Zobrazeno 1 - 10
of 12
pro vyhledávání: '"S V Johann"'
Autor:
Girija Krishnamurthy, Huiming Cheng, Anita Y. M. Howe, S V Johann, Srinivas K. Chunduru, Tarek S. Mansour, John O'Connell, Stanley Mullen, Dorothy C. Young, Joel Bard, Rajiv Chopra
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:3327-3338
HCV-796 selectively inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. In hepatoma cells containing a genotype 1b HCV replicon, HCV-796 reduced HCV RNA levels by 3 to 4 log 10 HCV copies/μg total RNA (the concentration of the compou
Autor:
Srinivas K. Chunduru, John W. Ellingboe, Huiming Cheng, Boris Feld, John O'Connell, Carl J. Baldick, Matthew W. Olson, Ian J. Thompson, Tarek S. Mansour, Michelle L. Kimberland, Marja van Zeijl, Girija Krisnamurthy, Christopher A. Benetatos, Joel S. Christensen, Dorothy C. Young, Ariamala Gopalsamy, Mark Orlowski, Steve Swanberg, Glen A. Coburn, Megan Thorn, Alfred M. Del Vecchio, Johnathan Bloom, Xiaoqun Jiang, S V Johann, Janis Upeslacis, Marc S. Collett, William P. Gorczyca, Anita Y. M. Howe, Steve Herrmann
Publikováno v:
Antimicrobial Agents and Chemotherapy
A novel nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), [(1 R )-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyano[3,4-b]indol-1-yl] acetic acid (HCV-371), was discovered through high-throughput screening follow
Autor:
Vladimir I. Razinkov, Bloom Jonathan David, John O'Connell, S V Johann, Shi-Wu Lee, Robert J. Visalli, Boris Feld, Thomas R. Jones
Publikováno v:
Journal of Virology. 78:1289-1300
A novel small molecule inhibitor of human cytomegalovirus (HCMV) was identified as the result of screening a chemical library by using a whole-virus infected-cell assay. Synthetic chemistry efforts yielded the analog designated CFI02, a compound whos
Autor:
S V Johann, Morin John Edward, Bloom Jonathan David, Larocque James Paul, Boris Feld, Bryan Mark O'hara, Jeanette Fairhurst, Steven K. Vernon, Marja van Zeijl, Thomas R. Jones
Publikováno v:
Journal of Virology. 74:9054-9061
The herpesvirus family has many members that are human pathogens and make a significant contribution to morbidity and mortality associated with viral diseases. Based on criteria such as host cell specificity, oncogenicity, length of replication cycle
Publikováno v:
Journal of Virology. 71:7619-7622
Pit1, the receptor for gibbon ape leukemia virus (GALV), is proposed to be an integral membrane protein with five extracellular loops. Chimeras made between Pit1 homologs differing in permissivity for infection and between Pit1 and the related protei
Publikováno v:
Pedersen, L, Johann, S V, van Zeijl, M, Pedersen, F S & O'Hara, B 1995, ' Chimeras of receptors for gibbon ape leukemia virus/feline leukemia virus B and amphotropic murine leukemia virus reveal different modes of receptor recognition by retrovirus ', Journal of Virology, vol. 69, no. 4, pp. 2401-2405 .
Glvr1 encodes the human receptor for gibbon ape leukemia virus (GALV) and feline leukemia virus subgroup B (FeLV-B), while the related gene Glvr2 encodes the human receptor for amphotropic murine leukemia viruses (A-MLVs). The two proteins are 62% id
Publikováno v:
Journal of Virology. 67:6733-6736
Expression of human GLVR1 in mouse cells confers susceptibility to infection by gibbon ape leukemia virus (GALV), while the normally expressed mouse Glvr-1 does not. Since human and murine GLVR1 proteins differ at 64 positions in their sequences, som
Autor:
S. V. Johann, Robin A. Weiss, Yasuhiro Takeuchi, Chetankumar S. Tailor, B. O'hara, Mary Collins
Publikováno v:
Journal of Virology. 67:6737-6741
The three type C retroviruses, gibbon ape leukemia virus (GALV), simian sarcoma-associated virus (SSAV), and feline leukemia virus subgroup B (FeLV-B), infect human cells by interacting with the same cell surface receptor, GLVR1. Using LacZ retrovira
Publikováno v:
Journal of Virology. 70:6402-6404
The effect of human cytomegalovirus infection on cellular DNA synthesis in human fibroblasts was measured by fluorometry and by incorporation of radiolabeled thymidine. The results show that although HCMV infection stimulates cellular DNA synthesis i
Autor:
J Cunningham, R. L. Eddy, O'hara Bryan Mark, M van Zeijl, S V Johann, Ellen I. Closs, T B Shows
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 91(3)
Retrovirus infection is initiated by binding of the viral envelope glycoprotein to a cell-surface receptor. The envelope proteins of type C retroviruses of mammals demonstrate similarities in structural organization and protein sequence. These simila