Zobrazeno 1 - 10
of 26
pro vyhledávání: '"S T, Kau"'
Autor:
J H, Li, G D, Yasay, S T, Kau, C J, Ohnmacht, D A, Trainor, A D, Bonev, T J, Heppner, M T, Nelson
Publikováno v:
Arzneimittel-Forschung. 46(5)
The potassium (K+) channel opening activity of ZM244085 (9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridined ione, CAS 149398-59-4), a novel dihydropyridine (DHP), was ascertained. In a set of functional assays, its mechanoinhibitory effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4eed64517e1a8186c2a6136696f6b14
https://pubmed.ncbi.nlm.nih.gov/8737640
https://pubmed.ncbi.nlm.nih.gov/8737640
Publikováno v:
Research communications in molecular pathology and pharmacology. 88(2)
Zeneca ZM244085, 9-(3 cyanophenyl)hexahydro-1,8 acridinedione, is a novel dihydropyridine (DHP) which relaxes KCl precontracted urinary bladder smooth muscle in vitro. The effect of ZM244085 on low and high KCl induced contractions, 86Rb efflux and [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54339b4ba69b672001881a5e5b3a478b
https://pubmed.ncbi.nlm.nih.gov/7670846
https://pubmed.ncbi.nlm.nih.gov/7670846
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 267(3)
The blockade of amphibian epithelial sodium channels by amiloride has been shown to not be a simple diffusion-limited encounter but rather a selective binding process with the rate of approach of the molecule for the channel site determined by the si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7dd146f8eb27ca23a567f1f7dc135e42
https://pubmed.ncbi.nlm.nih.gov/8263768
https://pubmed.ncbi.nlm.nih.gov/8263768
Autor:
P A, Johnston, S T, Kau
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 264(2)
The site of action of ICI 206,970, an aminomethylphenol pyrazine derivative, with effects on Na+ and water excretion similar to hydrochlorothazide, was determined using free-flow micropuncture and in vivo microperfusion techniques. Furosemide and ICI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aca11b61880cd8547b3e03d89d0185e3
https://pubmed.ncbi.nlm.nih.gov/8437111
https://pubmed.ncbi.nlm.nih.gov/8437111
Autor:
P A, Johnston, S T, Kau
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 14(7)
Increases in the delivery of solute to the loop of Henle result in increased reabsorption, vasoconstriction of the afferent arteriole, and a reduction in the glomerular filtration. Although the details of this tubuloglomerular feedback (TGF) mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c94de957cf8c7a0735caa8eb6c5b5377
https://pubmed.ncbi.nlm.nih.gov/1287376
https://pubmed.ncbi.nlm.nih.gov/1287376
Autor:
P A, Johnston, S T, Kau
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 260(2)
ICI 207,828 is a novel eukalemic diuretic in animals that is comparable in effect to hydrochlorothiazide. We used micropuncture and microperfusion techniques to determine the site(s) of action of this compound in the rat nephron. Either furosemide (F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85c836ed0987b4a5f9b8d4e8162c5433
https://pubmed.ncbi.nlm.nih.gov/1738095
https://pubmed.ncbi.nlm.nih.gov/1738095
Autor:
S T, Kau, B B, Howe, P A, Johnston, J H, Li, T J, Halterman, J S, Zuzack, K, Leszczynska, C L, Yochim, J A, Schwartz, R E, Giles
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 260(2)
ICI 207,828, an aminomethylphenol pyrazine derivative, produces water diuretic effects with only minimal alterations in kaliuresis in dogs and rats after oral and parenteral administration. In the dog, ICI 207,828 reached maximum activity at a dose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecc3784b5e3d210eb2f2e3fa8716e79f
https://pubmed.ncbi.nlm.nih.gov/1738094
https://pubmed.ncbi.nlm.nih.gov/1738094
Autor:
P A, Johnston, S T, Kau
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 256(2)
Free-flow micropuncture and in situ microperfusion techniques were used to define the site of action and relative effect of MK447 [2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol hydrochloride] vs. furosemide in the rat kidney. MK447 was administere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6af01e3a03150c37b299433919241fd9
https://pubmed.ncbi.nlm.nih.gov/1993996
https://pubmed.ncbi.nlm.nih.gov/1993996
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 12(10)
In this paper we report on a series of experiments evaluating a model of renal artery infusion (RAI) as a screening technique for comparison of new diuretics, and test some assumptions underlying its use. The femoral artery and vein of Beagle dogs we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c9c1b4306baf07bbd3ca6250a0ece01
https://pubmed.ncbi.nlm.nih.gov/2100755
https://pubmed.ncbi.nlm.nih.gov/2100755
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 12(7)
2-Aminoethyl-4-(1,1-dimethylethyl)-6-iodophenol hydrochloride (MK447) is a chemically novel diuretic that has oral efficacy and potency greater than furosemide (FUR). In this study, the relative efficacy and potency of MK447 and FUR were assessed fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::364e1dc9a3e395dc67ca50343c2932fd
https://pubmed.ncbi.nlm.nih.gov/2087148
https://pubmed.ncbi.nlm.nih.gov/2087148