Zobrazeno 1 - 10
of 14
pro vyhledávání: '"S V Kashmiri"'
Autor:
F, Guadagni, J, Kantor, S, Aloe, M D, Carone, A, Spila, R, D'Alessandro, M R, Abbolito, M, Cosimelli, F, Graziano, F, Carboni, S, Carlini, P, Perri, F, Sciarretta, J W, Greiner, S V, Kashmiri, S M, Steinberg, M, Roselli, J, Schlom
Publikováno v:
Cancer research. 61(6)
The use of reverse transcription-PCR (RT-PCR) to analyze cells in the blood of cancer patients for the detection of mRNA expressed in tumor cells has implications for both the prognosis and the monitoring of cancer patients for the efficacy of establ
Autor:
D J, Buchsbaum, B E, Rogers, M B, Khazaeli, M S, Mayo, D E, Milenic, S V, Kashmiri, C J, Anderson, L L, Chappell, M W, Brechbiel, D T, Curiel
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5
Novel strategies to increase the therapeutic ratio in clinical radioimmunotherapy studies are needed. Limitations to radioimmunotherapy include bone marrow suppression due to the long circulating half-life of radiolabeled monoclonal antibodies (mAbs)
Generation and characterization of a single gene-encoded single-chain-tetravalent antitumor antibody
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5
Monoclonal antibody (mAb) CC49, a murine IgG1, reacts with the tumor-associated glycoprotein-72 expressed on a variety of carcinomas. In clinical trials, radiolabeled CC49 has shown excellent tumor localization to a variety of carcinomas. To minimize
Publikováno v:
Cancer gene therapy. 4(4)
While in vivo gene inoculation is being increasingly exploited to express genes of choice and elicit specific immune responses in animal models, the utility of this method has not been explored extensively for the expression of antibody genes. The pr
Autor:
D C, Slavin-Chiorini, S V, Kashmiri, J, Schlom, B, Calvo, L M, Shu, M E, Schott, D E, Milenic, P, Snoy, J, Carrasquillo, K, Anderson
Publikováno v:
Cancer research. 55
CC49 is a second-generation monoclonal antibody (MAb) that has high affinity for the tumor-associated pancarcinoma antigen tumor-associated glycoprotein-72. In clinical trials using gamma scanning, radiolabeled CC49 has facilitated the detection of m
Autor:
C M, Nicolet, J K, Burkholder, J, Gan, J, Culp, S V, Kashmiri, J, Schlom, N S, Yang, P M, Sondel
Publikováno v:
Cancer gene therapy. 2(3)
We have used a particle-mediated gene transfer method to analyze the posttransfection expression pattern of an antibody-cytokine fusion protein (FP) in vivo. The FP, denoted CC49-IL2, consists of a single-chain antibody containing the antigen recogni
Publikováno v:
Cancer. 73
Numerous monoclonal antibodies (MoAb) have been developed and currently are being evaluated in both diagnostic and therapeutic clinical trials. Despite the major advances fostered by MoAb technology, several limitations inherent to the use of MoAb ex
Publikováno v:
Journal of Virology. 49:583-587
The two species of covalently closed circular DNA molecules of bovine leukemia virus were cloned in the lambda phage vector lambda gtWES X lambda B. Of the nine independent recombinant lambda-bovine leukemia virus clones that were analyzed, three wer
Autor:
Beryl M. Benjers, D Hopkins, Judith G. Levin, B J O'Neill, Brenda I. Gerwin, Alan Rein, S V Kashmiri, Robert H. Bassin
Publikováno v:
Journal of virology. 31(3)
A nonconditional mutant of B-tropic murine leukemia virus (MuLV), defective in polymerase, has been isolated by cloning chronically infected cells. The cell clone containing the mutant produced virus particles which were noninfectious. However, super
Publikováno v:
Journal of virology. 45(3)
Cocultivation of uninfected and bovine leukemia virus-producing bat cells yielded, in addition to the unintegrated linear DNA duplex, DNA molecules that migrated as 4.4- and 4.8-kilobase-pair DNA fragments in gel electrophoresis. These DNA molecules