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Akademický článek

Regulatory mutations in the human lipoprotein lipase gene in patients with familial combined hyperlipidemia and coronary artery disease

Autor: W S Yang, D N Nevin, L Iwasaki, R Peng, B G Brown, J D Brunzell, S S Deeb

Publikováno v: Journal of Lipid Research, Vol 37, Iss 12, Pp 2627-2637 (1996)

We previously reported a compound heterozygote [T(-39)C/T(-93)G] in the human lipoprotein lipase (LPL) gene promoter in one out of 19 patients with familial combined hyperlipidemia (FCHL) and reduced post-heparin plasma LPL levels. The T(-39)C substi

Externí odkaz: https://doaj.org/article/3ab92257c4e74fe5808d69ec4db956c6

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Akademický článek

Absence of N-glycosylation at asparagine 43 in human lipoprotein lipase induces its accumulation in the rough endoplasmic reticulum and alters this cellular compartment.

Autor: R Buscá, M A Pujana, P Pognonec, J Auwerx, S S Deeb, M Reina, S Vilaró

Publikováno v: Journal of Lipid Research, Vol 36, Iss 5, Pp 939-951 (1995)

Lipoprotein lipase (LPL) is the enzyme responsible for the hydrolysis of plasma triglycerides from apolipoprotein C-II-containing lipoproteins at the capillary endothelium and it is synthesized in parenchymal cells of several tissues. Intracellular L

Externí odkaz: https://doaj.org/article/a268b32902d042b5a86aa393e4b19dc0

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Epigenetic control of expression of the human L- and M- pigment genes

Autor: D. Bisset, S. S. Deeb, L. Fu

Publikováno v: Ophthalmic and Physiological Optics. 30:446-453

Epigenetics alters gene expression by chromatin modification without changing the sequence of DNA. DNA methylation is an essential signal for epigenetic gene regulation. Methylation of cytosine bases at CpG dinucleotides in DNA results in chromatin c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e15b75b005fe9f0c968cd7d2d44a945c
https://doi.org/10.1111/j.1475-1313.2010.00735.x

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A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men

Autor: L. M. Stone, S. E. Kahn, W. Y. Fujimoto, S. S. Deeb, D. Porte

Publikováno v: Diabetes. 45:422-428

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::372d583afbb8c88a3414ff92b8677943
https://doi.org/10.2337/diabetes.45.4.422

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Epigenetic control of expression of the human L- and M- pigment genes

Autor: S S, Deeb, D, Bisset, L, Fu

Publikováno v: Ophthalmicphysiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). 30(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ea13a68b095ab010d8a7b12ce1d5721
https://pubmed.ncbi.nlm.nih.gov/20883327

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The molecular basis of variation in human color vision

Autor: S S, Deeb

Publikováno v: Clinical genetics. 67(5)

Common variation in red-green color vision exists among both normal and color-deficient subjects. Differences at amino acids involved in tuning the spectra of the red and green cone pigments account for the majority of this variation. One source of v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13ebc5cbce8b253dbd1fb36549c574f9
https://pubmed.ncbi.nlm.nih.gov/15811001

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Genotypic Variation in Multi-Gene Dichromats

Autor: S. S. Deeb, Wolfgang Jagla, T. Hayashi, L. T. Sharpe, H. Jägle

Publikováno v: Normal and Defective Colour Vision

The gene arrays of multi-gene dichromats are quite heterogeneous with respect to both the type of hybrid gene and the total number of genes. Hybrid genes play a major role in causing dichromacy. This chapter shows that dichromacy results if the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1647337e19b8baf8b941e18c023f3bca
https://doi.org/10.1093/acprof:oso/9780198525301.003.0031

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Derivation of Beam Interpolation Coefficients with Application to the K-omega Beamformer

Autor: Robert A LaTourette, S S Deeb

A problem of general interest is to be able to use a set of L beams, steered and focused respectively at the bearing-range pairs Theta1, R1, Theta2, R2,..., Theta(sub L), R(sub L), to approximate a beam steered and focused at a given angle-range pair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb80d70cdace91f2920bf51003c571b2
https://doi.org/10.21236/ada390410

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The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity

Autor: M C, Carr, J E, Hokanson, A, Zambon, S S, Deeb, P H, Barrett, J Q, Purnell, J D, Brunzell

Publikováno v: The Journal of clinical endocrinology and metabolism. 86(6)

Hepatic lipase (HL) hydrolyzes triglyceride and phospholipid in low and high density lipoprotein cholesterol (LDL-C and HDL-C, respectively), and elevated HL activity is associated with small, dense atherogenic LDL particles and reduced HDL2-C. Eleva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::621ebc831bdf2a38e1787e170fba7a0e
https://pubmed.ncbi.nlm.nih.gov/11397895

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In vivo evidence of a role for hepatic lipase in human apoB-containing lipoprotein metabolism, independent of its lipolytic activity

Autor: A, Zambon, S S, Deeb, A, Bensadoun, K E, Foster, J D, Brunzell

Publikováno v: Journal of lipid research. 41(12)

Hepatic lipase (HL) is a key player in lipoprotein metabolism by modulating, through its lipolytic activity, the triglyceride (TG) and phospholipid content of apolipoprotein B (apoB)-containing lipoproteins and of high density lipoproteins (HDL), the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5a580699d9d73778cd9cdc04c830a4c
https://pubmed.ncbi.nlm.nih.gov/11108744

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