Zobrazeno 1 - 10 of 72 pro vyhledávání: '"S S, Trofimov"'
1
The impact of a binary catalyst system «tereftal + ascorbic acid» on the central nervous system
Autor: L. M. Michailova, V. M. Bukhman, N. Y. Kulbachevskaya, O. I. Konyaeva, N. P. Ermakova, S. S. Trofimov
Publikováno v: Russian Journal of Biotherapy. 16:42-49
Introduction. Neurotoxicity is one of the specific systemic complications of anticancer chemotherapy. Detection in experimental animals complications of psychotropic or neurotropic action of the new drug is one of the most difficult challenges of pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f2974c28a4850b1c8894eb996a76629
https://doi.org/10.17650/1726-9784-2017-16-2-42-49
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2
Synthesis and pharmacological activity of analogs of the endogenous neuropeptide cycloprolylglycine
Autor: S. S. Trofimov, K. N. Kolyasnikova, M. A. Konstantinopol’skii, M. V. Vichuzhanin, T. A. Gudasheva
Publikováno v: Pharmaceutical Chemistry Journal. 46:96-102
A series of analogs and homologs of the endogenous cyclic dipeptide cycloprolylglycine were synthesized. The nootropic properties of the synthesized compounds were investigated on an experimental model of a passive avoidance test with electroshock- o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4c6f494fcc39b43638e6c13c8569d7f
https://doi.org/10.1007/s11094-012-0741-0
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3
Designing nootropic dipeptides using an evolutionary-genetic approach
Autor: S. V. Nikitin, Sergey B. Seredenin, T. A. Gudasheva, S. S. Trofimov, R. U. Ostrovskaya, A. A. Morozova, T. A. Voronina
Publikováno v: Pharmaceutical Chemistry Journal. 40:18-22
A novel approach to the search for the new groups of biologically active peptides is developed, which is based on the selection of point mutants with respect to noncritical amino acid residues. Using a gene site encoding the arginine vasopressin AVP(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fc6cd4b3319388aa725190134f08fbf
https://doi.org/10.1007/s11094-006-0049-z
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4
The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-l-prolylglycine
Autor: R. U. Ostrovskaya, T. A. Voronina, S. S. Boyko, S. S. Trofimov, G. G. Rozantsev, T. A. Gudasheva, A. P. Skoldinov, V. K. Akparov, Sergey B. Seredenin, V. P. Zherdev
Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 22:245-252
The metabolism of a new piracetam analogue, the dipeptide cognitive enhancer N-phenylacetyl-L-prolylglycine ethyl ester (GVS-111) was studied in vivo. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of dete
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a90f89fa56f2f716274b9eec63dad6
https://doi.org/10.1007/bf03189814
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6
Synthesis and antiamnesic activity of a series of N-acylprolyl-containing dipeptides
Autor: R. U. Ostrovskaya, T. A. Gudasheva, A. P. Skoldinov, Sergey B. Seredenin, S. S. Trofimov, Natalya I. Vasilevich, E. V. Kravchenko, G. G. Rozantsev, T. A. Voronina
Publikováno v: European Journal of Medicinal Chemistry. 31:151-157
Summary Esters and amides of a series of N -acylprolyl-containing dipeptides were synthesized. It was established that these substances possess the ability to prevent memory decline evoked by maximal electroshock (MES) in a passive avoidance step-thr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::917b5a26b3c6a450e547085c3a91c94d
https://doi.org/10.1016/0223-5234(96)80448-x
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7
Synthesis of pyroglutamylasparagine amide dipeptide fragment of vasopressin, and the stereoselectivity of its Mnemic effect
Autor: R. U. Ostrovskaya, Sergey B. Seredenin, G. G. Rozantsev, T. A. Voronina, T. A. Gudasheva, S. S. Trofimov, A. P. Sklodinov
Publikováno v: Pharmaceutical Chemistry Journal. 29:14-17
Four diastereomers of pGlu-Asn-NH2 were synthesized. They were considered on one hand as a peptide analogue of piracetam, and on the other as an N-terminal fragment of the major metabolite of vasopressin [pGlu4, -Cyt6] AVP(4–9). The influence of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::542af9fc4407e1addd980c64b4fa5c7d
https://doi.org/10.1007/bf02219454
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8
Effects of afobazole on cognitive behavior of the offspring of rats exposed to tobacco smoke during gestation period
Autor: I. B. Tsorin, S. B. Seredenin, O. V. Shreder, S. S. Trofimov, A. S. Solomina, Andrey D. Durnev
Publikováno v: Bulletin of experimental biology and medicine. 151(1)
Experiments on the model of foraging behavior formation under conditions of free choice (T-maze) revealed learning failure against the background of reduced motor activity in the offspring of rats exposed to tobacco smoke on gestation days 1–20. Af
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5de0b4c5dc273ec0ba21ac5884ae3bc
https://pubmed.ncbi.nlm.nih.gov/22442799
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