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Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification

Autor: R A, Gjerset, S, Lebedeva, A, Haghighi, S T, Turla, D, Mercola

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(8)

We have previously shown, by expression of a nonphosphorylatable dominant inhibitor mutant of c-Jun [cJun(S63A,S73A)], that activation of the NH2-terminal Jun kinase/stress-activated protein kinase by genotoxic damage is required for DNA repair. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c86a186245cd842c1403c759198463d4
https://pubmed.ncbi.nlm.nih.gov/10470854

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