Zobrazeno 1 - 10
of 44
pro vyhledávání: '"S Wörmann"'
Autor:
Meifang Yu, Jason B. Fleming, Rena Levin-Klein, Steven Gallinger, Susan R. Ross, Cullen M. Taniguchi, Chris Gates, Dhwani N. Rupani, Sara L. Manning, Runsheng Wang, Michael P. Kim, Kimal I. Rajapakshe, Fredrik I. Thege, Reuben S. Harris, Weisheng Wu, S Wörmann, Matthew H G Katz, Faiyaz Notta, Asha S. Multani, Amy Zhang, Ya’an Kang, Anirban Maitra, Andrew D. Rhim, Ravikanth Maddipati, Melena D. Bellin, Robert W. Cowan, Katharina Schlacher
Publikováno v:
Nature Cancer. 2:1338-1356
Despite efforts in understanding its underlying mechanisms, the etiology of chromosomal instability (CIN) remains unclear for many tumor types. Here, we identify CIN initiation as a previously undescribed function for APOBEC3A (A3A), a cytidine deami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04e26ef1ea88554855af0acff0f1d09e
https://doi.org/10.1038/s43018-021-00268-8
https://doi.org/10.1038/s43018-021-00268-8
Autor:
Prerna Malaney, Fredrik I. Thege, Vidhi Chandra, Jack Hashem, Jennifer Bailey-Lundberg, Andrew D. Rhim, Hajar Rajaei, Dhwani N. Rupani, Sara L. Manning, S Wörmann, Olivereen Le Roux, Robert W. Cowan, Florencia McAllister
Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-binding protein that deaminates adenosine(A) to inosine(I). A-to-I editing alters post-transcriptional RNA processing making ADAR1 a critical regulator of gene expression. Consequently, Adar1 has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d197c1a761e9033fce25c9dc651487b
https://doi.org/10.1101/2021.11.03.467127
https://doi.org/10.1101/2021.11.03.467127
Autor:
Jerry Ware, Ilina Laitinen, Parandis Hoseinpour, Sven Stockhausen, Steffen Massberg, Hana Algül, Nigel Mackman, Badr Kilani, Markus Bäumer, Susanne Pfeiler, Christiane J. Bruns, Marie Luise von Brühl, Sue Chandraratne, Michael Lorenz, Urjita Joshi, Irene Schubert, Bernd Engelmann, Manovriti Thakur, Tobias Schmidergall, Konstantin Stark, Sven Reese, Raffaele Coletti, S Wörmann, Petra Grünauer
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:772-786
Objective— Cancer patients are at high risk of developing deep venous thrombosis (DVT) and venous thromboembolism, a leading cause of mortality in this population. However, it is largely unclear how malignant tumors drive the prothrombotic cascade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3630bb3c10df65c845952a7eedca40b9
https://doi.org/10.1161/atvbaha.117.310262
https://doi.org/10.1161/atvbaha.117.310262
Autor:
Alexander Muckenhuber, Dietrich A. Ruess, Maria Kutschke, Kivanc Görgülü, Samuel Hofmann, Rickmer Braren, Katrin J. Ciecielski, Derya Kabacaoglu, Martin Jastroch, Ezgi Kaya-Aksoy, Kalliope N. Diakopoulos, Alexandra Berninger, Hana Algül, Nan Wu, S Wörmann, Irina Heid, Mireia Vallespinós, Marc Riemann, Anna Melissa Schlitter, Roland M. Schmid, Marina Lesina, Ihsan Ekin Demir, Diego Navarro, Sladjana Zagorac, Güralp O. Ceyhan, Bruno Sainz, Marlena Kowalska, Jiaoyu Ai, Sabrina Schreiner, Katja Steiger, Sonia Alcalá, Julia Slotta-Huspenina
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
[Background & Aims]: The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient classification for better decision-making algorithms and personalized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47664f409b470bee4db55636c8f6b4e
https://doi.org/10.1053/j.gastro.2021.03.051
https://doi.org/10.1053/j.gastro.2021.03.051
Publikováno v:
Drugs & Aging. 34:331-357
Pancreatic ductal adenocarcinoma is a devastating malignancy, which is the result of late diagnosis, aggressive disease, and a lack of effective treatment options. Thus, pancreatic ductal adenocarcinoma is projected to become the second leading cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba65906882e5d2b6376abff7ab70aaa
