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Akademický článek

Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells

Autor: Yuchuan Li, Manoj Amrutkar, Anette Vefferstad Finstadsveen, Knut Tomas Dalen, Caroline S. Verbeke, Ivar P. Gladhaug

Publikováno v: Cancer Cell International, Vol 23, Iss 1, Pp 1-20 (2023)

Abstract Background Despite therapeutic advances, the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Metabolic reprogramming is increasingly recognized as a key contributor to tumor progression and therapy resistance in

Externí odkaz: https://doaj.org/article/74434962bd09482d846da247de4e9099

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Akademický článek

Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis

Autor: Manoj Amrutkar, Kjersti Berg, Aina Balto, Miguel G. Skilbrei, Anette V. Finstadsveen, Monica Aasrum, Ivar P. Gladhaug, Caroline S. Verbeke

Publikováno v: Cancer Cell International, Vol 23, Iss 1, Pp 1-17 (2023)

Abstract Background Profound resistance to chemotherapy remains a major challenge in achieving better clinical outcomes for patients with pancreatic ductal adenocarcinoma (PDAC). Recent studies indicate that gemcitabine (GEM) resistance is promoted b

Externí odkaz: https://doaj.org/article/0a8551fe28fd4ded98dac870dafde5e6

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Akademický článek

Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma

Autor: Manoj Amrutkar, Caroline S. Verbeke, Anette Vefferstad Finstadsveen, Linda Dorg, Knut Jørgen Labori, Ivar P. Gladhaug

Publikováno v: Molecular Oncology, Vol 17, Iss 1, Pp 59-81 (2023)

The modest clinical benefits of neoadjuvant chemotherapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) are associated with a lack of robust data on treatment‐induced changes in the tumor. To this end, comparative proteomic profiling of tumor tis

Externí odkaz: https://doaj.org/article/fe5b77bf594f407d93f1ecf9688ee52d

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Akademický článek

GSK3-beta as a candidate therapeutic target in soft tissue sarcomas

Autor: S. Verbeke, R. Perret, V. Chaire, E. Richard, V. Velasco, F. Giles, L. Cavalcante, A. Italiano

Publikováno v: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)

Abstract Soft tissue sarcoma (STS) is a predominantly fatal rare malignancy with inadequate treatment options. Glycogen synthase kinase 3β (GSK-3β) is an emerging target in human malignancies. Its therapeutic relevance in STS is unknown. We analyze

Externí odkaz: https://doaj.org/article/cbb98c95e2e745d88a7d6d2402a0a230

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Akademický článek

European Guideline on IgG4-related Digestive Disease — UEG and SGF Evidence-based Recommendations

Publikováno v: Российский журнал гастроэнтерологии, гепатологии, колопроктологии, Vol 31, Iss 1, Pp 80-114 (2021)

The overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only

Externí odkaz: https://doaj.org/article/a041ede29ff947239e20fb7d20b7781d

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Akademický článek

Biomaterial-based scaffold for in situ chemo-immunotherapy to treat poorly immunogenic tumors

Autor: Hua Wang, Alexander J. Najibi, Miguel C. Sobral, Bo Ri Seo, Jun Yong Lee, David Wu, Aileen Weiwei Li, Catia S. Verbeke, David J. Mooney

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

The immunosuppressive tumour microenvironment impairs immunotherapy in poorly immunogenic cancer. Here, the authors load an alginate gel with GM-CSF, CpG oligonucleotides and doxorubicin-iRGD to promote immunogenic death of tumour cells and improve i

Externí odkaz: https://doaj.org/article/2af10e759cc3482da0ca26d55a1844d7

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Akademický článek

Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

Autor: Manoj Amrutkar, Monica Aasrum, Caroline S. Verbeke, Ivar P. Gladhaug

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-16 (2019)

Abstract Background Gemcitabine remains a cornerstone in chemotherapy of pancreatic ductal adenocarcinoma (PDAC) despite suboptimal clinical effects that are partly due to the development of chemoresistance. Pancreatic stellate cells (PSCs) of the tu

Externí odkaz: https://doaj.org/article/c056b0f49e6d4e2ba4b1c4847316ec3b

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Transcriptomic and clinical heterogeneity of metastatic disease timing within metastatic castration-sensitive prostate cancer

Publikováno v: Annals of Oncology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f30e08f5d0886c0691c437a37d8e426
https://doi.org/10.1016/j.annonc.2023.04.515

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Akademický článek

Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor

Autor: Manoj Amrutkar, Emma Kristine Larsen, Monica Aasrum, Anette Vefferstad Finstadsveen, Per Arne Andresen, Caroline S. Verbeke, Ivar P. Gladhaug

Publikováno v: Cells, Vol 9, Iss 1, p 227 (2020)

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely poor prognosis, and its treatment remains a challenge. As the existing in vitro experimental models offer only a limited resemblance to human PDAC, there is a strong need for ad

Externí odkaz: https://doaj.org/article/e017ea439478445bb8d912819d80296a

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Akademický článek

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