell lung cancer, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e56bdd4adefa18cd8a1d35a1aa8fa2f
https://doi.org/10.6004/jadpro.2022.13.6.3
https://doi.org/10.6004/jadpro.2022.13.6.3
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008165 (2019)
Coordinated transcriptional and epigenetic mechanisms that direct development of the later differentiating second heart field (SHF) progenitors remain largely unknown. Here, we show that a novel zebrafish histone deacetylase 1 (hdac1) mutant allele c
Externí odkaz:
https://doaj.org/article/688799c27926458d924ce31a448c670c