Výsledky vyhledávání - "S W Barthold"

Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells

Autor: E Fikrig, S W Barthold, M Chen, C H Chang, R A Flavell

Publikováno v: The Journal of Immunology. 159:5682-5686

Murine Lyme borreliosis is characterized by arthritis and carditis that are most severe at 2 to 3 wk, then regress during the course of persistent infection. Borrelia burgdorferi-specific Abs and CD4+ T cells have been implicated in the resolution ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7977c60fe31417ecec66afa1d63237b9
https://doi.org/10.4049/jimmunol.159.11.5682

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Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice

Autor: L K Bockenstedt, E Fikrig, S W Barthold, R A Flavell, F S Kantor

Publikováno v: The Journal of Immunology. 157:5496-5502

Lyme disease, due to infection with the tick-borne spirochete Borrelia burgdorferi, is a multisystem disorder that can lead to chronic disabling symptoms. Abs to the outer surface protein A (OspA) of B. burgdorferi provide protection against infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::963c890162e3b415b4805c0fd8c467ce
https://doi.org/10.4049/jimmunol.157.12.5496

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An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies

Autor: E Fikrig, B Liu, L L Fu, S Das, J I Smallwood, R A Flavell, D H Persing, R T Schoen, S W Barthold, S E Malawista

Publikováno v: The Journal of Immunology. 155:5700-5704

Passive immunization with murine or human Abs to outer surface protein A (OspA) can protect mice against Borrelia burgdorferi, but OspA Abs elicited during natural infection in mice or humans are unable to clear the spirochete from the infected host.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e97123994c77e60e68d277ce32a11a7f
https://doi.org/10.4049/jimmunol.155.12.5700

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Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice

Autor: L K Bockenstedt, E Fikrig, S W Barthold, F S Kantor, R A Flavell

Publikováno v: The Journal of Immunology. 151:900-906

The murine immune response to Borrelia burgdorferi (Bb), the etiologic agent of Lyme disease, is characterized by the development of antibodies reactive with the outer surface protein (Osp) A. It has been demonstrated that passive immunization of mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a54e473887bd8b29342ec0825c7894c3
https://doi.org/10.4049/jimmunol.151.2.900

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Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection

Autor: E Fikrig, S W Barthold, D H Persing, X Sun, F S Kantor, R A Flavell

Publikováno v: The Journal of Immunology. 148:2256-2260

Mice vaccinated with outer surface protein A (OspA) from Borrelia burgdorferi strain N40 are protected from challenge with an intradermal syringe inoculum of B. burgdorferi strains N40, B31, and CD16. Vaccination experiments were done to determine if

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d01373c2b9037297bc97bea6102bf303
https://doi.org/10.4049/jimmunol.148.7.2256

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Hemangiopericytoma in a rat

Autor: J, Morehead, S W, Barthold

Publikováno v: Contemporary topics in laboratory animal science. 36(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0cbc0db375c4f90d0a25fc4034c35185
https://pubmed.ncbi.nlm.nih.gov/16450971

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Evaluation of diagnostic methods for Helicobacter bilis infection in laboratory mice

Autor: E, Hodzic, M, McKisic, S, Feng, S W, Barthold

Publikováno v: Comparative medicine. 51(5)

Disease-susceptible (C3H) and -resistant (B6) immunocompetent and immunodeficient (C3H-scid and B6-rag1) mice were examined up to 10 weeks after inoculation with Helicobacter bilis (a prototype species of proven virulence). Infection was monitored we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff86ef183c171a35de7ca749804ca461
https://pubmed.ncbi.nlm.nih.gov/11924799

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Central and peripheral nervous system infection, immunity, and inflammation in the NHP model of Lyme borreliosis

Autor: A R, Pachner, D, Cadavid, G, Shu, D, Dail, S, Pachner, E, Hodzic, S W, Barthold

Publikováno v: Annals of neurology. 50(3)

The relationship between chronic infection, antispirochetal immunity, and inflammation is unknown in Lyme neuroborreliosis. In the nonhuman primate model of Lyme neuroborreliosis, we measured spirochetal density in the nervous system and other tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4bb7c8179ff530e9414cfe22ba5434cd
https://pubmed.ncbi.nlm.nih.gov/11558789

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