Zobrazeno 1 - 10 of 157 pro vyhledávání: '"S S, Tucker"'
1
Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists
Autor: L. M. Vickery, R. M. Muccitelli, M A Wasserman, S. S. Tucker, Erhard Kf, J. F. Devan, Irene N. Uzinskas, John G. Gleason, M. E. Mccarthy, Carl D. Perchonock
Publikováno v: Journal of Medicinal Chemistry. 29:1442-1452
A series of 5-alkynyl- and 5-aryl-4,6-dithianonanedioic acids and related compounds has been prepared for evaluation of leukotriene antagonist activity. The alkynyl compounds were prepared by thioacetal exchange from the corresponding acetylenic acet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dead8941f770109bad4a3c67c37279a
https://doi.org/10.1021/jm00158a021
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2
Inhibition of the low km cyclic AMP phosphodiesterase in intact canine trachealis by SKF 94836: mechanical and biochemical responses
Autor: T J, Torphy, M, Burman, L B, Huang, S S, Tucker
Publikováno v: The Journal of pharmacology and experimental therapeutics. 246(3)
The mechanical and biochemical responses of the canine trachealis to SKF 94836 [2-cyano-1-methyl-3-[4-(4-methyl-6-oxo- 1,4,5,6-tetrahydropyridazine-3-yl)phenyl]guanidine], a selective inhibitor (ki = 1-3 microM) of the low km cyclic AMP (cAMP) phosph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28f5fe73e46fe412761b9868df8bc873
https://pubmed.ncbi.nlm.nih.gov/2843631
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4
Effects of SKF 93944 (Temelastine), a potent histamine H1-receptor antagonist in pharmacologic and antigen-induced bronchoconstriction
Autor: P E, Malo, R, Muccitelli, S S, Tucker, M A, Wasserman
Publikováno v: Methods and findings in experimental and clinical pharmacology. 8(8)
SKF 93944, a previously reported non-sedating histamine H1-receptor antagonist, was evaluated for its ability to block pharmacologic-and antigen-induced bronchoconstriction. In the isolated guinea pig trachea, SKF 93944 (10(-9)-10(-7) M) produced a c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6bf3aa4f1178a81b706f40df88dd57f
https://pubmed.ncbi.nlm.nih.gov/2875234
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7
Effect of calcium antagonists on leukotriene D4-induced contractions of the guinea-pig trachea and lung parenchyma
Autor: B M, Weichman, R M, Muccitelli, S S, Tucker, M A, Wasserman
Publikováno v: The Journal of pharmacology and experimental therapeutics. 225(2)
The directly mediated contractile activity of leukotriene (LT) D4 on isolated guinea-pig trachea and lung parenchyma was dependent upon the presence of calcium in the bathing buffer. Whereas 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate (TMB-8)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3da87f2ae444a1fbe0c608cc77dd3439
https://pubmed.ncbi.nlm.nih.gov/6842394
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9
Effect of calcium antagonists on the biosynthesis and contractile effects of peptidoleukotrienes in rhesus monkey lung
Autor: B M, Weichman, R M, Muccitelli, S S, Tucker, J F, DeVan
Publikováno v: The Journal of pharmacology and experimental therapeutics. 233(2)
Anti-human Ig (immunoglobulin) E induced the release of 2.84 +/- 0.33 ng/ml of immunoreactive leukotrienes (iLTs) from passively sensitized, fragmented rhesus monkey lung, whereas tissue not challenged with anti-IgE released 0.21 +/- 0.08 ng/ml of iL
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84f7331ae5434cb7e82a1165ebbb183c
https://pubmed.ncbi.nlm.nih.gov/3999025
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