Výsledky vyhledávání - "S W Mascarella"

Synthesis and physicochemical characterization of (6S)-5-formiminotetrahydrofolate; a reference standard for metabolomics

Autor: Anita H. Lewin, S. W. Mascarella, Amanda Gilbert, Herbert H. Seltzman, P. Silinski, Desong Zhong

Publikováno v: Organicbiomolecular chemistry. 16(31)

The one-carbon carrier of the formate oxidation level derived from the interaction of tetrahydrofolate and formiminoglutamate, which has been tentatively identified as 5-formiminoltetrahydrofolate, has been prepared by chemical synthesis. Treatment o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a8b47de97164931edf41fd6350346b
https://pubmed.ncbi.nlm.nih.gov/30046777

Zobrazit plný text záznamu

Enantioselective synthesis of strobamine and its analogues

Autor: S. W. Mascarella, F. Ivy Carroll, X. Zhang, Judith L. Flippen-Anderson, Philip Abraham, Jeffrey R. Deschamps

Publikováno v: ARKIVOC, Vol 2010, Iss 4, Pp 96-103 (2010)
ResearcherID

(2S,5S,8R)-Strobamine (+)-1a was synthesized by adding cinnamoyl cyanide 6a to tropinone 3 lithium enolate generated by treatment of (S,S')-alpha, alpha-dimethyldibenzylamide with butyl lithium in the presence of lithium chloride to give (-)-chalcost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29201cb9805745f8d2eafef00ea37fcb
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0011.409

Zobrazit plný text záznamu

1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists

Autor: Juan Pablo Cueva, Frank I. Carroll, Scott P. Runyon, James B. Thomas, Hernán A. Navarro, S. W. Mascarella

Publikováno v: ACS Medicinal Chemistry Letters. 1:365-369

This report describes the discovery that 1-substituted 4-(3-hydroxyphenyl)piperazines are pure opioid receptor antagonists. Compounds in this new series include N-phenylpropyl (3S)-3-methyl-4-(3-hydroxyphenyl)piperazine and (3R)-3-methyl-4-(3-hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2d93f88e1b6bb2c6ee58f87289878b
https://doi.org/10.1021/ml100126b

Zobrazit plný text záznamu

Synthesis and Monoamine Transporter Binding Properties of 2,3-Cyclo Analogues of 3β-(4‘-Aminophenyl)-2β-tropanemethanol

Autor: Carroll Fi, Jeffrey R. Deschamps, S. W. Mascarella, Bruce E. Blough, Zhe Nie, Xiaodong Huang, Hernán A. Navarro

Publikováno v: Journal of Medicinal Chemistry. 49:4589-4594

A series of cyclo-3beta-(4-aminophenyl)-2beta-tropanemethanol analogues (5a-m) possessing varying linker groups between the 2- and 3-position on the tropane ring were synthesized and evaluated for their monoamine transporter binding properties. The r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0def38d634e755d2fbb92a8c9e8589ae
https://doi.org/10.1021/jm060287w

Zobrazit plný text záznamu

Importance of Phenolic Address Groups in Opioid Kappa Receptor Selective Antagonists

Autor: D. M. Zimmerman, S. W. Mascarella, Richard B. Rothman, Carroll Fi, Jim A. Thomas, B. E. Cantrell, Christina M. Dersch, Scott E. Fix

Publikováno v: Journal of Medicinal Chemistry. 47:1070-1073

In vitro characterization and comparison of JDTic, its dehydroxy analogue and nor-BNI, and its dehydroxy analogue demonstrates that the N-substituted 3,4-dimethyl-(3-hydroxyphenyl)piperidine-derived antagonist, JDTic, relies more heavily on its pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b24556bf4151aa3a01efb2f3da289f
https://doi.org/10.1021/jm030467v

Zobrazit plný text záznamu

Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans

Autor: Jim A. Thomas, Robert N. Atkinson, D. M. Zimmerman, Noelle Vinson, Richard B. Rothman, Christina M. Dersch, Kenneth M. Gigstad, Nivedita Namdev, Scott E. Fix, Jason P. Burgess, Heng Xu, F. I. Carroll, S. W. Mascarella, B. E. Cantrell

Publikováno v: Journal of Medicinal Chemistry. 45:3524-3530

A library of compounds biased toward opioid receptor antagonist activity was prepared by incorporating N-phenylpropyl-4beta-methyl-5-(3-hydroxyphenyl)morphans as the core scaffold using simultaneous solution phase synthetic methodology. From this lib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cf41f988f4d576a71855a6c19e3670
https://doi.org/10.1021/jm020084h

Zobrazit plný text záznamu

QSAR Analysis of Δ8-THC Analogues: Relationship of Side-Chain Conformation to Cannabinoid Receptor Affinity and Pharmacological Potency

Autor: Razdan Rk, S. W. Mascarella, PJ Crocker, Alison R. Keimowitz, Billy R. Martin, Brian F. Thomas

Publikováno v: Journal of Medicinal Chemistry. 43:59-70

A novel quantitative structure-activity relationship (QSAR) for the side-chain region of Delta(8)-tetrahydrocannabinol (Delta(8)-THC) analogues is reported. A series of 36 side-chain-substituted Delta(8)-THCs with a wide range of pharmacological pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01896042143e19ecdfca00c46a0d69e1
https://doi.org/10.1021/jm9902281

Zobrazit plný text záznamu

Synthesis, Ligand Binding, and Quantitative Structure−Activity Relationship Study of 3β-(4‘-Substituted phenyl)-2β-heterocyclic Tropanes: Evidence for an Electrostatic Interaction at the 2β-Position

Autor: Carroll Fi, John W. Boja, Michael J. Kuhar, S. W. Mascarella, Anita H. Lewin, Philip Abraham, Pravin Kotian

Publikováno v: Journal of Medicinal Chemistry. 39:2753-2763

A set of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes was designed, synthesized, and characterized. We discovered that these compounds can function as bioisosteric replacements for the corresponding WIN 35,065-2 analogs which possess a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2456b02cc5148ab08529ed93621372f
https://doi.org/10.1021/jm960160e

Zobrazit plný text záznamu

Structure−Activity Analysis of Anandamide Analogs: Relationship to a Cannabinoid Pharmacophore

Autor: Billy R. Martin, S. W. Mascarella, Razdan Rk, Adams Ib, Brian F. Thomas

Publikováno v: Journal of Medicinal Chemistry. 39:471-479

Anandamides are endogenous fatty acid ethanolamides that have been shown to bind to the cannabinoid receptor and possess cannabimimetic activity yet are structurally dissimilar from the classical cannabinoids found in Cannabis sativa. We have employe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566584c4877f181a54845eac948f6780
https://doi.org/10.1021/jm9505167

Zobrazit plný text záznamu

Synthesis and .sigma. Binding Properties of 2'-Substituted 5,9.alpha.-Dimethyl-6,7-benzomorphans

Autor: W. D. Bowen, Wanda Williams, Xu Bai, R. Danso‐Danquah, B. Sine, S. W. Mascarella, X. Zhang, Frank I. Carroll

Publikováno v: Journal of Medicinal Chemistry. 38:2978-2985

The synthesis and sigma 1 and sigma 2 binding properties of several (+)- and (-)-2-benzyl- and 2-dimethylallyl-2'-substituted-5,9 alpha-dimethyl-6,7-benzomorphans (3 and 4) are presented. In agreement with previously reported binding data for 2-subst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19f5984fe860631dbff966d956a1ca6
https://doi.org/10.1021/jm00015a022

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání