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Open-label efficacy and safety trial of 42 days of 566C80 for Pneumocystis carinii pneumonia in AIDS patients

Autor: M N, Dohn, P T, Frame, R P, Baughman, S W, Lafon, A G, Smulian, P, Caldwell, M D, Rogers

Publikováno v: The Journal of protozoology. 38(6)

Pneumocystis carinii pneumonia continues to be a cause of morbidity and mortality in AIDS patients. Current therapies have a high rate of toxicity and failure. Compound 566C80 is a 1-4,hydroxynaphthoquinone with potent antiprotozoal activity which sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::175abde683f6a502f118c919e92e20db
https://pubmed.ncbi.nlm.nih.gov/1818178

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Antiprotozoal activity of 3'-deoxyinosine. Inverse correlation to cleavage of the glycosidic bond

Autor: A R, Moorman, S W, LaFon, D J, Nelson, H H, Carter, J J, Marr, R L, Berens

Publikováno v: Biochemical pharmacology. 42(2)

Two nucleosides related to the known antiprotozoal agent 1-(beta-D-ribofuranosyl)-1,5-dihydro-4H-pyrazolo-[3,4-d]pyrimidine-4-one (allopurinol riboside, 1) were prepared and evaluated against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b07105c44de42de0d4328927c171d1b4
https://pubmed.ncbi.nlm.nih.gov/1859443

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Inosine analogs. Their metabolism in mouse L cells and in Leishmania donovani

Autor: J. Joseph Marr, Randolph L. Berens, D J Nelson, S W LaFon

Publikováno v: Journal of Biological Chemistry. 260:9660-9665

The growth of Leishmania donovani promastigotes and mouse L cells is differentially inhibited by several inosine analogs with modifications in the imidazole ring. The protozoal and mammalian cells also demonstrate differential metabolism of these ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46000d4648cd5ff8b802ab1913ae3a0a
https://doi.org/10.1016/s0021-9258(17)39289-x

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Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation

Autor: Randolph L. Berens, Wayne H. Miller, Gertrude B. Elion, D J Nelson, S W LaFon, Richard L. Miller, Joel Van Tuttle, J. Joseph Marr, Thomas A. Krenitsky

Publikováno v: Journal of Biological Chemistry. 254:11544-11549

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eca589d8209bef5bd3d0ba2042a445dc
https://doi.org/10.1016/s0021-9258(19)86518-3

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Antileishmanial action of 4-thiopyrazolo (3.4-d) pyrimidine and its ribonucleoside. Biological effects and metabolism

Autor: J J, Marr, R L, Berens, D J, Nelson, T A, Krenitsky, T, Spector, S W, LaFon, G B, Elion

Publikováno v: Biochemical pharmacology. 31(2)

Thiopurinol [4-thiopyrazolo(3.4-dyprimidine, TPP] and its ribonucleoside (TPPR) were effective in vitro against the intracellular and extracellular forms of L. braziliensis and L. mexicana. They also inhibited the transformation of the amastigote of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::405c1c1ed600763ea16020a8efdd6487
https://pubmed.ncbi.nlm.nih.gov/7073876

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6-Thiopurine riboside analogs: their toxicity and metabolism in Leishmania donovani and mammalian cells

Autor: S W, LaFon, N K, Cohn, D J, Nelson, R L, Berens

Publikováno v: Advances in experimental medicine and biology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fd69022ccdf647b14b3b147f4cef356
https://pubmed.ncbi.nlm.nih.gov/3766244

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Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation

Autor: D J, Nelson, S W, LaFon, J V, Tuttle, W H, Miller, R L, Miller, T A, Krenitsky, G B, Elion, R L, Berens, J J, Marr

Publikováno v: The Journal of biological chemistry. 254(22)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc7020b5fd3bcf1eedaafb82bf8690a9
https://pubmed.ncbi.nlm.nih.gov/500658

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Inosine analogs. Their metabolism in mouse L cells and in Leishmania donovani

Autor: S W, LaFon, D J, Nelson, R L, Berens, J J, Marr

Publikováno v: The Journal of biological chemistry. 260(17)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9766c5cd40ec23f54af11345c920d0d9
https://pubmed.ncbi.nlm.nih.gov/4019491

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Monophosphates of formycin B and allopurinol riboside. Interactions with leishmanial and mammalian succino-AMP synthetase and GMP reductase

Autor: T, Spector, T E, Jones, S W, LaFon, D J, Nelson, R L, Berens, J J, Marr

Publikováno v: Biochemical pharmacology. 33(10)

Formycin B 5'-monophosphate (Form B-MP) and allopurinol riboside 5'-monophosphate ( HPPR -MP) are isomers of IMP that are metabolically produced when Leishmania spp. are incubated with the antileishmanial agents formycin B and allopurinol or allopuri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f39b0392d9a6a5e1beb75fdcce5ad7c1
https://pubmed.ncbi.nlm.nih.gov/6732835

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