Zobrazeno 1 - 10
of 480
pro vyhledávání: '"S Van Dongen"'
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-21 (2024)
Abstract Background During the previous two decades, PET imaging of biopharmaceuticals radiolabeled with zirconium-89 has become a consistent tool in preclinical and clinical drug development and patient selection, primarily due to its advantageous p
Externí odkaz:
https://doaj.org/article/bc06d18625874015acb5db58734cf373
Autor:
Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Background Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irreversible uptake ma
Externí odkaz:
https://doaj.org/article/e2826c2a0dcd4ad8b44c5b0685c08e6a
Autor:
Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier, Albert D. Windhorst
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Background Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the re
Externí odkaz:
https://doaj.org/article/625cc69bf6ed4690bf32bf9fa866699c
Autor:
Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman
Publikováno v:
EJNMMI Physics, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Background PET scans using zirconium-89 labelled monoclonal antibodies (89Zr-mAbs), known as 89Zr-immuno-PET, are made to measure uptake in tumour and organ tissue. Uptake is related to the supply of 89Zr-mAbs in the blood. Measuring activit
Externí odkaz:
https://doaj.org/article/94a232ec570a4e688f5d66db698daa4a
Autor:
Ananthi Somasundaram, David Vállez García, Elisabeth Pfaehler, Yvonne W. S. Jauw, Josée M. Zijlstra, Guus A. M. S. van Dongen, Willemien C. Menke-van der Houven van Oordt, Marc C. Huisman, Elisabeth G. E. de Vries, Ronald Boellaard
Publikováno v:
EJNMMI Physics, Vol 9, Iss 1, Pp 1-13 (2022)
Abstract Purpose Low photon count in 89Zr-Immuno-PET results in images with a low signal-to-noise ratio (SNR). Since PET radiomics are sensitive to noise, this study focuses on the impact of noise on radiomic features from 89Zr-Immuno-PET clinical im
Externí odkaz:
https://doaj.org/article/e68e45dee393427aba60c8fc28f050d3
Autor:
Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah, Yvonne W. S. Jauw
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Background 89Zirconium-immuno-positron emission tomography (89Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target concentration to
Externí odkaz:
https://doaj.org/article/7ca500900e7d40a997a3ff94b199da2c
Autor:
E. Madissoon, A. Wilbrey-Clark, R. J. Miragaia, K. Saeb-Parsy, K. T. Mahbubani, N. Georgakopoulos, P. Harding, K. Polanski, N. Huang, K. Nowicki-Osuch, R. C. Fitzgerald, K. W. Loudon, J. R. Ferdinand, M. R. Clatworthy, A. Tsingene, S. van Dongen, M. Dabrowska, M. Patel, M. J. T. Stubbington, S. A. Teichmann, O. Stegle, K. B. Meyer
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-16 (2019)
Abstract Background The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such an atlas. However, delays between fresh
Externí odkaz:
https://doaj.org/article/3e59212c239c4ce79059bf72833722a9
Autor:
Antonia Högnäsbacka, Alex J. Poot, Danielle J. Vugts, Guus A. M. S. van Dongen, Albert D. Windhorst
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 450 (2022)
Multiple small molecule PET tracers have been developed for the imaging of the epidermal growth factor receptor (EGFR). These tracers target the tyrosine kinase (TK) domain of the receptor and have been used for both quantifying EGFR expression and t
Externí odkaz:
https://doaj.org/article/2d2991e893e04fb0869a05e61740c912
Autor:
Kikkie Poels, Maxime Schreurs, Matthijs Jansen, Danielle J. Vugts, Tom T. P. Seijkens, Guus A. M. S. van Dongen, Esther Lutgens, Wissam Beaino
Publikováno v:
Biology, Vol 11, Iss 3, p 408 (2022)
Non-invasive imaging of atherosclerosis can help in the identification of vulnerable plaque lesions. CD40 is a co-stimulatory molecule present on various immune and non-immune cells in the plaques and is linked to inflammation and plaque instability.
Externí odkaz:
https://doaj.org/article/baeddd1d157b4537b632f02c57d06437
Autor:
N. Stergiou, T. E. Wuensche, M. Schreurs, I. Mes, M. Verlaan, E. J. M. Kooijman, A. D. Windhorst, L. Helboe, S. Vergo, S. Christensen, A. A. Asuni, A. Jensen, G. A. M. S. Van Dongen, B. Bang-Andersen, D. J. Vugts, W. Beaino
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging, 50(5), 1306-1317. Springer Verlag
Stergiou, N, Wuensche, T E, Schreurs, M, Mes, I, Verlaan, M, Kooijman, E J M, Windhorst, A D, Helboe, L, Vergo, S, Christensen, S, Asuni, A A, Jensen, A, van Dongen, G A M S, Bang-Andersen, B, Vugts, D J & Beaino, W 2023, ' Application of 89Zr-DFO*-immuno-PET to assess improved target engagement of a bispecific anti-amyloid-ß monoclonal antibody ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 50, no. 5, pp. 1306-1317 . https://doi.org/10.1007/s00259-023-06109-3
Stergiou, N, Wuensche, T E, Schreurs, M, Mes, I, Verlaan, M, Kooijman, E J M, Windhorst, A D, Helboe, L, Vergo, S, Christensen, S, Asuni, A A, Jensen, A, van Dongen, G A M S, Bang-Andersen, B, Vugts, D J & Beaino, W 2023, ' Application of 89Zr-DFO*-immuno-PET to assess improved target engagement of a bispecific anti-amyloid-ß monoclonal antibody ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 50, no. 5, pp. 1306-1317 . https://doi.org/10.1007/s00259-023-06109-3
Purpose The recent conditional FDA approval of Aducanumab (Adu) for treating Alzheimer’s disease (AD) and the continued discussions around that decision have increased interest in immunotherapy for AD and other brain diseases. Reliable techniques f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d269ebb8a676eb2d9dd830aa5a138c8
https://doi.org/10.1007/s00259-023-06109-3
https://doi.org/10.1007/s00259-023-06109-3