Zobrazeno 1 - 10
of 76
pro vyhledávání: '"S V, Pizzo"'
Publikováno v:
Journal of cellular biochemistry. 112(6)
Receptor-recognized forms of α₂ -macroglobulin (α₂ M) bind to cell surface-associated GRP78 and initiate pro-proliferative and anti-apoptotic signaling. Ligation of GRP78 with α₂ M also upregulates TFII-I, which binds to the GRP78 promoter a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::382ce3747dfa091eefa6a988c1d62b67
https://pubmed.ncbi.nlm.nih.gov/21503958
https://pubmed.ncbi.nlm.nih.gov/21503958
Publikováno v:
The Journal of Immunology. 150:48-58
Macrophages secrete alpha 2-macroglobulin (alpha 2M), a protein that may facilitate early Ag handling. alpha 2M is able to entrap and form covalent linkages with diverse proteins during a transient proteinase-activated state. The resulting complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::903f15b852dc605fc1cebb211db9706a
https://doi.org/10.4049/jimmunol.150.1.48
https://doi.org/10.4049/jimmunol.150.1.48
Autor:
M, Cuchacovich, G, Merino, J H, Yamamoto, F, Villarroel, T, Saavedra, S, Jofre, H, Gatica, V, Velasquez, S V, Pizzo, M, Gonzalez-Gronow
Publikováno v:
Clinical and experimental rheumatology. 23(4 Suppl 38)
Lipoteichoic acid (LTA), induces some of the clinical symptoms of Behçet's disease (BD) in a rat animal model. These results led to the hypothesis that LTA may also trigger BD in humans. We investigated the humoral and cellular immune response again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5d6cd9c59be510c21d0d566f48e8054
https://pubmed.ncbi.nlm.nih.gov/16273761
https://pubmed.ncbi.nlm.nih.gov/16273761
Publikováno v:
Journal of leukocyte biology. 70(4)
Apolipoprotein E (ApoE) is a 34-kDa cholesterol transport protein that also possesses immunomodulatory properties. In this study, we demonstrate that ApoE initiates a signaling cascade in murine peritoneal macrophages that leads to increased producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ac752a393e6f465437cf50cb052c1cf
https://pubmed.ncbi.nlm.nih.gov/11590206
https://pubmed.ncbi.nlm.nih.gov/11590206
Publikováno v:
The Journal of biological chemistry. 276(45)
We have previously shown that antigens complexed to the receptor-recognized form of alpha(2)-macroglobulin (alpha(2)M*) demonstrate enhanced immune responsiveness mediated by the low density lipoprotein receptor-related protein LRP/CD91. Recently, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84cc28a0f0143e3e23a4aab5dcac9329
https://pubmed.ncbi.nlm.nih.gov/11514568
https://pubmed.ncbi.nlm.nih.gov/11514568
Autor:
T L, Moser, D J, Kenan, T A, Ashley, J A, Roy, M D, Goodman, U K, Misra, D J, Cheek, S V, Pizzo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(12)
Angiostatin blocks tumor angiogenesis in vivo, almost certainly through its demonstrated ability to block endothelial cell migration and proliferation. Although the mechanism of angiostatin action remains unknown, identification of F1-FO ATP synthase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::911c2d1fc976cbb42928db7ba971f36e
https://pubmed.ncbi.nlm.nih.gov/11381144
https://pubmed.ncbi.nlm.nih.gov/11381144
Publikováno v:
The Biochemical journal. 355(Pt 2)
Both plasminogen (Pg) activation and matrix metalloproteinases (MMPs) are involved in the proteolytic degradation of extracellular matrix components, a requisite event for malignant cell metastasis. The highly invasive 1-LN human prostate tumour cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95f9dd02af294fc30ddf7974dfebca7b
https://pubmed.ncbi.nlm.nih.gov/11284727
https://pubmed.ncbi.nlm.nih.gov/11284727
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(11)
We have studied the effects of the immunosuppressive drug cyclosporin A (CsA) on the generation of inositol 1,4,5-trisphosphate (IP3) and intracellular Ca2+ levels elicited upon ligation of murine macrophage receptors for alpha2-macroglobulin, bradyk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e85c5ab1ca4f20870edcffd0b151b547
https://pubmed.ncbi.nlm.nih.gov/9834096
https://pubmed.ncbi.nlm.nih.gov/9834096
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(8)
Alpha2M binds specifically to TNF-alpha, IL-1beta, IL-2, IL-6, IL-8, basic fibroblast growth factor (bFGF), beta-nerve growth factor (beta-NGF), platelet-derived growth factor (PDGF), and TGF-beta. Since many of these cytokines are released along wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13974763589688f01bcb5dc2b03f3f17
https://pubmed.ncbi.nlm.nih.gov/9780213
https://pubmed.ncbi.nlm.nih.gov/9780213
Autor:
U K, Misra, S V, Pizzo
Publikováno v:
Biochimica et biophysica acta. 1401(1)
We have previously reported that receptor-recognized forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M) bind to a distinct receptor (alpha2MSR), Kd approximately 50-100 pM, activating a signaling cascade, triggering tyrosine phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d692c9b09b8fb806ae44d871a4b5f38a
https://pubmed.ncbi.nlm.nih.gov/9459492
https://pubmed.ncbi.nlm.nih.gov/9459492