Zobrazeno 1 - 10
of 11
pro vyhledávání: '"S T. Forgue"'
Autor:
Lan Ni, Thierry Le Chevalier, S T. Forgue, Mario Di Palma, Antonio Llombart, Suzette Delaloge, Jean-Marc Tourani, Francois Turpin
Publikováno v:
American Journal of Clinical Oncology. 27:289-293
The purpose of this phase I study was to determine the pharmacokinetics and toxicity of gemcitabine in patients with advanced, recurrent, and/or metastatic cancer and renal impairment. Patients were entered in 4 groups estimated by EDTA-Cr plasma cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4ca876a4716264c509a8969aa473cb
https://doi.org/10.1097/01.coc.0000071382.14174.c5
https://doi.org/10.1097/01.coc.0000071382.14174.c5
Publikováno v:
Drug Information Journal. 29:893-902
During the last 25 years, there has been considerable interest in in vitro-in vivo relationships of oral dosage forms. The advantages are obvious in terms of cost, time, and safety. This paper considers the problems involved in establishing in vitro-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::987b589ebc916c0189903f6654d65c0c
https://doi.org/10.1177/009286159502900311
https://doi.org/10.1177/009286159502900311
Autor:
H Movahhed, S T Forgue, Rashmi H. Barbhaiya, Catherine A. Knupp, Carol Gleason, J Tenney, D J Weidler, Kenneth A. Pittman, R. Russell Martin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:552-557
The pharmacokinetics of cefepime in 31 young, healthy volunteers were assessed after the administration of single and multiple 250-, 500-, 1,000-, or 2,000-mg intravenous doses. Each subject received a single dose of cefepime via a 30-min intravenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26a7eec6ab57739d95129e395fec997
https://doi.org/10.1128/aac.36.3.552
https://doi.org/10.1128/aac.36.3.552
Autor:
B P, Smith, F R, Vandenhende, K A, DeSante, N A, Farid, P A, Welch, J T, Callaghan, S T, Forgue
Publikováno v:
Pharmaceutical research. 17(10)
The aim of this work was a pragmatic, statistically sound and clinically relevant approach to dose-proportionality analyses that is compatible with common study designs.Statistical estimation is used to derive a (1-alpha)% confidence interval (CI) fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43a061ed300187e70ad1e19586a88726
https://pubmed.ncbi.nlm.nih.gov/11145235
https://pubmed.ncbi.nlm.nih.gov/11145235
Publikováno v:
Biopharmaceuticsdrug disposition. 17(6)
To assess the delivery characteristics of a new 7 day 17 beta-estradiol transdermal delivery system (TDS), estradiol and estrone pharmacokinetics were evaluated following a single 7 d application of one TDS or two TDSs in 24 healthy, postmenopausal w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b04330aabab3b6f8cdd7004bfe52630
https://pubmed.ncbi.nlm.nih.gov/8866037
https://pubmed.ncbi.nlm.nih.gov/8866037
Autor:
R H, Barbhaiya, C A, Knupp, S T, Forgue, G R, Matzke, C E, Halstenson, J A, Opsahl, K A, Pittman
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(1)
The metabolism and disposition of an iv-administered, 1000 mg (100 microCi) single dose of the 14C-labeled cephalosporin cefepime was studied in healthy and renally impaired male volunteers. The 14C-label was located in the methyl group of the N-meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f01a357f3b5affb62ac3acec227db52
https://pubmed.ncbi.nlm.nih.gov/1673424
https://pubmed.ncbi.nlm.nih.gov/1673424
Autor:
S T Forgue, Kenneth A. Pittman, Rashmi H. Barbhaiya, D J Weidler, R. Russell Martin, Carol Gleason, Catherine A. Knupp
In this double-blind, single-dose phase I study, the safety and tolerance of cefepime were assessed in 24 healthy male subjects, with ceftazidime as the control drug. Four subjects in each of the six dose groups (62.5, 125, 250, 500, 1,000, or 2,000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6e12ad93eabe20ed42bd44ebfd706a
https://europepmc.org/articles/PMC171768/
https://europepmc.org/articles/PMC171768/
Publikováno v:
Antimicrobial Agents and Chemotherapy. 31:799-804
The disposition of the novel cephalosporin cefepime (BMY-28142) was characterized for intravenous administration of single doses to rats and cynomolgus monkeys, the species used most extensively for safety evaluation of the compound. Serial blood sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa053105c58c253aa0fbe236b1c0999
https://doi.org/10.1128/aac.31.5.799
https://doi.org/10.1128/aac.31.5.799
Publikováno v:
Journal of chromatography. 414(2)
High-performance liquid chromatographic methods for quantification of a novel carbapenem anti-infective agent, I, in plasma and urine have been developed, validated, and applied to clinical samples. The carbapenem is stabilized in the matrix by the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc0b760eb54069e11fe073f2890789d
https://pubmed.ncbi.nlm.nih.gov/3571402
https://pubmed.ncbi.nlm.nih.gov/3571402
Publikováno v:
Antimicrobial agents and chemotherapy. 31(1)
A high-pressure liquid chromatographic assay was developed for the quantitative analysis of a new cephalosporin, BMY-28142, in plasma and urine. The plasma method involved protein precipitation with acetonitrile and trichloroacetic acid followed by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32fee625051578d334aa1fd7028c1cd
https://pubmed.ncbi.nlm.nih.gov/3566239
https://pubmed.ncbi.nlm.nih.gov/3566239