Zobrazeno 1 - 10
of 16
pro vyhledávání: '"S W, Watts"'
Publikováno v:
British journal of pharmacology. 154(3)
5-HT is a vasoconstrictor exhibiting enhanced effects in systemic arteries from subjects with cardiovascular disease. The effect of endogenous 5-HT on arteries is controversial, because the concentration of free circulating 5-HT is low and a 5-hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38f392d6e1f78d3746f9c0743b028ae0
https://pubmed.ncbi.nlm.nih.gov/18414394
https://pubmed.ncbi.nlm.nih.gov/18414394
Autor:
C M, McKune, S W, Watts
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(1)
The purpose of this study was to characterize pharmacologically the 5-HT receptor(s) mediating contraction in the mouse aorta and the pathways these receptors are coupled with to mediate contraction. We hypothesized that a 5-HT2A receptor, as in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4453ea4d7483861d7b0ac9b7dc6f08a
https://pubmed.ncbi.nlm.nih.gov/11259531
https://pubmed.ncbi.nlm.nih.gov/11259531
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(2)
Hypertension produced by chronic infusion of angiotensin II (Ang II) is significantly blunted by blockade of endothelin-1 (ET-1) ET(A) subtype receptors. Furthermore, this model is salt-sensitive, and the antihypertensive response to ET(A) receptor b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb454bdec94a961d8b7715d11dc4553a
https://pubmed.ncbi.nlm.nih.gov/11160616
https://pubmed.ncbi.nlm.nih.gov/11160616
Publikováno v:
General pharmacology. 34(2)
This study tests the hypothesis that insulin-like growth factor 1 (IGF-1)-induced vasodilation is due to the stimulation of tyrosine phosphatase. Rat aortic segments (endothelium intact) were placed in muscle baths for force measurement. Segments wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f22c82213b735ba8faba1b76f92cf5ba
https://pubmed.ncbi.nlm.nih.gov/10974421
https://pubmed.ncbi.nlm.nih.gov/10974421
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(3)
5-Hydroxytryptamine (5-HT) activates the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinases (MAPKs) in the vasculature, resulting in contraction. The mechanisms by which this occurs are unclear. G protein-coupled receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5343cb1089f3c13b619ab33c1e802b75
https://pubmed.ncbi.nlm.nih.gov/10565840
https://pubmed.ncbi.nlm.nih.gov/10565840
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(3)
Angiotensin II (Ang II) is a potent pressor hormone, a stimulus for vascular smooth muscle hypertrophy and an activator of multiple tyrosine kinases. The physiological effects of Ang II are mediated through activation of AT1 and AT2 receptors, recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c0a1b48691fc95fe1e890967c0e36dc
https://pubmed.ncbi.nlm.nih.gov/9732408
https://pubmed.ncbi.nlm.nih.gov/9732408
Autor:
J A, Florian, S W, Watts
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(1)
Vascular 5-Hydroxytryptamine2A (5-HT2A) receptor signaling and contraction has been associated with the activation of L-type calcium channels, phospholipase C (PLC) and, as we previously demonstrated, tyrosine kinase activation. We hypothesize the 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7238e5f938e489fd705cfcc18988a5e7
https://pubmed.ncbi.nlm.nih.gov/9435197
https://pubmed.ncbi.nlm.nih.gov/9435197
Publikováno v:
The American journal of physiology. 273(1 Pt 2)
Portal venous infusion of oleate solution has pressor effects. We have examined efferent mechanisms, measured the response to sustained infusion, and determined the effect of linoleate. Eight conscious animals received concurrent infusions of prazosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772a9bd2ca849fd1e4fa1a350249c021
https://pubmed.ncbi.nlm.nih.gov/9249567
https://pubmed.ncbi.nlm.nih.gov/9249567
Autor:
S W, Watts
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(3)
Serotonin (5-hydroxytryptamine, 5-HT) promotes changes in vascular smooth muscle contractility and is a vascular smooth muscle mitogen. The hypothesis that 5-HT-induced arterial contraction is partially dependent on tyrosine kinase activation was tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::594578d40a336ea03a1d3cc013a26cd0
https://pubmed.ncbi.nlm.nih.gov/8968381
https://pubmed.ncbi.nlm.nih.gov/8968381
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
One of the most profound increases in vascular responsiveness in hypertension has been observed for serotonin (5-hydroxytryptamine, 5-HT). This study investigates the hypothesis that the increase in vascular responsiveness to 5-HT is the result of al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7df8d1cea9de24bd13d0788352339676
https://pubmed.ncbi.nlm.nih.gov/8627522
https://pubmed.ncbi.nlm.nih.gov/8627522