https://doi.org/10.1007/s40266-017-0453-y
https://doi.org/10.1007/s40266-017-0453-y
Autor:
Urjita Joshi, Georg J. Arnold, Remco T. A. Megens, Susanne Pfeiler, Christiane Bruns, Christian Weber, Verena Samara, Geraldine Müller-Stoy, Steffen Massberg, Raffaele Coletti, Petra Grünauer, S Wörmann, Andreas Klingl, Hana Algül, Manovriti Thakur, Konstantin Stark, Hellen Ishikawa-Ankerhold, Thomas Fröhlich, Bernd Engelmann
Publikováno v:
Faseb Journal, 33(2), 1860-1872. FASEB
Tumor microvesicles are a peculiar type of extracellular vesicles that circulate in the blood of patients with metastatic cancer. The itineraries and immune cell interactions of tumor microvesicles during the intravascular and extravascular stages of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97e0463827d0ded96e789d62705049f
https://cris.maastrichtuniversity.nl/en/publications/00fa1707-fbbe-4d40-b4aa-b5c95030f370
https://cris.maastrichtuniversity.nl/en/publications/00fa1707-fbbe-4d40-b4aa-b5c95030f370
Autor:
Jennifer P. Morton, Jan Sperveslage, Hana Algül, Kalliope N. Diakopoulos, Dieter Saur, Owen J. Sansom, Timothy C. Wang, S Wörmann, Ihsan Ekin Demir, Mathias Heikenwalder, Jörg M. Steiner, Henrik Einwächter, Margit Wimmer, Timo Kehl, Bence Sipos, Olga Korneeva, Roland M. Schmid, Marina Lesina
Publikováno v:
Journal of Clinical Investigation
J. Clin. Invest. 126, 2919-2932 (2016)
J. Clin. Invest. 126, 2919-2932 (2016)
Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bac50956a263da9d0b4956c63032e06
https://doi.org/10.1172/jci86477
https://doi.org/10.1172/jci86477
Autor:
Bruno Sainz, S Wörmann, Katrin J. Ciecielski, Maximilian Reichert, Dietrich A. Ruess, Alexandra Berninger, Mert Erkan, Walter Birchmeier, Angeliki Faidra Karpathaki, Liang Song, Kalliope N. Diakopoulos, Jiaoyu Ai, Dieter Saur, Zahra Dantes, Guus J.J.E. Heynen, Derya Kabacaoglu, Marc Nazaré, María P. López-Alberca, Kivanc Görgülü, Marlena Kowalska, Eveline A.N. Zeeuw van der Laan, Ezgi Kaya-Aksoy, Roland M. Schmid, Marina Lesina, Ulrich T. Hopt, Hana Algül
Publikováno v:
Nature Medicine
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, is involved in signal transduction downstream of multiple growth factor, cytokine and integrin receptors1. Its requirement for complete RAS-MAPK activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b3e465c7be3afb8d1cbc64a73dafb0
Publikováno v:
Seminars in Immunology. 26:80-87
Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases is versatile a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e812092efbb5f03380bd8b558e2138f
https://doi.org/10.1016/j.smim.2014.01.002
https://doi.org/10.1016/j.smim.2014.01.002
Autor:
Ezgi Kaya-Aksoy, Katrin J. Ciecielski, Dietrich A. Ruess, Jerzy Adamski, Wilko Weichert, Axel Walch, Hana Algül, Svetlana Voronina, A. V. Tepikin, Götz Hartleben, Jiaoyu Ai, Kalliope N. Diakopoulos, Thomas Wartmann, Kivanc Görgülü, Marija Stevanovic, Achim Krüger, Anna Melissa Schlitter, Marina Lesina, Angeliki Faidra Karpathaki, Alexandra Berninger, Martin Jastroch, Anna Artati, Benjamin Schoeps, Marlena Kowalska, Roland M. Schmid, Bruno Sainz, Derya Kabacaoglu, Walter Halangk, Yue Zhao, Michaela Aichler, S Wörmann, Stephan Herzig, Christos S. Mantzoros, Katja Steiger
Publikováno v:
Gastroenterology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
[Background and Aims]: Cells in pancreatic ductal adenocarcinoma (PDAC) undergo autophagy, but its effects vary with tumor stage and genetic factors. We investigated the consequences of varying levels of the autophagy related 5 (Atg5) protein on panc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ea79698b1a20a100a951af2c1d3ab4
https://doi.org/10.1053/j.gastro.2018.09.053
https://doi.org/10.1053/j.gastro.2018.09.053